2023
DOI: 10.33393/jcb.2023.2453
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PIVKA-II or AFP has better diagnostic properties for hepatocellular carcinoma diagnosis in high-risk patients

Abstract: Background: Hepatocellular carcinoma (HCC) is a lethal cancer. Two biomarkers were used for HCC diagnosis including alpha-fetoprotein (AFP) and protein induced by vitamin K absence-II or antagonist (PIVKA-II). However, data on biomarkers and HCC diagnosis are not consistent. This study aimed to evaluate if PIVKA-II, AFP, or a combination of both biomarkers had the best diagnostic properties for HCC. Methods: This was a prospective study and enrolled patients 18 years or over with a high risk for HCC. AFP and P… Show more

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“…HCC has significant cellular heterogeneity, which increases the likelihood of treatment resistance and hastens the rate of recurrence. However, some patients with AFP-negative HCC require novel tumour biomarkers because of tumour heterogeneity in order to predict their prognosis in clinical settings (Suttichaimongkol et al, 2023). According to a recent study, 50% of HCC patients are AFP negative, especially those with early-stage and tiny tumours.…”
Section: Introductionmentioning
confidence: 99%
“…HCC has significant cellular heterogeneity, which increases the likelihood of treatment resistance and hastens the rate of recurrence. However, some patients with AFP-negative HCC require novel tumour biomarkers because of tumour heterogeneity in order to predict their prognosis in clinical settings (Suttichaimongkol et al, 2023). According to a recent study, 50% of HCC patients are AFP negative, especially those with early-stage and tiny tumours.…”
Section: Introductionmentioning
confidence: 99%