Pituitary Portal Plasma Levels of Oxytocin during the Estrous Cycle, Lactation, and Hyperprolactinemia

Sarkar, Dipak K.; Frautschy, Sally A.; Mitsugi, Naoto

doi:10.1111/j.1749-6632.1992.tb34370.x

Cited by 34 publications

(15 citation statements)

References 64 publications

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“…For example, estradiol administration is associated with increases in electrical excitability of OT-producing neurons in the PVN (Akaishi and Sakuma, 1985) and increases in the rate of transcription of the OTR gene (via the effect of estradiol on the gene’s promoter region) (Quinones-Jenab et al, 1997). Fluctuations in estradiol levels during the estrous cycle produce parallel fluctuations in plasma OT and OTR mRNA levels (Bale et al, 1995; Ho and Lee, 1992; Sarkar et al, 1992; for a review, see Choleris et al, 2008). …”

Section: Biological Determinants Of Motivation In a Social Contextmentioning

confidence: 99%

Oxytocin and social motivation

Gordon

Martin

Feldman

et al. 2011

Developmental Cognitive Neuroscience

167

114

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Humans are fundamentally social creatures who are ‘motivated’ to be with others. In this review we examine the role of oxytocin (OT) as it relates to social motivation. OT is synthesized in the brain and throughout the body, including in the heart, thymus, gastrointestinal tract, as well as reproductive organs. The distribution of the OT receptor (OTR) system in both the brain and periphery is even more far-reaching and its expression is subject to changes over the course of development. OTR expression is also sensitive to changes in the external environment and the internal somatic world. The OT system functions as an important element within a complex, developmentally sensitive biobehavioral system. Other elements include sensory inputs, the salience, reward, and threat detection pathways, the hypothalamic-pituitary-gonadal axis, and the hypothalamic-pituitary-adrenal stress response axis. Despite an ever expanding scientific literature, key unresolved questions remain concerning the interplay of the central and peripheral components of this complex biobehavioral system that dynamically engages the brain and the body as humans interact with social partners over the course of development.

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Section: Biological Determinants Of Motivation In a Social Contextmentioning

confidence: 99%

Oxytocin and social motivation

Gordon

Martin

Feldman

et al. 2011

Developmental Cognitive Neuroscience

167

114

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show abstract

“…Hyperprolactinaemia is an established cause of infertility. Prolactin suppresses both frequency and amplitude of luteinising hormone (LH) pulses (149)(150)(151)(152) and reduces GnRH secretion into the portal blood (153)(154)(155)(156). Prolactin can also act in the pituitary gland to suppress LH secretion (157)(158)(159)(160)(161).…”

Section: Suppression Of Fertilitymentioning

confidence: 99%

Prolactin: A Pleiotropic Neuroendocrine Hormone

Grattan

Kokay

2008

J Neuroendocrinology

277

177

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The neuroendocrine control of prolactin secretion is unlike that of any other pituitary hormone. It is predominantly inhibited by the hypothalamus and, in the absence of a regulatory feedback hormone, it acts directly in the brain to suppress its own secretion. In addition to this short‐loop feedback action in the brain, prolactin has been reported to influence a wide range of other brain functions. There have been few attempts to rationalise why a single hormone might exert such a range of distinct and seemingly unrelated neuroendocrine functions. In this review, we highlight some of the original studies that first characterised the unusual features of prolactin neuroendocrinology, and then attempt to identify areas of new progress and/or controversy. Finally, we discuss a hypothesis that provides a unifying explanation for the pleiotrophic actions of prolactin in the brain.

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“…Most of the OT present in the median eminence is produced in magnocellular neurons of the paraventricular (PVN (162» and supraoptic nuclei (SON (163» with some produced in parvocellular neurons (84,162,(164)(165)(166)(167)(168)(169)(170). Parvocellular neurons project to the external lamina of the median eminence (171,172) and they increase in number after PVN lesions (171), suggesting they play a physiological role.…”

Section: Ot Control Of Acth Secretionmentioning

confidence: 99%

Patterns of ACTH Secretagog Secretion in Response to Psychological Stimuli

1996

J Neuroendocrinology

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Pituitary Portal Plasma Levels of Oxytocin during the Estrous Cycle, Lactation, and Hyperprolactinemia

Cited by 34 publications

References 64 publications

Oxytocin and social motivation

Oxytocin and social motivation

Prolactin: A Pleiotropic Neuroendocrine Hormone

Patterns of ACTH Secretagog Secretion in Response to Psychological Stimuli

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