Pituitary metastasis of solid tumors: 2 cases of different presentation

Cardona-Rovira, Maria Gràcia; Casañ-Fernández, Rosa; Sanz-Gallur, Javier; Almonacid-Folch, Elena; Nadal-Máñez, Alba

doi:10.1016/j.endien.2018.11.012

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Polyuria or polydipsia was reported in nine patients, and DI was confirmed in six of nine patients with available data. Other common symptoms included headache (17), nausea and vomiting (5), and fatigue (4). ere were three patients whose only presenting complaints were headache, nausea, or fatigue.…”

Section: Patient Characteristics and Presentationmentioning

confidence: 99%

Early and isolated breast cancer metastasis to the pituitary: A case report and systematic review

Rasiah

Albakr

Kosteniuk

et al. 2022

Surgical Neurology International

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Background: Pituitary metastases (PMs) arising from breast cancer tend to occur many years following initial diagnosis, and after other systemic metastasis have been identified. Survival is generally considered to be poor. However, there are cases where patients present with an isolated metastatic lesion in the pituitary. Survival in this subset of patients has not been evaluated. We present a case of isolated PM that presented two years after initial diagnosis of breast cancer. We performed a systematic review of 38 breast cancer patients with PM. We report presentation, treatment strategy, and outcomes of breast cancer metastasis to the pituitary and highlight cases of isolated PM. Case Description: A 39 year old female presented with complaints of headache and polydipsia two years after diagnosis with breast cancer. Systemic workup was unremarkable, but brain imaging identified an isolated PM. Transsphenoidal debulking was performed with adjuvant radiation therapy (RT) targeted to the sellar region. Unfortunately, she passed away 9 months later from systemic progression. Conclusion: A total of 38 patients were included systematic review. Of these, 13 had isolated PM. Prevalent signs/ symptoms included visual disturbance, diabetes insipidus (DI), and hypothalamic dysfunction. Patients treated with surgical resection and adjuvant chemotherapy (ChT), or RT had better survival than those treated with resection alone. Patients that receive treatment for isolated PM may survive for many years without progression or recurrence.

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Section: Patient Characteristics and Presentationmentioning

confidence: 99%

Early and isolated breast cancer metastasis to the pituitary: A case report and systematic review

Rasiah

Albakr

Kosteniuk

et al. 2022

Surgical Neurology International

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Section: Introductionmentioning

confidence: 99%

“…2 Although pituitary gland metastases are uncommon, they should be suspected in cases of rapidly progressing tumors, hyperprolactinemia, headache, cranial nerve palsies, or rapid onset diabetes insipidus. 5 Primary pituitary infections occur in normal pituitary glands, while secondary infections occur in patients with preexisting pituitary lesions like pituitary adenoma, Rathke's cleft cyst, craniopharyngioma, or following surgery. Bacterial infections, like mycobacterium tuberculosis, can cause pituitary inflammation leading to secondary hypophysitis.…”

Section: Introduction Pituitary Gland and Causes Leading To Its Abnor...mentioning

confidence: 99%

Utility of F18-FDG PET/CT in the Evaluation of Pituitary Uptake

Stanly,

Sunny,

Benjamin

et al. 2024

World J Nucl Med

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Introduction Pituitary adenoma is the most common disease that affects the gland and may be classified as functional/nonsecretory tumors. Inflammatory/infective causes may also affect the pituitary gland. The 18F-fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) may have an incremental value in assessing these lesions and in determining their clinical significance. Aim This article assesses the utility of F18-FDG PET/CT in detecting and determining clinical profile of pituitary lesions with abnormal uptake. Methodology Retrospective analysis of all patients who underwent F18-FDG PET/CT from January 2015 to January 2023 was done. Those with abnormal pituitary uptake (standardized uptake value [SUV] > 2.5) were included in the study. SUV value along with relevant anatomical details, biochemical parameters, histopathological details, and follow-up imaging were analyzed. Results Among 15,085 studies, a total of 36 patients (21 males/15 females, average age 47.36 years, range: 17–75 years) with pituitary uptake (0.23%) were included. Out of 36 patients, causes are primary pituitary tumor (21/36, 58%), tubercular hypophysitis (3/36, 8%), lymphocytic hypophysitis (2/36, 6%), lymphomatous involvement (2/36, 6%), autoimmune hypophysitis (1/36, 3%), questionable significance/incidental (4/36, 11%), and metastasis (3/36, 8%)—one each from neuroendocrine tumor ileum, chondrosarcoma, and adenocarcinoma lung. There was no difference in the SUV range between the different etiologies.Among 21 patients with pituitary tumor, biochemical evaluation was done in 19 patients. Two patients were lost to follow-up and did not have biochemical evaluation. Among them, 8 underwent endoscopic transsphenoidal radical excision and 1 patient had PET-CT-guided stereotactic radiosurgery alone. In another 8 patients who had prior endoscopic transsphenoidal radical excision, uptake was noted as residual lesion on PET-CT. Of them, 3 underwent subtotal excision and 5 had PET-CT-guided stereotactic radiosurgery. Biopsy was done in 14 patients, of which 11 were macroadenoma and 3 were microadenoma. Overall, magnetic resonance imaging (MRI) brain was performed in 22 of them and the findings were concordant with F18-FDG PET/CT. Conclusion F18-FDG PET/CT is a useful modality in the evaluation of pituitary uptake. It has an incremental value along with MRI brain and biochemical parameters and is useful for follow-up. Due to its high diagnostic accuracy, it is particularly useful in those with suspected residual/recurrent adenomas.

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Pituitary metastasis of solid tumors: 2 cases of different presentation

Cited by 2 publications

References 8 publications

Early and isolated breast cancer metastasis to the pituitary: A case report and systematic review

Early and isolated breast cancer metastasis to the pituitary: A case report and systematic review

Utility of F18-FDG PET/CT in the Evaluation of Pituitary Uptake

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