Pituitary Ependymoma: A Case Report and Review of the Literature

Wang, Sheng; Zong, Weifeng; Li, Youwei; Wang, Baofeng; Ke, Changsu; Guo, Dongsheng

doi:10.1016/j.wneu.2017.10.134

Cited by 14 publications

(19 citation statements)

References 28 publications

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“…From an anatomical perspective, in a 10-week (45-mm) human fetus, neurohypophysis develops as an elongated out-pouching of neuroepithelial cells, which encloses a cavity that is continuous with the cavity of the neural tube. At this stage, the infundibulum consists of undifferentiated ependymal cell precursors ( 3 ). Particularly, the ependymal cleft, which is not present at birth, is readily identified at 13-weeks during development (60-mm), although it recedes by 16-weeks (112-mm).…”

Section: Discussionmentioning

confidence: 99%

“…It is plausible that isolated ependymal cells or embryonic ependymoma remnants are left behind in the infundibulum and neurohypophysis. These cells might undergo subsequent neoplastic transformation ( 7 , 8 , 13 ), giving rise to an ependymoma ( 3 , 5 – 7 , 10 ). Other hypothesis speculates that SE might be a variant of pituicytoma ( 10 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

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Case Report: Sellar Ependymomas: A Clinic-Pathological Study and Literature Review

et al. 2021

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Ependymomas are primary glial tumors arising from cells related to the ependymal lining of the ventricular system. They are classified into at least nine different molecular subtypes according to molecular phenotype, histological morphology, and tumor location. Primary sellar ependymoma is an extremely rare malignancy of the central nervous system, with only 12 known cases reported in humans. We herein report a case of ependymoma located at the pituitary region in a 44-year-old female patient and discuss the molecular subtype, natural history, clinical presentation, radiological findings, histological features, immunohistochemical characteristics, ultrastructural examinations, treatment, and prognosis of sellar ependymoma. This case report may serve as a helpful reference for clinicians and radiologists in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Case Report: Sellar Ependymomas: A Clinic-Pathological Study and Literature Review

et al. 2021

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“…TTF-1 is considered to be an excellent marker of (both fetal and adult) pituicytes, the specialized glial cells of the neurohypophysis [39], although the matter of a common histogenesis for the entire group of TTF-1 immunopositive sellar/parasellar tumors (i.e., pituicytomas, granular cell tumors of the sellar region, spindle cell oncocytomas, and sellar ependymomas) is still not definitely settled [59][60][61][62][63].…”

Section: Discussionmentioning

confidence: 99%

“…Notably, the notion of TTF-1 immunopositive sellar tumors is not widespread. Several recent such cases have not been so tested [63,69,70,81,82].…”

Section: Discussionmentioning

confidence: 99%

TTF-1-Expressing Supratentorial Embryonal Tumors (PNET): A Clinicopathologic Study of Two Cases and Literature Review of TTF-1-Positive Primary Brain Tumors

Bisceglia¹,

Pizzolitto²,

Parracino³

et al. 2018

obm neurobiol

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“…Pituitary ependymoma: At present, only 10 pituitary ependymoma cases with TTF-1 positive have been reported in the English literature. All these cases located in the pituitary(7). Ependymoma of the third ventricle: The ependymoma of the third ventricle was positive for TTF-1 in the literature reported.…”

mentioning

confidence: 86%

Chordoid Glioma of the Third Ventricular with Rare Patterns and Mutation in PRKCA: a case report and review of literature

Ma¹,

zhu

wang

et al. 2020

Preprint

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Background: Chordoid gliomas are rare, low-grade neoplasms of the third ventricle. In the updated 4th edition of the 2016 WHO classification of tumours of the CNS, it described some three less common histological patterns and rare tissue patterns. Case presentation:Here we reported a case with all the uncommon patterns. It was a 52-year-old woman with dizziness and blurred vision. Imaging showed a solid tumor located in the third ventricle with a well-circumscribed border. Histological, almost tumor cells formed into atypical glands with different sizes and irregular shapes in an abundant of solid or loosely collagen matrix. Some tumor cells formed into papillary patterns, micro-papillary patterns. pseudoglandular patterns. Some focal tumor cells were spindle-shape. Only few epithelioid tumor cells formed into clusters and cords embedded into a myxoid stroma like the chordoma. No anaplastic features were identified in any lesion. Immunohistochemically, all the tumor cells were strong reactivity for TTF-1. Some tumor cells strong but focal reactivity for GFAP, NEU-N, and CD34. It showed a recurrent D463H missense mutation in PRKCA. All these findings confirm that the diagnosis was chordoid glioma of the third ventricular. Conclusions: There may be lots of histopathological features in one chordoid glioma case. It maybe suggested that PRKCA D463H mutation and TTF-1 positive may help to diagnose it.

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Pituitary Ependymoma: A Case Report and Review of the Literature

Cited by 14 publications

References 28 publications

Case Report: Sellar Ependymomas: A Clinic-Pathological Study and Literature Review

Case Report: Sellar Ependymomas: A Clinic-Pathological Study and Literature Review

TTF-1-Expressing Supratentorial Embryonal Tumors (PNET): A Clinicopathologic Study of Two Cases and Literature Review of TTF-1-Positive Primary Brain Tumors

Chordoid Glioma of the Third Ventricular with Rare Patterns and Mutation in PRKCA: a case report and review of literature

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