1990
DOI: 10.1227/00006123-199003000-00004
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Pituitary Adenomas that Produce Adrenocorticotropic Hormone and A-Subunit: Clinicopathological, Immunohistochemical, Ultrastructural, and Immunoelectron Microscopic Studies in Nine Cases

Abstract: Eight surgical and one autopsy specimen of pituitary adenomas (six cases of Cushing's disease, two of Nelson's syndrome. and one of hypopituitarism) were studied by histochemical, immunohistocytological, and ultrastructural methods. Eight tumors showed the characteristic histochemical profile of corticotroph adenoma—amphophilic to basophilic, and periodic acid-Schiff-positive to some extent. In all tumors, immunohistochemical studies revealed adrenocorticotropic hormone (ACTH) and à-subunit in the cytoplasm of… Show more

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Cited by 26 publications
(22 citation statements)
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“…Immunostaining reveals strong reactions for ACTH. Other peptides derived from proopiomelanocortin may also be found, and in some cases, a-subunit or galanin (59,60). Electron microscopy shows monomorphic spherical or ovoid nuclei with distinct nucleoli, a moderately developed rough endoplasmic reticulum, spherical medium-sized Golgi fields and numerous slightly pleomorphic secretory granules with diameters between 200 and 450 nm.…”
Section: Acth-secreting Adenomas In Cushing's Disease or Nelson's Synmentioning
confidence: 98%
“…Immunostaining reveals strong reactions for ACTH. Other peptides derived from proopiomelanocortin may also be found, and in some cases, a-subunit or galanin (59,60). Electron microscopy shows monomorphic spherical or ovoid nuclei with distinct nucleoli, a moderately developed rough endoplasmic reticulum, spherical medium-sized Golgi fields and numerous slightly pleomorphic secretory granules with diameters between 200 and 450 nm.…”
Section: Acth-secreting Adenomas In Cushing's Disease or Nelson's Synmentioning
confidence: 98%
“…Coexpression of ACTH and related peptides and PRL (Fig. 3) (Sherry et al, 1982), ACTH and TSH (Lindboe et al, 1993), and ACTH and ␣-subunit (Berg et al, 1990) have Immunostaining for prolactin (a) was negative. However, in situ hybridization for prolactin mRNA (b) gave a positive signal, indicating that the tumour was the most likely source of the increased circulating prolactin.…”
Section: Pituitary Adenomas Classical Pituitary Hormonesmentioning
confidence: 99%
“…Hormonality of secretory granules is believed to be determined at the time of differentiation from progenitor cells to hormone secreting cells through stem cells [10-14, 17, 18, 26, 29, 31-33, 35]. Recent immunological and gene technology enables us to detect multihormonality of different cell lines in the same secretory granules [5,15,21,29]. The stem cell theory has difficulty in explaining the multihormonal character.…”
Section: Introductionmentioning
confidence: 99%