Pituitary-Gonadal, Pituitary-Adrenocortical Hormones and IL-6 Levels Following Long-Term Magnesium Supplementation in Male Students

Zogović, Dušanka; Pešić, Vesna; Dmitrašinović, Gordana; Dajak, Marijana; Plećaš, B.; Batinić, Bojan; Popović, Dejana; Ignjatović, Svetlana

doi:10.2478/jomb-2014-0016

Cited by 15 publications

(12 citation statements)

References 36 publications

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“…Our results for rugby players before Mg supplementation corroborate these findings. One of our previous trials on a male student population showed that chronic magnesium supplementation caused decrease in serum cortisol level that was also accompanied by reduction in IL-6 level ( 25 ). There is a substantial amount of data pointing to the role of Mg in cytokine production as a part of HPA axis disturbance and/or immune response.…”

Section: Discussionmentioning

confidence: 99%

ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation

Dmitrašinović¹,

Pešić²,

Stanić³

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundPhysical exercise activates the hypothalamo-pituitary-adrenal (HPA) axis and induces the body’s inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players.MethodsRugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point.ResultsThere was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p < 0.01) and at the day of competition (Game) (p < 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p < 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p < 0.01).ConclusionsThese results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.

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Section: Discussionmentioning

confidence: 99%

ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation

Dmitrašinović¹,

Pešić²,

Stanić³

et al. 2016

Journal of Medical Biochemistry

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“…In a double-blind, randomized trial of 46 healthy adults aged 60–75 years, magnesium supplementation (magnesium 500 mg per day administered as magnesium oxide tablets for 8 weeks) improved subjective measures of insomnia, which is recognized as a symptom of stress [8, 9]. Magnesium supplementation over a period of one month (magnesium 500 mg per day in a magnesium oxide tablet) has also been shown to significantly decrease basal serum cortisol concentrations, a biomarker of stress, in students [10].…”

Section: Introductionmentioning

confidence: 99%

Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial

et al. 2018

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IntroductionAnimal and clinical studies suggest complementary effects of magnesium and high-dose pyridoxine (vitamin B6) on stress reduction. This is the first randomized trial evaluating the effects of combined magnesium and vitamin B6 supplementation on stress in a stressed population with low magnesemia using a validated measure of perceived stress.MethodsIn this Phase IV, investigator-blinded trial (EudraCT: 2015-003749-24), healthy adults with Depression Anxiety Stress Scales (DASS-42) stress subscale score >18 and serum magnesium concentration 0.45 mmol/L–0.85 mmol/L, were randomized 1:1 to magnesium–vitamin B6 combination (Magne B6 [Mg–vitamin B6]; daily dose 300 mg and 30 mg, respectively) or magnesium alone (Magnespasmyl [Mg]; daily dose 300 mg). Outcomes included change in DASS-42 stress subscale score from baseline to Week 8 (primary endpoint) and Week 4, and incidence of adverse events (AEs).ResultsIn the modified intention-to-treat analysis (N = 264 subjects), both treatment arms substantially reduced DASS-42 stress subscale score from baseline to Week 8 (Mg–vitamin B6, 44.9%; Mg 42.4%); no statistical difference between arms was observed (p>0.05). An interaction (p = 0.0097) between baseline stress level and treatment warranted subgroup analysis (as per statistical plan); adults with severe/extremely severe stress (DASS-42 stress subscale score ≥25; N = 162) had a 24% greater improvement with Mg–vitamin B6 versus Mg at Week 8 (3.16 points, 95% CI 0.50 to 5.82, p = 0.0203). Consistent results were observed in the per protocol analysis and at Week 4. Overall, 12.1% of Mg–vitamin B6 treated and 17.4% of Mg-treated subjects experienced AEs potentially treatment related.ConclusionsThese findings suggest oral Mg supplementation alleviated stress in healthy adults with low magnesemia and the addition of vitamin B6 to Mg was not superior to Mg supplementation alone. With regard to subjects with severe/extremely severe stress, this study provides clinical support for greater benefit of Mg combined with vitamin B6.

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“…Hirsch’s so-called H index was proposed as an alternative to other bibliometric indicators - such as the number of publications, the average number of citations and the sum of all citations ( 97 ) - and is defined as follows: “A scientist has index h if h of his or her Np papers have at least h citations each and the other (Np - h) papers have ≤ h citations each” ( 102 ). All papers by a scientist that have at least h citations are called the “Hirsch core” ( 13 ). An H-index of 5 means that a scientist has published five papers that each have at least five citations ( 97 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Web of Science and Pubmed Indexed Medical Journals Published in Former Yugoslav Countries

Mašić¹,

Janković²

2020

Med Arch

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Introduction: The source of scientific information, methods for their evaluation, and methodology of their use are critical for serious scientific research and publishing of the scientific research results. Certain methodological principles should be inexcusably followed when designing clinical or observational research to avoid bias and presentation of results that do not reflect the truth about the phenomenon that is the object of the study. Aim: The aim of this study was to compare the methodological quality of clinical trials and observational studies published in medical journals from ex-Yugoslav countries indexed in Web of Science (WoS) and Pubmed/MEDLINE. Methods: Clinical studies published in medical journals of ex-Yugoslav countries were retrieved from the WoS and Pubmed database, and the sample for analysis was randomly chosen from the retrieved publications. The rate of the most common errors in the design of clinical/observational studies was established by a careful reading of the sampled publications and their checking against predefined criteria. Results: Number and percent of the evaluated studies that failed to meet each of the methodological criteria tested, number of the evaluated criteria not satisfied per database and number of studies that satisfied more than 4 criteria were analyzed per database. When explanatory potential of journal impact factor, number of citations, time elapsed from publication and a database where a journal is referred were tested by linear regression in regard to the number of methodological criteria satisfied per study, the linear regression model was obtained by backward deletion method and achieved R2 adjusted of 0.166 (F=13.827, df1 = 2, df2 = 127, p=0.000). The methodological quality of studies was directly related to impact factor of the journals (B = 0.976, 95% confidence interval 0.539 – 1.413, p=0.000) and inversely with the database where a journal is referred (B =–0.444, 95% confidence interval–0.824 – -0.064, p = 0.022). Each additional unit of impact factor increased number of satisfied methodological criteria for about 1, while referring a journal only in WoS decreased number of satisfied criteria for 0.45 points in comparison with journals referred in both WoS and Pubmed/MEDLINE, and for 0.9 points in comparison to journals referred only in MEDLINE. Conclusion: Methodological and scientometric quality of clinical studies published in medical journals from ex-Yugoslav region varies significantly, and the variations are higher in journals referenced only in WoS than in journals referenced in Pubmed/MEDLINE only, or in both Pubmed and Web of Science databases.

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Pituitary-Gonadal, Pituitary-Adrenocortical Hormones and IL-6 Levels Following Long-Term Magnesium Supplementation in Male Students

Cited by 15 publications

References 36 publications

ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation

ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation

Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial

Comparative Analysis of Web of Science and Pubmed Indexed Medical Journals Published in Former Yugoslav Countries

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