Pivotal role of separation chemistry in the development of radionuclide generators to meet clinical demands

A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb

“…The success of radionuclide generators depends on the selection of the parent/daughter pair and the radiochemical separation procedures. Dash et al summarized the selection criteria for the radiochemical separation method for radionuclide generators [122]. Radiochemical separation method should be fast, reproducible and provide the daughter radionuclide in high radionuclidic, radiochemical and chemical purity.…”

An overview of radioisotope separation technologies for development of 188W/188Re radionuclide generators providing 188Re to meet future research and clinical demands

“…Overviews of the principles regarding radioactive equilibria, in-growth and equilibrium of the daughter radionuclide with parent radionuclide, have been elaborately discussed in detail in recent reviews. [40][41][42] In-growth of the 188 Re in 188 W/ 188 Re generator is continuous, and once the 188 Re activity of the daughter is recovered from the 188 W/ 188 Re equilibrium mixture, 188 Re activity increases until its activity level reaches a maximum and is in equilibrium with 188 W activity as depicted in the Fig. 4.…”

Mechanochemically synthesized mesoporous alumina: a smart new-generation sorbent for preparation of chromatographic 188W/188Re generator

“…Efficiency, reliability, safety and cost-effectiveness are the key parameters that govern the development of next-generation radionuclide generators for regular usage in clinical context. To a large extent, progress in design of improved radionuclide generators is dependent on the advancements in separation science and technology [1]. Owing to its simplicity and convenience to use in hospital radiopharmacies, the column chromatographic separation technique has found the widest application in development of radionuclide generators.…”