Pituitary Enlargement, Hypertrichosis and Blunted Growth Hormone Secretion in Primary Hypothyroidism

Nishi, Yoshikazu; Hamamoto, Kazuko; Kajiyama, Mizuto; Fujita, Atsushi; Kawamura, Isao; Kagawa, Yoshiteru; Kajima, Toshio; Yamanaka, Masami; Uozumi, Tohru

doi:10.1111/j.1651-2227.1989.tb10904.x

Cited by 16 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Severe primary hypothyroidism in children is associated with attenuated spontaneous GH secretion (Buchanan et al 1988, Chernausek & Turner 1989, Nishi et al 1989. In line with these observations are the findings of in vitro studies in cell lines derived from human GH-secreting pituitary tumours, which revealed that thyroid hormones promote GH mRNA accumulation (Chomczynski et al 1993) and GH release (Lamberts et al 1984).…”

Section: Introductionsupporting

confidence: 72%

Primary hypothyroidism in dogs is associated with elevated GH release

Diaz-Espineira²,

Mol³

et al. 2001

Journal of Endocrinology

View full text Add to dashboard Cite

The pulsatile secretion patterns of GH were investigated in seven beagle bitches by collecting blood samples every 10 min for 6 h during euthyroidism and 1·5 years after induction of primary hypothyroidism. Hypothyroidism was induced by surgical removal of the thyroid gland and subsequent destruction of any remnant thyroid tissue by oral administration of sodium [131 I]iodide. Some of the physical changes observed in the dogs with primary hypothyroidism mimicked those of acromegaly. During both euthyroidism and hypothyroidism GH was secreted in a pulsatile fashion. The mean ( ...) basal plasma GH concentration was significantly higher (P=0·003) in the hypothyroid state (4·1 1·6 µg/l) than in the euthyroid state (1·2 0·4 µg/l). Likewise, the mean area under the curve (AUC) for GH above the zero-level during hypothyroidism (27·0 10·0 µg/l 6 h) was significantly higher (P=0·004) than that during euthyroidism (11·7 2·0 µg/l 6 h). The mean AUC for GH above the baseline was significantly lower (P=0·008) during hypothyroidism (2·4 0·8 µg/l 6 h) than during euthyroidism (4·5 1·8 µg/l 6 h), whereas there was no significant difference in GH pulse frequency. The mean plasma IGF-I level was significantly higher (P<0·01) in the hypothyroid state (169 45 µg/l) than in the euthyroid (97 15 µg/l). The results of this study demonstrate that primary hypothyroidism in dogs is associated with elevated basal GH secretion and less GH secreted in pulses. This elevated GH secretion has endocrine significance as illustrated by elevated plasma IGF-I levels and some physical changes mimicking acromegaly. It is discussed that the increased GH release in hypothyroid dogs may be the result of the absence of a response element for thyroid hormone within the canine pituitary GH gene and alterations in supra-pituitary regulation.

show abstract

Section: Introductionsupporting

confidence: 72%

Primary hypothyroidism in dogs is associated with elevated GH release

Diaz-Espineira²,

Mol³

et al. 2001

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Although, hypothyroidism is usually associated with loss of hair, our case showed dark and thick hair on his back which also reported in other cases with untreated primary hypothyroidism [19]. The fact that the hypertrichosis resolved after thyroxine replacement therapy establishes the causal relationship between hypertrichosis and hypothyroidism.…”

Section: Discussionsupporting

confidence: 80%

Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report

Omran

Peng

Shrestha

et al. 2012

Case Reports in Pediatrics

View full text Add to dashboard Cite

Primary hypothyroidism in the juvenile population generally leads to retardation of linear growth and delay or even arrest of puberty. However, in rare conditions, children with long-standing hypothyroidism present with signs of Van Wyk-Grumbach's syndrome (VWGS) which include juvenile hypothyroidism, delayed bone age, and pseudoprecocious puberty. We report a rare case of prepubertal male child from Asian origin, presented with long-standing untreated hypothyroidism complicated with VWGS and other complications including obesity, short stature, hepatomegaly, asymptomatic mild pericardial effusion, and pituitary hyperplasia.

show abstract

“…Very few cases of hypertrichosis associated with congenital hypothyroidism have been described. [3–5] The causal association between hypothyroidism and hypertrichosis has not been reported in neonatal period, although congenitally hypothyroid infants often have a low hairline. Perloff reported four cases of hirsutism in children, who responded to thyroxine replacement therapy.…”

mentioning

confidence: 99%

“…reported three children with untreated primary hypothyroidism resulting in pituitary hyperplasia and hypertrichosis. [5] These abnormalities disappeared after thyroid hormone therapy. In our patient, stimulation of the growth of hair via adrenal androgens by TSH may be the probable pathophysiological mechanism.…”

mentioning

confidence: 99%