Pituitary Hyperplasia Due to Hypothyroidism

Okuno, T; Sudo, Masakatsu; Momoi, T; Takao, Toshifumi; M, Ito; Konishi, Yukiko; Yoshioka, M; Suzuki, Junya; Nakano, Yujiro

doi:10.1097/00004728-198010000-00004

Cited by 33 publications

(11 citation statements)

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“…Furthermore, ES has been described following the regression of pituitary hyperplasia secondary to gland failure of the peripheral zone in hypothyroidism [4][5][6], hypogonadism [7][8][9], Addison's disease [10,11], and polyglandular failure syndromes with hypofunction [12].…”

Section: Introductionmentioning

confidence: 99%

Empty sella and primary autoimmune hypothyroidism

et al. 2009

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In order to assess the association between empty sella (ES) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis. We retrospectively studied all patients with presumed ES diagnosed in the last 20 years, most of whom were treated by our Endocrinology Department. Subjects with a known etiology were excluded. Incomplete records or those with a doubtful diagnosis were also excluded. A total of 56 subjects were included in the study. ES was diagnosed by pituitary MRI. The measurement of free T4, TSH, and antithyroid antibodies (TPOAb and TgAb) was assayed using commercial kits. The cases of hypothyroidism obtained were compared with those in another group of similar patients, diagnosed with diabetes mellitus type 2, through chi2 test. A total of 15 (26.78%) patients of 56 with ES had autoimmune thyroid disease (subclinical or clinical hypothyroidism). Primary hypothyroidism with negative antithyroid autoantibodies was found in a further 13 patients (23.21%). The 46.42% of ES had primary hypothyroidism; this result had obtained a statistically significant difference when compared to the ratio obtained in the group of diabetes mellitus type 2 (P < 0.0029). There is an important association between ES and autoimmune thyroid disease, which reached 26.78% in our series. We suggest the possibility of a common pathogenesis for certain cases of ES and autoimmune thyroid disease, with the end point of ES in the pituitary, and atrophy in the thyroid gland.

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Section: Introductionmentioning

confidence: 99%

Empty sella and primary autoimmune hypothyroidism

et al. 2009

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“…fancy in five patients, with onset between the ages of 2 and 10 years in the rest. The approximate duration of symptoms ranged from 3 to 10 years (mean [±SD],6.95±2.91 years), suggesting a delay in diagnosis.All the children had growth retardation and de¬ layed skeletal maturation…”

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confidence: 99%

Pituitary Enlargement on Magnetic Resonance Imaging in Congenital Hypothyroidism

Desai¹

1996

Arch Pediatr Adolesc Med

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“…MRI is superior to CT scan and a follow up imaging will further help to monitor the size of the gland. (4,6,(18)(19)(20)(21)(22) Detail thyroid functions are the mainstay of diagnosis as it will show decrease in the levels of serum T3 and T4 but greatly elevated serum TSH levels. (2,3,6) One the diagnosis of pituitary hyperplasia secondary to primary hypothyroidism is suspected the patients can be managed with adequate hormone replacement with L-thyroxine (25 to 300 mcg/day) and in most of the cases this will result in relief of symptoms and regression of pituitary hyperplasia within a few months.…”

Section: Discussionmentioning

confidence: 99%

Primary hypothyroidism masquerading pituitary macroadenoma

Agrawal¹,

Reddy²,

Rao³

et al. 2014

Romanian Neurosurgery

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Diffuse and reactive pituitary gland enlargement secondary to primary hypothyroidism is an uncommon occurrence and that can masquerade many pituitary disorders. In present article, we report a case of 19 year female severe hypothyroidism presenting with diffuse enlargement of pituitary gland and hyperprolactinemia and review the clinical importance of this entity. Knowledge of this entity is very important to avoid unnecessary surgery and irreversible complications in this sub-group of patients.

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Pituitary Hyperplasia Due to Hypothyroidism

Cited by 33 publications

References 0 publications

Empty sella and primary autoimmune hypothyroidism

Empty sella and primary autoimmune hypothyroidism

Pituitary Enlargement on Magnetic Resonance Imaging in Congenital Hypothyroidism

Primary hypothyroidism masquerading pituitary macroadenoma

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