Pituitary metastasis: From pathology to clinical and radiological considerations

Kameda-Smith, Michelle; Zhang, E.; Lannon, Melissa; Algird, Almunder; Reddy, Kesava; Lu, Jian‐Qiang

doi:10.1016/j.jocn.2021.09.016

Cited by 13 publications

(15 citation statements)

References 59 publications

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“…Carcinomas to the brain are common, however metastases to the hypothalamic-pituitary region are far less common. 1 Of pituitary metastases, the most common primary tumor sites are lung and breast (both ductal and classic lobular types) which compromise less than 1% of all malignant hypothalamic-pituitary tumors. 2 Such patients may present with diabetes insipidus, cranial nerve palsies or visual field defects, 3 or they may be asymptomatic and remain undiagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…2,8 Kameda-Smith reported generally bleak outcomes for patients with pituitary metastases from a variety of primary carcinomas including breast primaries. 1…”

Section: Discussionmentioning

confidence: 99%

“…The immune-profile was felt to be most compatible with a breast primary, most likely pleomorphic lobular carcinoma based on the morphology and the presence of intracellular mucin. Upon further discussion with the clinicians, it was 1 Rutgers-New Jersey Medical School, Newark NJ discovered that the patient had been diagnosed with pleomorphic lobular carcinoma of the breast 17 years earlier. At that time, at age 36, she was treated with bilateral mastectomies and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Hypothalamus Presenting as a Primary Pituitary Lesion Presenting 17 Years Later-Report of a Case and Review of the Literature

et al. 2022

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Carcinomas metastatic to the brain are common, however, metastatic disease to the hypothalamic- pituitary region is uncommon and account for less than 3.6% of all resected malignant pituitary tumors. Most metastatic disease in that region derives from a lung or breast primary, with both ductal and lobular carcinoma reported. We report what we believe is the first case of pleomorphic lobular carcinoma metastatic to the hypothalamus. This case is also reaffirms that late metastasis from breast cancer should be considered in the differential diagnosis. It is important for the clinician to consider the clinical history of breast cancer, even when remote, in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…2,8 Kameda-Smith reported generally bleak outcomes for patients with pituitary metastases from a variety of primary carcinomas including breast primaries. 1…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Hypothalamus Presenting as a Primary Pituitary Lesion Presenting 17 Years Later-Report of a Case and Review of the Literature

et al. 2022

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“…Pituitary metastases (PMs) are rare, representing only 1% of all operated pituitary tumors, and 0.4% of all metastatic disease [ 1 ]. The first case of PMs was described in 1857, in a patient with pituitary infiltration from a metastatic melanoma [ 2 ].…”

mentioning

confidence: 99%

Pituitary Infiltration by Lymphoma

Tovar-Méndez

Cuenca

Gómez-Pérez

et al. 2022

Journal of the Endocrine Society

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Lymphoma infiltration to pituitary is rare. It represents <0.5% of all reported pituitary metastasis. Here we present a case series of three patients with pituitary metastases from a systemic lymphoma. Also, we performed a literature review of the cases reported. We identified additional 31 cases where non-Hodgkin's lymphoma (NHL) was the most common (n = 28, 90%), with large B-cell NHL the most frequent histological subtype (n = 14, 45%). Central hypothyroidism (n = 21, 67%) was the most frequent pituitary deficiency followed by adrenal insufficiency (n = 19, 61%), and diabetes insipidus (n = 18, 58%). Full endocrine recovery was found in only 12% (n = 4) of patients after treatment, and the MRI showed tumor regression in 22% of them. In our series, two patients were diagnosed with diffuse large B-cell lymphoma, and one had mixed cellularity of classical Hodgkin lymphoma. The mean age was 54 ± 6.92 years. Hypopituitarism and diabetes insipidus were present in all of them, with 100% of mortality because of the advanced systemic disease.

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“…Rare lesions of the sellar region include PAs associated with McCune-Albright syndrome (MAS), or multiple endocrine neoplasia type 1 (MEN1), pituitary carcinomas (PCs), clival chordoma, pituitary metastasis from other tumors, giant invasive PAs, giant CPs, etc. ( 4 , 5 ). These rare lesions of the sellar region present with complex clinical and atypical imaging features.…”

mentioning

confidence: 99%