Pituitary adenylate cyclase activating peptide mediates inhibitory nonadrenergic noncholinergic relaxation

Yoshida, Makoto; Aizawa, Hisamichi; Takahashi, Naotsugu; Shigyo, Mutsumi; Hara, Nobuyuki

doi:10.1016/s0014-2999(00)00167-9

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…Feeding state has a great effect on gastrointestinal tract motility [6]. Along with glucagon-like peptide-1 (GLP-1), PACAP is present in the avian intestine [9,36] and takes part in the regulation of intestinal motility as a smooth muscle relaxant [30,45]. This PACAP function has been confirmed as gastric motility is reduced when PACAP is injected peripherally [33].…”

Section: Discussionmentioning

confidence: 99%

Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens

Simon

Oláh

Komlósi

et al. 2017

Acta Biologica Hungarica

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The list of orexigenic and anorexigenic peptides, those are known to alter feed intake, is continuously growing. However, most of them are studied in mammalian species. We aimed to investigate plasma level and mRNA expression of the pituitary adenylate cyclase-activating polypeptide (PACAP), gene expression of its receptor (PAC1), furthermore the gene expression of galanin (GAL), neuromedin U (NMU), and its two receptors (NMUR1 and NMUR2) in the hypothalamus, proventriculus, and jejunum of hens exposed to 40% calorie restriction. Feed restriction resulted in a 88% increase in mRNA and a 27% increase in peptide level of PACAP in proventriculus measured with qPCR and RIA, respectively. Increases were found in the gene expression of PAC1 (49%) and NMUR1 (63%) in the hypothalamus. Higher expressions of peptide encoding genes (76% for PACAP, 41% for NMU, 301% for NMUR1 and 308% for GAL, P < 0.05) were recorded in the jejunum of hens exposed to restricted nutrition. The results indicate that PACAP level responds to calorie restriction in the proventriculus and jejunum, but not in the hypothalamus and plasma.

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Section: Discussionmentioning

confidence: 99%

Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens

Simon

Oláh

Komlósi

et al. 2017

Acta Biologica Hungarica

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“…These neurons may serve as inhibitory motor neurons in the regulation of ureteral motility. This is supported by the finding that PACAP is a potent relaxant of vascular and non-vascular smooth muscle (Katsolius et al 1993;McConalogue et al 1995;Naruse et al 1996;Ozawa et al 1997;Yoshida et al 2000) and, hence, it may play a complementary role to VIP and NO in mediating inhibitory non-adrenergic noncholinergic neurotransmission in the avian ureter.…”

Section: Discussionmentioning

confidence: 85%

Pituitary adenylate cyclase activating peptide (PACAP) immunoreactivity in the ureter of the duck

Mirabella

Squillacioti

Germanò

et al. 2001

Cell and Tissue Research

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The presence, distribution and colocalisation of pituitary adenylate cyclase activating peptide (PACAP) immunoreactivity have been studied in the duck ureter by using Western blot analysis, radioimmunoassays (RIA) and immunohistochemistry. The presence of both PACAP-38 and PACAP-27 was demonstrated, PACAP-38 being the predominant form. PACAP-immunoreactive fibres and neurons were found in all the ureteral layers. Double immunostaining showed that PACAP was almost completely colocalised with vasoactive intestinal peptide (VIP). Moreover, PACAP was found in substance P (SP)-containing ureteral nerve fibres and in SP-containing dorsal root ganglion neurons. RIA performed on denervated ureters demonstrated that almost half of the ureteral PACAP was extrinsic in origin. These findings suggest that, in birds, PACAP has a role in diverse nerve-mediated ureteral functions.

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“…This is supported by the fact that PAC1 receptor mRNA is expressed in the avian gut (Peeters et al, 1999). Moreover, many functional studies indicate that PACAP has a potent relaxant activity on gastrointestinal smooth muscle (Katsolius et al, 1993;McConalogue et al, 1995;Yoshida et al, 2000) and important secretomotor properties throughout the gastrointestinal tract (Cox 1992;Kuwahara et al, 1993;Fuchs et al, 1996;Ozawa et al, 1997;Takeuchi et al, 1997).…”

Section: Discussionmentioning

confidence: 98%

Immunohistochemical Study on Glucagon-Like Peptide-1(GLP-1) and Pituitary Adenylate Cyclase Activating Peptide (PACAP) in the Small Intestine of <i>Muscovy </i>Duck during the Prehatching and Posthatching Periods

Ding¹,

Lenzi

Pirone

2014

J. Poult. Sci.

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The distributions and frequencies of some endocrine cells in the small intestine of Muscovy duck during development were studied with immunohistochemical method using two types of antisera against Glucagon-like peptide-1 (GLP-1) and Pituitary adenylate cyclase activating peptide (PACAP). In the small intestine, GLP-1 was first observed in the jejunum at E24 and in the duodenum at E30. However PACAP labeled fibers were first noted in the jejunum and the ileum at E30. The density of GLP-1immunoreactive cells reached the peak at hatch in the duodenum, while in the jejunum and ileum got the peak at 2d (P＜0.05). The density of PACAP positive cells reached the peak in the jejunum and ileum at hatch and in the proximal duodenum at 2d and in the distal duodenum at 9d (P＜0.05). The distribution of different endocrine cell type in the small intestine exhibit some particularities in the Muscovy duckling.These results can represent an useful information for future physiological investigations that will explore the exact role of PACAP and GLP-1 in the avian intestine during a critical period like the prehatch and posthatch.

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Pituitary adenylate cyclase activating peptide mediates inhibitory nonadrenergic noncholinergic relaxation

Cited by 8 publications

References 25 publications

Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens

Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens

Pituitary adenylate cyclase activating peptide (PACAP) immunoreactivity in the ureter of the duck

Immunohistochemical Study on Glucagon-Like Peptide-1(GLP-1) and Pituitary Adenylate Cyclase Activating Peptide (PACAP) in the Small Intestine of <i>Muscovy </i>Duck during the Prehatching and Posthatching Periods

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