2022
DOI: 10.3389/fendo.2022.868558
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Pituitary Stalk Thickening: Causes and Consequences. The Children’s Memorial Health Institute Experience and Literature Review

Abstract: BackgroundPituitary stalk thickening (PST) is a rare abnormality in the pediatric population. Its etiology is heterogeneous. The aim of the study was to identify important clinical, radiological and endocrinological manifestations of patients with PST and follow the course of the disease.Materials and MethodsIt is a study conducted in 23 patients (13 boys) with PST with/without central diabetes insipidus (CDI) diagnosed between 1990 and 2020 at Children’s Memorial Health Institute (CMHI) in Warsaw, Poland. We … Show more

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Cited by 11 publications
(7 citation statements)
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“…Finally, pituitary stalk is a funnel-shaped structure that connects the hypothalamus to the pituitary gland. There are several etiologies that give rise to PST ( 30 , 31 ), which often manifests clinically with CDI ( 32 , 33 ): autoimmunity/inflammation (neuroinfundibulohypophysitis ( 34 )) – sometimes referred as idiopathic PST, infectious diseases (e.g. tuberculosis ( 35 )) or neoplastic lesions ( 33 , 36 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Finally, pituitary stalk is a funnel-shaped structure that connects the hypothalamus to the pituitary gland. There are several etiologies that give rise to PST ( 30 , 31 ), which often manifests clinically with CDI ( 32 , 33 ): autoimmunity/inflammation (neuroinfundibulohypophysitis ( 34 )) – sometimes referred as idiopathic PST, infectious diseases (e.g. tuberculosis ( 35 )) or neoplastic lesions ( 33 , 36 ).…”
Section: Discussionmentioning
confidence: 99%
“…There are several etiologies that give rise to PST ( 30 , 31 ), which often manifests clinically with CDI ( 32 , 33 ): autoimmunity/inflammation (neuroinfundibulohypophysitis ( 34 )) – sometimes referred as idiopathic PST, infectious diseases (e.g. tuberculosis ( 35 )) or neoplastic lesions ( 33 , 36 ). Anti-pituitary, anti-hypothalamus autoantibodies or high IgG4 levels have been detected in some patients with hypophysitis.…”
Section: Discussionmentioning
confidence: 99%
“…The differential diagnosis on neuroimaging is not limited to other histiocytic disorders and also includes both tumoral entities, such as germ cell tumors, and autoimmune inflammatory conditions like lymphocytic hypophysitis ( 118 ).…”
Section: Sellar and Suprasellar Tumorsmentioning
confidence: 99%
“…Synchronous pineal and suprasellar tumors occur in 21% of cases [50][51]. GCT should be suspected in all children with PS thickening, especially with CDI [52]. Determining the underlying cause of CDI can be quite a challenge sometimes.…”
Section: Identi Cation Of the Underlying Cause Of CDImentioning
confidence: 99%