Pituitary Hyperplasia

Scheithauer, B. W.; Horváth, Éva; Lloyd, R.V.; Kovacs, K

doi:10.1097/00132583-199811000-00003

Cited by 7 publications

(35 citation statements)

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“…ism (6). Therefore, mild to moderate hyperprolactinemia may occur in about three-quarters of patients (8), and it was also demonstrated in our case.…”

Section: Discussionsupporting

confidence: 79%

“…Pituitary hyperplasia is defined as a nonneoplastic increase in the number of one or more functionally distinct types of pituitary cells (6). It can occur as a normal response to physiological stimuli like pregnancy or as a pathological condition (6).…”

Section: Discussionmentioning

confidence: 99%

“…It can occur as a normal response to physiological stimuli like pregnancy or as a pathological condition (6). Thyrotrophic hyperplasia results from the loss of thyroxine feedback inhibition and the subsequent overproduction of thyrotropin-releasing hormone (TRH) (7).…”

Section: Discussionmentioning

confidence: 99%

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Pituitary hyperplasia mimicking macroadenoma secondary to primary hypothyroidism

Toromanović

Tahirović

2016

Pedaiatr Today

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Objective -We aim to emphasize the importance of extensive endocrine workup in cases of pituitary masses. Case report -We report on a case of pituitary thyrotrophic hyperplasia in a 12-year-old girl who was thought to have a pituitary macroadenoma with suprasellar extension. The main complaint was headache, while other symptoms of hypothyroidism were present, but weren't recognised. Hormonal testing revealed low total thyroxine (<12.8 nmol/l) and high TSH (310.5 mIU/l) levels, and hyperprolactinemia (prolactin level at 1680 mIU/l). Based on the clinical history, laboratory data, and MRI, a diagnosis of pituitary hyperplasia secondary to primary hypothyroidism, consequent to chronic autoimmune thyroiditis, was made. Therapy with levothyroxine was initiated at 50 µg/day and gradually increased to 75 µg daily. After three months of thyroxine replacement, she was clinically and biochemically euthyroid. A follow-up MRI, 4 months after thyroxine replacement was initiated, showed complete resolution of the mass, and normal pituitary gland. Conclusion -Primary hypothyroidism should be considered in the differential diagnosis of pituitary masses. Multidisciplinary assessment in these cases will help to avoid delays in diagnosis and prevent unnecessary surgery.

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“…ism (6). Therefore, mild to moderate hyperprolactinemia may occur in about three-quarters of patients (8), and it was also demonstrated in our case.…”

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pituitary hyperplasia mimicking macroadenoma secondary to primary hypothyroidism

Toromanović

Tahirović

2016

Pedaiatr Today

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“…There are reports of patients with enlarged pituitary gland submitted by mistake to surgery in the best European centers, as pituitary adenomas, although the pathology proved to be physiological pituitary hyperplasia (6). Pituitary hyperplasia is defined as a nonneoplastic increase of one or more functionally distinct types of pituitary cells (7,8). Any cell population within the pituitary gland can undergo hyperplasia and sometime adaptive transdifferentiation (9).…”

Section: Introductionmentioning

confidence: 99%

Reticular fibers network discriminates between normal hypophysis and pituitary adenomas

Ceauşu¹

2010

Acta Endo (Buc)

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Background. Usually, silver stain is needed to differentiate between normal or hyperplastic hypophysis and pituitary adenomas. Many papers reported the lack of reticular fibers network as mandatory for pituitary adenoma diagnosis.Aim. Differences between the architecture of reticular fibers in normal pituitary and pituitary adenomas.Methods. Gordon-Sweet silver staining of pituitary specimens, prelevated during pituitary surgery performed in 138 patients with the endocrine and imagistic diagnosis of pituitary macro-adenomas.Results. Pituitary specimens of pituitary adenomas was confirmed in 133 cases; 3 specimens were with normal pituitary tissue, 1 with pituitary hyperplasia, 1 with pituitary apoplexy. Twelve of 133 pituitary adenomas specimens were associated also with normal pituitary tissue. There was a loss of acinar network of reticular fibres in 115 cases, but the present study describes the persistence of reticular fibers networks in 18 (13.53%) of 133 pituitary adenomas. We identified five distribution patterns of remanent reticular fibers network in pituitary adenomas using silver staining.Conclusion. Persistence of reticular fibers in a small number of pituitary adenomas could be a possible pitfall in the discrimination between the normal hypophysis and pituitary adenoma.

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“…Pituitary hyperplasia has been known for a long period of time and yet remains poorly understood. It is an uncommon condition that is inadequately studied, difficult to diagnose and under-diagnosed 1,2 . The aim of this review is to shed light on this condition and to discuss it based on the knowledge of the past aided by the recent advances in the fields of radiology, pathology and cellular and molecular biology.…”

Section: Introductionmentioning

confidence: 99%

Pituitary Hyperplasia

Al-Gahtany¹,

Horváth²,

Kovács³

2003

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Pituitary hyperplasia is rare, difficult to diagnose and sometimes controversial. The hyperplasia could be physiologic which is usually reversible, or pathologic which varies in presentation from incidental to tumor like lesion with and without hormonal disturbance. Any pituitary cell is capable of undergoing hyperplasia in the presence of the right stimuli. In this article we summarize the various pathologic and morphologic features of each subtype of pituitary hyperplasia, give an account of the molecular, hormonal and cellular basis of this condition and outline its clinical significance, differential diagnosis and prognosis.

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Pituitary Hyperplasia

Cited by 7 publications

References 0 publications

Pituitary hyperplasia mimicking macroadenoma secondary to primary hypothyroidism

Pituitary hyperplasia mimicking macroadenoma secondary to primary hypothyroidism

Reticular fibers network discriminates between normal hypophysis and pituitary adenomas

Pituitary Hyperplasia

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