Pivotal Research in Cardiovascular Syndromes in the Elderly:

McKay, Charles R.; Rich, Mike; Vlietstra, R. E.; Kitzman, Dalane W.; Fleg, Jerome L.; Krumholz, Harlan M.; Lakatta, Edward G.; Cooke, John P.; Cannon, Chris; Ezekowitz, M. D.; Frolich, E D; Jalife, José; Kass, David A.; Kottke, Bruce A.; Muller, James E.; Saltin, Bengt; Shen, Win Kuang; Somers, Virend

doi:10.1111/j.1076-7460.2000.89991.x

Cited by 7 publications

(5 citation statements)

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“…This is an issue of potential concern, given the published reports that cellular signaling in response to acute stress-in particular, the function and expression of G-protein-coupled receptors in the heart-is altered with increasing age [13,37,38]. A handful of studies have further identified as-yet poorly defined (and, in some instances, conflicting) age-associated alterations in the triggers, receptors and signaling pathways specifically implicated to play a role in PC-induced cardioprotection.…”

Section: Aging Adenosine and Adenosine-mediated Signalingmentioning

confidence: 99%

In Vitro Platelet Responsiveness to Adenosine-Mediated ‘Preconditioning’ is Age-Dependent

Przyklenk

Whittaker

2005

J Thromb Thrombolysis

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Section: Aging Adenosine and Adenosine-mediated Signalingmentioning

confidence: 99%

In Vitro Platelet Responsiveness to Adenosine-Mediated ‘Preconditioning’ is Age-Dependent

Przyklenk

Whittaker

2005

J Thromb Thrombolysis

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“…13,14 It is known that arterial function may have substantial regional variation. 15 In HFrEF, it has been shown that the increase in arterial stiffness is generalized and is observed in the peripheral arteries as well as the aorta, and has been shown to be modifiable with angiotensin receptor antagonism. 16 Moreover, the pulsatile components of arterial afterload are greater in HFpEF compared with HFrEF and may play a greater role in the pathophysiology of HFpEF than HFrEF.…”

Section: Introductionmentioning

confidence: 99%

Carotid Arterial Stiffness and Its Relationship to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction

et al. 2013

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Heart failure with a preserved ejection fraction (HFpEF) is the dominant form of heart failure in the older population. The primary chronic symptom in HFpEF is severe exercise intolerance, however, its pathophysiology and therapy are not well understood. We tested the hypothesis that older patients with HFpEF have increased arterial stiffness beyond that which occurs with normal aging and that this contributes to their severe exercise intolerance. Sixty-nine patients ≥ 60 years with HFpEF and 62 healthy volunteers (24 young healthy subjects ≤ 30 years (YHC) and 38 older healthy subjects ≥ 60 years old (OHC) were examined. Carotid arterial stiffness was assessed using high-resolution ultrasound and peak exercise oxygen consumption (VO2) was measured using expired gas analysis. Peak VO2 was severely reduced in the HFpEF patients compared to OHC (14.1±2.9 vs. 19.7±3.7 ml/kg/min; p<0.001) and in both was reduced compared to YHC subjects, (32.0±7.2 ml/kg/min; both p<0.001). In HFpEF compared to OHC, carotid arterial distensibility was reduced (0.97±0.45 vs. 1.33±0.55 × 10−3 mmHg−1, p=0.008) and Young’s elastic modulus (YEM) was increased (1320±884 vs. 925±530 kPa, p<0.02). Carotid arterial distensibility was directly (0.28; p=0.02) and YEM was inversely (−0.32; p=0.01) related with peak VO2. Carotid arterial distensibility is decreased in HFpEF beyond the changes due to normal aging and is related to peak VO2. This supports the hypothesis that increased arterial stiffness contributes to exercise intolerance in HFpEF and is a potential therapeutic target.

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“…The Pivotal Research in Cardiology in the Elderly (PRICE) conference series was established in 1999 as a mechanism for bringing together leading investigators and clinicians to review recent major advances in cardiovascular aging research and to identify specific research priorities for the years ahead. The first symposium addressed a broad range of topics relevant to cardiovascular disease in the elderly, while subsequent conferences focused on acute coronary syndromes, heart failure, and heart rhythm disturbances in older people 1–4 …”

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confidence: 99%

Fifth Pivotal Research in Cardiology in the Elderly (PRICE‐V) Symposium: Preventive Cardiology in the Elderly—Executive Summary. Part I: Morning Session

Rich

Mensah

2009

Preventive Cardiology

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Pivotal Research in Cardiovascular Syndromes in the Elderly:

Cited by 7 publications

References 0 publications

In Vitro Platelet Responsiveness to Adenosine-Mediated ‘Preconditioning’ is Age-Dependent

In Vitro Platelet Responsiveness to Adenosine-Mediated ‘Preconditioning’ is Age-Dependent

Carotid Arterial Stiffness and Its Relationship to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction

Fifth Pivotal Research in Cardiology in the Elderly (PRICE‐V) Symposium: Preventive Cardiology in the Elderly—Executive Summary. Part I: Morning Session

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