Pituitary tumor-transforming gene 1: Perspective on an apoptosis pathway

Zhao, Zhihong; Zhang, Mutian

doi:10.4161/cbt.11.3.14399

Cited by 1 publication

(1 citation statement)

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“…PTTG1 is a securin that regulates chromatid separation in the course of mitosis by inhibiting the activity of separase and maintaining sister chromatids together until the end of the metaphase [24]. During cell proliferation, Cdk-2 phosphorylates PTTG1 at Ser 165 .…”

Section: Biological Functions Of Pttg1mentioning

confidence: 99%

Pituitary Tumor-Transforming Gene 1/Delta like Non-Canonical Notch Ligand 1 Signaling in Chronic Liver Diseases

Perramón

Jiménez

2022

IJMS

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The management of chronic liver diseases (CLDs) remains a challenge, and identifying effective treatments is a major unmet medical need. In the current review we focus on the pituitary tumor transforming gene (PTTG1)/delta like non-canonical notch ligand 1 (DLK1) axis as a potential therapeutic target to attenuate the progression of these pathological conditions. PTTG1 is a proto-oncogene involved in proliferation and metabolism. PTTG1 expression has been related to inflammation, angiogenesis, and fibrogenesis in cancer and experimental fibrosis. On the other hand, DLK1 has been identified as one of the most abundantly expressed PTTG1 targets in adipose tissue and has shown to contribute to hepatic fibrosis by promoting the activation of hepatic stellate cells. Here, we extensively analyze the increasing amount of information pointing to the PTTG1/DLK1 signaling pathway as an important player in the regulation of these disturbances. These data prompted us to hypothesize that activation of the PTTG1/DLK1 axis is a key factor upregulating the tissue remodeling mechanisms characteristic of CLDs. Therefore, disruption of this signaling pathway could be useful in the therapeutic management of CLDs.

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Section: Biological Functions Of Pttg1mentioning

confidence: 99%