Pituitary-adrenal correlates of schedule-induced polydipsia and wheel running in rats

Tazi, A.; Dantzer, Robert; Mormède, Pierre; Moal, Michel Le

doi:10.1016/0166-4328(86)90025-2

Cited by 55 publications

(38 citation statements)

References 16 publications

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“…This finding confirms previous reports (Cardona et al 2006;Dantzer et al 1988a;Mittleman et al 1988a, b;Mittleman and Valenstein 1985;Tazi et al 1986) and extends individual differences in SIP drinking to other behaviors occurring during SIP sessions, such as licking and nose pokes. Specifically, HD rats developed SIP (ml and licking) faster and reached higher asymptotic levels than LD subjects, which displayed greater levels of nose pokes.…”

Section: Individual Differences In Schedule-induced Polydipsia Lickssupporting

confidence: 92%

“…Mittleman et al (1988a) observed a facilitatory effect on SIP drinking after repeated low doses (1 mg/kg) of diazepam during the acquisition of SIP, only in animals with high levels of SIP. Likewise, compared to non-polydipsic rats, polydipsic rats display gradual reductions in corticosterone (CORT) levels and increases in prolactin levels when water is available (Dantzer et al 1988a;Mittleman et al 1988b;Tazi et al 1986;Tazi et al 1988). In an elegant study about individual differences in SIP, Mittleman et al (1992) showed that the effects of CORT administration on established SIP depended not only on the dose of CORT administered but also on the amount of SIP drinking.…”

Section: Introductionmentioning

confidence: 99%

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Individual differences in schedule-induced polydipsia and the role of gabaergic and dopaminergic systems

et al. 2008

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These data provide novel evidence that individual differences in SIP are not predictive of behavioral reactivity in animal models of anxiety and suggest an important role for the dopaminergic system in such individual differences. These findings point to SIP as a useful animal model for investigating the neurobiological basis of vulnerability to several psychopathologies in which the dopaminergic system is involved.

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Section: Individual Differences In Schedule-induced Polydipsia Lickssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Individual differences in schedule-induced polydipsia and the role of gabaergic and dopaminergic systems

et al. 2008

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“…The suppression of HPA activity, indicated by a reduction in corticosterone levels, is conditioned to the response of drinking in the operant chamber and not in the home cage (Brett and Levine 1979). Furthermore, the decrease in corticosterone levels is conditioned to the presence of the bottle of water in the operant chamber; corticosterone levels are increased in polydipsic animals when the water bottle was removed from the experimental situation (Tazi et al 1986). The animals that engaged in excessive drinking in SIP displayed decreased plasma levels of corticosterone and increased levels of prolactin during the course of a SIP session compared with animals not developing this adjunctive behavior (Dantzer et al 1988a,b;Levine and Levine 1989).…”

Section: Neurobehavioral Basis Of Compulsivity In Sipmentioning

confidence: 99%

Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases

Moreno

Flores

2011

Psychopharmacology

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“…For example, the gastric ulceration developed by rats when forcibly restrained is significantly lower in animals that perform the apparently irrelevant displacement activity of biting an object (Vincent et al 1984). Adjunctive behaviour such as polydipsia (Brett & Levine 1979;Tazi et al 1986;Dantzer et al 1987) and chain-chewing by sows (Dantzer & Morm6de 1981) may also be accompanied by physiological signs of coping.…”

Section: Evidencementioning

confidence: 99%

Stereotypies: a critical review

1991

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Abstract. Stereotypies are repetitive, invariant behaviour patterns with no obvious goal or function. They seem to be restricted to captive animals, mentally ill or handicapped humans, and subjects given stimulant drugs. In this respect they are abnormal, although possibly the product of normal behavioural processes. Stereotypies are often associated with past or present sub-optimal aspects of the environment, and have been used as a welfare indicator. It has been hypothesized that stereotypies have beneficial consequences which reinforce their performance, although other means, such as positive feedback, may equally explain their persistence. Empirical evidence links them with lowered awareness of external events, and reduced arousal and distress. However, as most of this evidence is correlational it remains uncertain that the stereotypies are themselves the cause of coping. Furthermore, they are heterogeneous in source of origin, proximate causation and physical characteristics, and they change over time in important respects, becoming more readily elicited by a wider range of circumstances. Therefore the properties of one stereotypy are not necessarily those of another.

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Pituitary-adrenal correlates of schedule-induced polydipsia and wheel running in rats

Cited by 55 publications

References 16 publications

Individual differences in schedule-induced polydipsia and the role of gabaergic and dopaminergic systems

Individual differences in schedule-induced polydipsia and the role of gabaergic and dopaminergic systems

Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases

Stereotypies: a critical review

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