“…Numerous workers have attempted to explain the beneficial effects of ICT and E C T through activity of the hypothalamic-anterior pitui-tary-adrenal cortex axis, some of these concepts regarding I C T and ECT as non-specific stressors within the framework of the General Adaptation Syndrome (GAS) of Selye (45,47,98,104,149,308,425,445, ++6). 'The elevation of plasma 17-hydroxycorticosteroid level when the peripheral seizure is blocked by dilantiii and SKFz599 indicates direct central stimulation as the source (48); since the anterior pituitary does not respond directly to electrical stimulation, the hypothalamo-anterior pituitary system is implicated, with release of ACTH.…”