2024
DOI: 10.21203/rs.3.rs-4618560/v1
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PIWIL1 is recruited to Centrosomes during Mitosis in Colorectal Cancer Cells and is linked to cell cycle progression

Maria Rosa Garcia-Silva,
Sofía Montenegro,
Sofía Dacosta
et al.

Abstract: Background PIWI proteins, traditionally associated with germline development, have recently gained attention for their expression in various cancers, including colorectal cancer. However, the molecular mechanisms underlying their reactivation and impact on cancer initiation and progression remain elusive.Results Here, we found that PIWIL1 is expressed at relatively high levels in CRC-derived samples and cell lines, where it undergoes a dynamic re-localization to the centrosome during mitosis. Knockdown of PIWI… Show more

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