Pituitary hormone-producing cells after estradiol application in rat models of menopause

Milošević, Verica; Ajdžanović, Vladimir

doi:10.5937/sjecr1403115m

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Gonadotrophs are immunoreactive for both FSH and LH or only for one of these hormones. In females half of these cells are bihormonal, while in males almost all cells contain both hormones (55)(56)(57)(58)(59).…”

Section: Pituitary Hormone-producing Cellsmentioning

confidence: 99%

The Morpho-Functional Parameters of Rat Pituitary Hormone Producing Cells After Genistein Treatment

Trifunović

Milošević

2018

Macedonian Veterinary Review

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Phytoestrogens are a diverse group of steroid–like compounds that occur naturally in many plants. There are various types of phytoestrogens, including the best-researched isoflavones which are commonly found in soy. The consumption of soy products has many health benefits, including protection against breast cancer, prostate cancer, menopausal symptoms, heart disease and osteoporosis. In contrast, use of hormonally active compounds-isoflavones may unfortunately interfere with the endocrine system and can have far-reaching consequences. Genistein, the most abundant soy-bean derived isoflavone, possesses a ring system similar to estrogens and acts through an estrogen receptor (ER)-mediated mechanism, by increasing or decreasing the transcription of ER-dependent target genes. Also, genistein can act on cells through ER non-dependent mechanisms, such as tyrosine kinase inhibitor. The neuroendocrine systems are responsible for the control of homeostatic processes in the body, including reproduction, growth, metabolism and energy balance, and stress responsiveness. It is well known, that estrogen is important for development of the neuroendocrine system in both sexes. At the pituitary level, estrogen is known to affect the regulation of all hormone producing (HP) cells, by direct and/or indirect mechanisms. Due to structural and functional resemblance to estrogen, the question may arise of whether and how genistein affects the morphofunctional features of pituitary HP cells. This review deals with the consequences of genistein’s effects on morphological, stereological and hormonal features of HP cells within the anterior pituitary gland. Transparency on this issue is needed because isoflavones are presently highly consumed. Inter alia, genistein as well as other isoflavones, are present in various dietary supplements and generally promoted as an accepted alternative to estrogen replacement therapy. Potential isoflavone biomedical exploitation is not only limited to estrogen replacement therapy, so it should be treated in a wider context of different ageing symptoms remediation.

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Section: Pituitary Hormone-producing Cellsmentioning

confidence: 99%

The Morpho-Functional Parameters of Rat Pituitary Hormone Producing Cells After Genistein Treatment

Trifunović

Milošević

2018

Macedonian Veterinary Review

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Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats

et al. 2015

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The aim of this study was to assess the effects of genistein (G) and daidzein (D) on the histological, hormonal, and functional parameters of the pituitary-ovarian axis in middle-aged female rats, and to compare these effects with the effects of estradiol (E), commonly used in the prevention and treatment of menopausal symptoms. Middle-aged (12 month old) Wistar female rats subcutaneously received 35 mg/kg of G, or 35 mg/kg of D, or 0.625 mg/kg of E every day for 4 weeks. Each of the treated groups had a corresponding control group. An intact control group was also established. G and D did not change the intracellular protein content within gonadotropic and lactotropic cells, but vacuolization was observed in all the cell types. In contrast, E caused an inhibition of gonadotropic and stimulation of lactotropic cells. Also, ovaries of middle-aged female rats exposed to G or D have more healthy primordial and primary follicles and less atretic follicles. E treatment in the ovaries had a mostly negative effect, which is reflected by the increased number of atretic follicles in all tested classes. G and D provoked decrease in CuZnSOD and CAT activity, while E treatment increased MnSOD and decreased CuZnSOD and GSHPx activity. All the treatments increased serum estradiol and decreased testosterone levels, while D and E increased the serum progesterone level. In conclusion, soy phytoestrogens exhibited beneficial effects on pituitary-ovarian function in middle-aged female rats, as compared to estradiol.

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Pituitary hormone-producing cells after estradiol application in rat models of menopause

Cited by 2 publications

References 14 publications

The Morpho-Functional Parameters of Rat Pituitary Hormone Producing Cells After Genistein Treatment

The Morpho-Functional Parameters of Rat Pituitary Hormone Producing Cells After Genistein Treatment

Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats

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