Pituitary–ovary–spleen axis in ovulation

Oakley, Oliver R.; Frazer, Michele L.; Ko, Che Myong

doi:10.1016/j.tem.2011.04.005

Cited by 39 publications

(26 citation statements)

References 117 publications

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“…Abd-Allah et al assessed the action of the mesenchymal cells in chemically induced ovarian failure. This animal is also an excellent model for polycystic ovarian syndrome as described by Oakley et al (2011).…”

Section: Discussionmentioning

confidence: 99%

Sexual Determination and Differentiation During Embryonic and Fetal Development of New Zealand Rabbit Females

et al. 2018

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SUMMARY:The aim of this study was to know the embryonic and fetal development of the female rabbit genital system (Oryctolagus cuniculus), describing its main phases and the moment of sexual differentiation. Eleven pregnant New Zealand female rabbits were used in different gestational phases. The day of coitus was determined as day 0. For each stage a minimum of two animals was considered. The samples were obtained every two days from the ninth day post-coitus (dpc) until the 28 th dpc. The gestational period was divided in two: animals with undifferentiated sex (group 1) and animals with differentiated sex (group 2). The ages of embryos and fetuses were estimated through the crown-rump method. Subsequently, embryos and fetuses were dissected, fixed and processed to be embedded in paraffin (Histosec). The histological analysis was performed on sections stained with hematoxylin and eosin. Immunohistochemical analysis to determine sexual differentiation was performed on samples from the 16 th , 18 th and 28 th dpc. Desert Hedgehog (Dhh) and Indian Hedgehog (Ihh) primary antibodies, respectively, were used to identify cells of the male and female germinal epithelium. The immunohistochemical results showed that at the 16 th dpc, female sexual differentiation was evident, since positive expression of the Ihh protein was observed. Sexual differentiation was obtained through histological analysis on the 18 th dpc and through anatomical observation of the external genitalia on the 24 th dpc. Knowing the characteristics of the embryonic and fetal development of the female rabbit genital system as well as the moment of sexual differentiation make it possible to establish bases for future research that address the physiology and pathology of these organs. Thus, any alteration in the chain of events of sexual determination and differentiation must search for an explanation from the knowledge of the possible normal mechanisms affected.

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Section: Discussionmentioning

confidence: 99%

Sexual Determination and Differentiation During Embryonic and Fetal Development of New Zealand Rabbit Females

et al. 2018

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“…Each endocrine organ has communication and a close relationship with one another. The pituitaryovary-spleen axis plays a significant role in ovulation (Oakley et al, 2011;Strauss and Steinkampf, 1995). Any endocrine disorders that significantly affect any of these organs would disrupt reproduction, resulting in infertility (Luk, 2011).…”

Section: Causes Of Female Infertilitymentioning

confidence: 99%

Nutraceuticals in Reproductive and Developmental Disorders

Singh¹

2016

Nutraceuticals

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“…However, this concept has been challenged because the presumed pressure increase at the time of follicle rupture has never been documented (Espey and Lipner, 1963;Rondell, 1964). Instead, more attention has focused on the view that ovulation results from the proteolytic degradation of the follicular wall, which is supported by the functional presence of matrix metalloproteinases/plasminogen activators and inflammatory leukocytes in the ovary (Brannstrom and Enskog, 2002;Curry and Osteen, 2003;Oakley et al, 2010Oakley et al, , 2011Richards et al, 2002).…”

Section: Ovulatory Regulationmentioning

confidence: 99%

Why two endothelins and two receptors for ovulation and luteal regulation?

Meidan

Bridges

2012

Life Sciences

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The ovary is a dynamic organ that undergoes cyclic structural and functional changes. Structurally, the internal architecture of the ovary constantly changes as follicles grow, rupture and transform into corpora lutea in a cyclical manner. Functionally, a variety of regulatory ovarian hormones are sequentially produced, and eggs are periodically released. As a highly vascularized organ, the ovarian structures and functions change in response to external stimuli that include but are not limited to pituitary gonadotropins. Following stimulation, the ovary synthesizes and releases autocrine and paracrine signals that play unique roles in regulating its function. Recent studies have identified endothelins as local regulators in the ovary that modulate multiple cyclic events, such as follicle growth, steroidogenesis, oocyte maturation, ovulation, corpus luteum formation and luteolysis. Interestingly, in all mammalian species examined to date, a common observation has been made: the ovary produces two pharmacologically similar endothelins (ET-1 and ET-2) but expresses two functionally different endothelin receptors (ET(A) and ET(B)) that often give rise to opposite physiological outcomes following activation by an endothelin. In this review, the physiological significance of the presence of the two ligand-two receptor endothelin system in the ovary will be discussed.

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Pituitary–ovary–spleen axis in ovulation

Cited by 39 publications

References 117 publications

Sexual Determination and Differentiation During Embryonic and Fetal Development of New Zealand Rabbit Females

Sexual Determination and Differentiation During Embryonic and Fetal Development of New Zealand Rabbit Females

Nutraceuticals in Reproductive and Developmental Disorders

Why two endothelins and two receptors for ovulation and luteal regulation?

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