Pituitary dysfunction due to sports-related traumatic brain injury

Hacıoğlu, Ayşa; Keleştimur, Fahrettin; Tanrıverdi, Fatih

doi:10.1007/s11102-019-00937-z

Cited by 27 publications

(8 citation statements)

References 74 publications

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“…Turkey was the only country that reported on neuroendocrine issues related to concussion injuries. The research in this area was abundant, especially pointing to mTBI in chronic head trauma in boxing, with altered pituitary function, low levels of growth hormones and a small size pituitary (Temizkan et al, 2019;Hacioglu et al, 2019). On the other hand, Iranian researchers were interested in post-traumatic headache in athletes (Jahani et al, 2016) concluding that its incidence was low unless the sport was wrestling, and that post-traumatic headache was an indicator for post-concussion recovery.…”

Section: Resultsmentioning

confidence: 99%

A Perspective From the Middle East on the Topic of Concussion

Chemali¹,

Ezzeddine²,

Tcheroyan³

et al. 2020

GJHS

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Background: Concussion is the most prevalent form of traumatic brain injury. Western countries debate it as a public health issue. Middle Eastern (ME) countries lag behind with a concussion incidence surveillance of 25% that of European countries. Objective: The purpose of our study was to review concussion resulting from traumatic brain or sports injuries in civilian nationals of the ME. Methods: We carried out PubMed literature search of all related articles in the past thirty years using search terms reflecting concussion and sports injuries in ME countries of Bahrain, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Palestine, Qatar, Saudi Arabia, Syria, Turkey, United Arab Emirates, and Yemen. Results: 72 articles met our search criteria with relatively little data found on concussion within the parameters of this review. However, the reports that were found were diverse. Israel, Turkey and Iran led in publications. Motor vehicle accidents were the leading cause of concussion from TBI (50-57%) followed by domestic injuries (30-40%) and sports injuries at 4-7%. Extremity injuries were most commonly reported unlike head injuries often invisible and underreported. Male gender, young children, pedestrian and car traffic accidents, lack of protective gear, cell phone use, impulsive behaviors as well as training overload, lack of sleep, contact sports and violence were all risk factors for concussion. Conclusions: In this review, we highlighted the nascent topic of concussion in the ME and the need for additional research dictating awareness programs and implementing new safety policies to lower morbidity and mortality across all ages.

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Section: Resultsmentioning

confidence: 99%

A Perspective From the Middle East on the Topic of Concussion

Chemali¹,

Ezzeddine²,

Tcheroyan³

et al. 2020

GJHS

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“… 32 , 33 In the context of SRC, potential HPA-axis dysfunction could lead to decreased GC secretion, unchecked neuroinflammation, and an impaired stress response. 9 , 34 , 35 Additionally, animal TBI studies have shown how associated peripheral injuries may influence inflammation and recovery after brain injury, which may be relevant in clinical SRC studies. 36 , 37 …”

Section: Discussionmentioning

confidence: 99%

Hiding in Plain Sight: Factors Influencing the Neuroinflammatory Response to Sport-Related Concussion

Tabor

McCrea

Meier

et al. 2022

Neurotrauma Reports

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Sport-related concussion (SRC) is a major concern among athletes and clinicians around the world. Research into fluid biomarkers of SRC has made significant progress in understanding the complex underlying pathophysiology of concussion. However, little headway has been made toward clinically validating any biomarkers to improve the clinical management of SRC. A major obstacle toward clinical translation of any fluid biomarker is the heterogeneity of SRC overlapping with multiple physiological systems involved in pathology and recovery. Neuroinflammation post-SRC is one such system that may confound fluid biomarker data on many fronts. Neuroinflammatory processes consist of cell mediators, both within the central nervous system and the periphery, that play vital roles in regulating the response to brain injury. Further, neuroinflammation is influenced by many biopsychosocial variables present in most athletic populations. In this commentary, we propose that future fluid biomarker research should take a systems biology approach in the context of the neuroinflammatory response to SRC. We highlight how biological variables, such as age, sex, immune challenges, and hypothalamic-pituitary-adrenal (HPA)-axis responses to stress, may alter neuroinflammation. Further, we underscore the importance of accounting for health and lifestyle variables, such as diet, exercise, sleep, and pre-morbid medical factors, when measuring inflammatory markers of SRC. To successfully move toward clinical translation, fluid biomarker research should take a more holistic approach in study design and data interpretation, collecting information on hidden variables that may be influencing the neuroinflammatory response to SRC.

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“…Brazilian investigators have studied the association between low LH and testosterone levels with morbidity and mortality during the acute phase of severe TBI, but the role of these hormones as prognostic factors is still uncertain (19). Similarly, sports-related TBI, comprising continuous or acute trauma in professional athletes, amateur sporting, or even during recreational activities, may also result in pituitary dysfunction that is commonly neglected and undiagnosed (20).…”

Section: Etiologymentioning

confidence: 99%

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism

Garmes

Boguszewski

Miranda

et al. 2021

Archives of Endocrinology and Metabolism

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Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.

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Pituitary dysfunction due to sports-related traumatic brain injury

Cited by 27 publications

References 74 publications

A Perspective From the Middle East on the Topic of Concussion

A Perspective From the Middle East on the Topic of Concussion

Hiding in Plain Sight: Factors Influencing the Neuroinflammatory Response to Sport-Related Concussion

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism

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