Pixelized Measurement of 99mTc-HDP Micro Particles Formed in Gamma Correction Phantom Pinhole Scan: a Reference Study

Jung, Joo Young; Cheon, Gi Jeong; Lee, Yun Sang; Ha, S. W.; Chae, Mi Hye; Chung, Yong An; Yoon, Do Kyun; Bahk, Yong‐Whee

doi:10.1007/s13139-015-0391-8

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…Interpolation between the bins was achieved using the Gaussian curve fitting method with in-house MATLAB code (Mathworks, R2011a, Natick, MA, USA). 5,6 The following equation was used for Gaussian curve fitting: Where y = interpolated value, x = original frame value, x0 = mean value of the frame value, and σ = standard deviation.…”

Section: Methodsmentioning

confidence: 99%

“…The size of the individual TMF based on unsuppressed 99m Tc-HDP uptake was calculated using the pixelized method. 5 Each micro-spot was appointed as a region of interest. The image profile was presented as a line spread function denoting the signal intensity of the applied line, with the y-axis indicating the signal intensity and the x-axis indicating the pixel number.…”

Section: Methodsmentioning

confidence: 99%

“…Interpolation between the bins was achieved using the Gaussian curve fitting method with inhouse MATLAB code (Mathworks, R2011a, Natick, MA, USA). 5,6 The following equation was used for Gaussian curve fitting:…”

Section: Measurement Of Tmf Size Based On Unsuppressed 99m Tc-hdp Uptakementioning

confidence: 99%

“…3 Furthermore, NIH ImageJ densitometry has proven useful for the differential quantitation of 99m Tc-HDP uptake among BME, BMH, and TMF, 4 while pixelized measurement has been used to measure the precise size of TMF. 5 We propose that the integrated use of sequential nPBS and GCPBS, together with NIH ImageJ densitometry and pixel measurement, collectively termed visuospatial-mathematic assay (VSMA), could help to differentiate among BME, BMF, and TMF.…”

Section: Introductionmentioning

confidence: 99%

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Precise differential diagnosis of acute bone marrow edema and hemorrhage and trabecular microfractures using naïve and gamma correction pinhole bone scans

et al. 2019

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Objective To analyze the performance of sequential naïve pinhole bone scan (nPBS) and gamma correction pinhole bone scan (GCPBS), reinforced by ImageJ densitometry and pixelized microfracture measurement, for making specific diagnoses of bone marrow edema (BME), bone marrow hemorrhage (BMH), and trabecular microfractures (TMF). Methods We prospectively examined BME, BMH, TMF, and normal trabeculae in 10 patients using sequential nPBS and GCPBS. The intensity of 99mtechnetium-hydroxydiphosphonate (99mTc-HDP) uptake was measured using a pixelized method and calculated using ImageJ densitometry in terms of arbitrary units (AU). This overall method was termed a visuospatial-mathematic assay (VSMA). We analyzed the ability of the calculated AU values to discriminate between the four states using GraphPad Prism software, with reference to previous morphological data. Results The calculated values were categorized as ≤50 AU for normal trabecula, 51–100 AU for BME, 101–150 AU for BMH, and ≥151 AU for TMF. The difference in uptake between normal trabecula and BME was significant and the differences among BME, BMH, and TMF were highly significant. Conclusion VSMA is a useful technique for refining objective individual diagnoses and for differentiating and quantitating BME, BMH, and TMF.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Measurement Of Tmf Size Based On Unsuppressed 99m Tc-hdp Uptakementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Precise differential diagnosis of acute bone marrow edema and hemorrhage and trabecular microfractures using naïve and gamma correction pinhole bone scans

et al. 2019

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“…The size of individual micro Tc-99m HDP uptake was mathematically calculated using the pixelized measurement method. [ 20 – 22 ] Each micro-spot was appointed as a region of interest. The image profile is presented in a line spread function denoting the signal intensity of the applied line.…”

Section: Methodsmentioning

confidence: 99%

Morphobiochemical diagnosis of acute trabecular microfractures using gamma correction Tc-99m HDP pinhole bone scan with histopathological verification

Bahk¹,

Hwang²,

Lee³

et al. 2017

Medicine

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Gamma Correction 99mTc-HDP Pinhole Scan Diagnosis of Trabecular Microfracture and Contusion

Bahk¹,

Chung

2017

Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases

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Pixelized Measurement of 99mTc-HDP Micro Particles Formed in Gamma Correction Phantom Pinhole Scan: a Reference Study

Abstract: This method can be used for precise quantitative and qualitative diagnosis of bone and joint diseases at the trabecular level.

Cited by 13 publications

References 7 publications

Precise differential diagnosis of acute bone marrow edema and hemorrhage and trabecular microfractures using naïve and gamma correction pinhole bone scans

Precise differential diagnosis of acute bone marrow edema and hemorrhage and trabecular microfractures using naïve and gamma correction pinhole bone scans

Morphobiochemical diagnosis of acute trabecular microfractures using gamma correction Tc-99m HDP pinhole bone scan with histopathological verification

Gamma Correction 99mTc-HDP Pinhole Scan Diagnosis of Trabecular Microfracture and Contusion

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