Pituitary, Ovarian, and Adrenal Hormone Responses to Marathon Running*

Bonen, A.; Ha, Keizer

doi:10.1055/s-2008-1025723

Cited by 36 publications

(16 citation statements)

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“…Conversely, DHAS remained at a high level 2 h after exercise, contrary to other steroids, the levels of which had decreased at this time. These results agree well with the characteristics of the above-mentioned kinetics of DHAS, although they were not discussed in this way (5).…”

supporting

confidence: 82%

Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones

Lac

Marquet

Chassain³

et al. 1999

Journal of Applied Physiology

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Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones. J. Appl. Physiol. 87(1): 183-188, 1999.-This study presents the reactions of adrenocorticosteroids (cortisol and aldosterone) and sex steroids [testosterone, androstenedione, and dehydroepiandrosterone and its sulfate (DHAS)] 1) to a dexamethasone (Dex) treatment, which is expected to lower steroid levels via the ACTH blockade, and 2) to an exercise bout at maximal O 2 consumption, which is expected to increase steroid production via ACTH stimulation. Consistent with the decrease in ACTH, all steroids except testosterone reacted negatively to Dex, independently of the dose (0.5 and 1.5 mg administered twice daily for 4.5 days). After exercise, plasma ACTH rose to 600% of basal value, resulting in a significant increase in aldosterone and adrenal androgens, but cortisol and DHAS were unaffected. This apparently surprising result can be explained by differences in peripheral metabolism: a theoretical calculation predicted that after 15 min the increase in hormone concentration may only reach 12% for cortisol and 2% for DHAS. For cortisol and adrenal androgens, assays were carried out using plasma and saliva. The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection. dexamethasone suppression test; exercise; adrenal androgens; cortisol; saliva IN LINE WITH OUR OTHER STUDY examining the effects of dexamethasone (Dex) on bioenergetics and hydromineral regulation in healthy men during exercise, this study was intended to clarify the effects of Dex administration as well as exercise on adreno-and sex steroids.

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supporting

confidence: 82%

Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones

Lac

Marquet

Chassain³

et al. 1999

Journal of Applied Physiology

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“…Among premenopausal women, the mechanism by which physical activity affects steroidal sex hormones has been well studied through the examination of the effects of exercise on adrenocortical responses and the menstrual cycle, often with regard to high-intensity physical activity among women athletes. Physical activity has acute as well as longerterm effects on steroid sex hormones: proandrogens (dehydroepiandrosterone and dehydroepiandrosterone sulfate), androgens (testosterone and androstenedione), and estrogens (estradiol) through its action on the hypothalamic-pituitaryadrenal axis and the hypothalamic-pituitary-gonadal axis (9,(27)(28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Usual Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: The European Prospective Investigation into Cancer–Norfolk Population Study

Chan

Dowsett

Folkerd

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Short-term trials indicate that intensive physical activity may influence endogenous sex hormone concentrations. However, the relationship between usual daily physical activity and endogenous hormones in postmenopausal women in the general population is still uncertain. Objective and Methods: To determine the relationship between usual physical activity and endogenous sex hormones in postmenopausal women. A cross-sectional population-based study of 2,082 postmenopausal women ages 55 to 81 years, residing in the general community of Norfolk, United Kingdom, and not currently using hormone replacement therapy were chosen to participate. Physical activity in the past 1 year was assessed using a validated questionnaire, and endogenous sex hormone and sex hormone -binding globulin (SHBG) concentrations were determined. Results: Usual physical activity levels were inversely associated with circulating concentrations of testosterone and estradiol, testosterone/SHBG ratio, and positively associated with SHBG. These associations were only slightly atten-

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“…However, further investigation is required in the field of female exercise physiology. The few available studies in this field are usually not well controlled, due to the confounding variables related to the menstrual cycle, the use of contraceptives, and the ecological nature of many studies (Baker et al 1982;Bonen and Keizer 1987;Filaire et al 1998). In women, the basal concentrations of testosterone and DHEA-s in plasma are influenced by hormonal changes in the menstrual cycle and the use of oral contraceptives (OC) (Abraham 1974;Coenen et al 1995Coenen et al , 1996Massafra et al 1999;Murphy et al 1990;Wiegratz et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women

et al. 2009

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The objective of this study was to ascertain the effects of menstrual cycle, oral contraception, and training status on the exercise-induced changes in circulating DHEA-sulphate and testosterone in young women. Twenty-eight healthy women were assigned to an untrained group (n = 16) or a trained group (n = 12) depending on their training background. The untrained group was composed of nine oral contraceptive users (OC+) and seven eumenorrheic women (OC-). The trained group was composed of OC+ subjects only. All the OC+ subjects were taking the same low-dose oral contraception. Three laboratory sessions were organised in a randomised order: a prolonged exercise test until exhaustion, a short-term exhaustive exercise test, and a control session. Blood specimens were collected before, during and after the exercise tests and at the same time of the day during the control session. Basal circulating testosterone was significantly lower in trained as compared to untrained subjects. In all subjects, the prolonged exhaustive exercise induced a significant increase in circulating DHEA-s and testosterone. The short-term exercise induced a significant increase in circulating DHEA-s in untrained eumenorrheic and in trained OC users only. Menstrual phases in OC- did not influence the responses. It was found that exhaustive physical exercise induced an increase in circulating DHEA-s and testosterone in young women. Oral contraception may limit short-term exercise-induced changes.

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Pituitary, Ovarian, and Adrenal Hormone Responses to Marathon Running*

Cited by 36 publications

References 0 publications

Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones

Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones

Usual Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: The European Prospective Investigation into Cancer–Norfolk Population Study

Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women

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