Pityriasis lichenoides: the differences between children and adults

Wahie, Shyamal; Hiscutt, E; Natarajan, S.; Taylor, Aileen

doi:10.1111/j.1365-2133.2007.08163.x

Cited by 69 publications

(105 citation statements)

References 17 publications

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“…4,5 Compared with adults, PL in children tends to be more widespread and run a more protracted course with lesions interspersed by periods of disease inactivity. 6 The histology of PL varies according to the clinical appearance of the biopsied lesion and the phase of lesion evolution. Both PLEVA and PLC lesions are characterized by a perivascular lymphocytic infiltrate with involvement of the epidermis, and the histologic differences between acute, subacute, and chronic lesions are related to the degree of associated vascular and epidermal damage.…”

Section: Introductionmentioning

confidence: 99%

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

Vonderheid¹,

Kadin²,

Gocke³

2011

The American Journal of Dermatopathology

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Pityriasis lichenoides (PL) and lymphomatoid papulosis (LyP) are uncommon idiopathic eruptions with overlapping clinical and histological features. Although current opinion indicates that PL and LyP are distinct and separate entities, molecular genetic evidence of T-cell clonality in both conditions suggests that an etiopathogenic relationship may exist. We report a patient who was diagnosed with LyP type B in 1985 followed by PL after 11 years. We hypothesize that LyP followed by PL in the same patient reflects differences in the host immune response to a common antigenic stimulus.

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Section: Introductionmentioning

confidence: 99%

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

Vonderheid¹,

Kadin²,

Gocke³

2011

The American Journal of Dermatopathology

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“…As each lesion evolve independently, lesions in all stages of progression are found next to each other predominantly on trunk and extremities in both PLEVA and PLC. [3][4][5][6][7] Here, we report an atypical presentation of PLC which was presented as plantar keratoderma.…”

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confidence: 99%

An Acral Pityriasis Lichenoides Chronica Case Presenting as Plantar Keratoderma

Allı¹,

Yorulmaz²,

Üstün³

2014

Turkiye Klinikleri J Dermatol

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“…3 Ho we ver, the da ta abo ut the res pon se to oral eryt hromy cin in the chil dren with PLE VA is con tro ver si al and the response ra tes va ri es bet we en 25-73%. 5 In many of the se ca ses, the rash re tur ned if the me dici ne was ta pe red to o ra pidly. Tet racy cli ne has been re por ted to be of va lu e as well.…”

mentioning

confidence: 99%

“…3 Alt ho ugh the conc lu si on was not con fir med by a sub se qu ent in ves tiga ti on, a smal ler study com pa ring adults and chil dren fo und that the di se a se ten ded to run a longer co ur se in chil dren, with gre a ter ex tent of le sions, mo re pig men ta ti on, and po or res pon se to con ven ti o nal tre at ment. 5 We re port a child with PLE VA un res pon si ve to eryt hromy cin, and ra pidly re sol ved with thre e co ur ses of azit hromy cin. The res pon se of our pa ti ent to azit hromy cin can be expla i ned by im pro ved syste mic ab sorp ti on, en han ced pe net ra ti on in to tis su es, and the lon ger half-li fe of azit hromy cin over eryt hromy cin.…”

mentioning

confidence: 99%

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Asymptomatic, Reddish Papules and Pustules with Hemorrhagic Crust on the Trunk of a Girl: Answer of the Last Issue’s Case Question

Arıcan¹,

Yalçin²

2011

Turkiye Klinikleri J Med Sci

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768ityriasis lichenoides et varioliformis acuta (PLEVA) is a cutaneous disorder of unknown etiology and characterized by a generalized eruption of acute onset, consisting of papular lesions that undergo central vesiculation which may ulcerate and resolve with hemorrhagic crusts.1,2 Although descriptions of this disorder had been made many times previously, term "PLEVA" was first described in 1925 by Habermann. 3 PLEVA occurs predominantly in the second or third decades of life and it is uncommon in childhood. There is a male predominance. 4 The disease starts on the trunk with erythematous papules that develop crusts, vesicles, pustules or erosions, then spontaneously regresses within a few weeks. 3,4Varioliform scars and postinflammatory hyper-or hypopigmentation may result.3 The eruption may be asymptomatic or sometimes accompanied by itching, fever and malaise. 1 There are three major pathogenic theories of PLEVA: an inflammatory reaction triggered by infectious agents; an inflammatory response secondary to a T-cell dyscrasia and an immune complex-mediated hypersensitivity vasculitis.3 A number of physicians suspect an infectious etiology such as Epstein-Barr virus, Toxoplasma gondii and Human immunodeficiency virus since the disease appears rapidly and favors younger patients.2,3 Several reports have demonstrated clonal T-cell receptor rearrangements from patient specimens, suggesting that PLEVA is a lymphoproliferative disorder involving T-cell subtypes, despite its clinically benign course and the absence of morphologically atypical cells in the skin lesions. 4 PLEVA is the prototypic disease featuring lymphocytic vasculitis, except that fibrin deposition is not seen. Lymphoid atypia is not a standard feature of PLEVA. All cases of PLEVA show interface dermatitis. There is exocytosis, parakeratosis and extravasation of erythrocytes. Epidermal damage range from intercellular and extracellular edema, to extensive keratinocyte necrosis, vesicles, pustules and ulcers. Immunohistochemical stainings are mostly positive for CD8 and negative for CD4 and CD30. A An na ah h t ta ar r K Ke e l li i m me e l le er r:

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Pityriasis lichenoides: the differences between children and adults

Abstract: This is the first study to compare PL in children and adults. Our findings suggest that, compared with adults, PL in children is more likely to run an unremitting course, with greater lesional distribution, more dyspigmentation and a poorer response to conventional treatment modalities.

Cited by 69 publications

References 17 publications

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

An Acral Pityriasis Lichenoides Chronica Case Presenting as Plantar Keratoderma

Asymptomatic, Reddish Papules and Pustules with Hemorrhagic Crust on the Trunk of a Girl: Answer of the Last Issue’s Case Question

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