PKC-induced stiffening of hyaluronan/CD44 linkage; local force measurements on glioma cells

Lamontagne, Charles-Antoine; Grandbois, Michel

doi:10.1016/j.yexcr.2007.07.013

Cited by 27 publications

(18 citation statements)

References 50 publications

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“…Once CD44 interacted with hyaluronan (HA), as an important ligand of CD44, the cytoplasmic tail of CD44 binded to the actin cytoskeleton and induced CD44 movement toward the leading edge of the migrating cells. Thereafter CD44 could bind to CD62 on endothelial cells, resulting in the migrating cells rolling on the endothelial cells as the initial step of the extravasation (Lamontagne and Grandbois 2008;Fehon et al 2010;Zoller 2011). The HA-CD44 interaction could also activate the ROK pathway, which resulted the phosphorylation of the Na+/H+ exchange (Bourguignon et al 2004) and facilitated extracellular matrix degradation and tumor invasion.…”

Section: Discussionmentioning

confidence: 99%

CD44 Expression Is Predictive of Poor Prognosis in Pharyngolaryngeal Cancer: Systematic Review and Meta-Analysis

Chai

Liu

Wang

et al. 2014

Tohoku J. Exp. Med.

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Pharyngolaryngeal cancer is one of the most common head and neck cancer worldwide, and the early diagnosis and prognosis prediction are still difficult because of lacking in reliable cell markers. Although the expression of CD44 has been reported to correlate with poor prognosis of pharyngolaryngeal cancer in most literatures, some controversies still exist. Since the limited patient numbers within independent studies, here we performed a meta-analysis to clarify the correlations between CD44 expression and clinicopathological features and prognosis in pharyngolaryngeal cancer. A search of PubMed, ISI Web of Science and China National Knowledge Infrastructure databases (up to June 2013) was performed. Nineteen studies with 1,405 patients met the inclusion criteria. The expression of pan-CD44, including all variant isoforms, was detected in 58.0% (14.1-79.2%) specimens, while CD44-v6 (variant isoform 6 of CD44) was expressed in 54.8% (12-79.2%). In pooled analysis, CD44 expression was significantly associated with larger tumor size (T category, RR (relative risk) = 1.21, 95% CI: 1.01-1.46), lymph nodes metastasis (N category, RR = 1.94, 95% CI: 1.38-2.73) and poor prognosis [3-year overall survival (OS): RR = 0.70, 95% CI: 0.53-0.91; 5-year OS: RR = 0.66, 95% CI: 0.66-0.94]. In the stratified analysis of CD44 isoforms, high expression of CD44-v6 was related with a poor 5-year OS rate (RR = 0.53, 95% CI: 0.37-077). We propose that CD44 expression is associated with tumor size, lymph node metastasis, and poor prognosis in pharyngolaryngeal cancer patients.

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Section: Discussionmentioning

confidence: 99%

CD44 Expression Is Predictive of Poor Prognosis in Pharyngolaryngeal Cancer: Systematic Review and Meta-Analysis

Chai

Liu

Wang

et al. 2014

Tohoku J. Exp. Med.

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“…By HA binding, the CD44 conformation becomes altered such that its cytoplasmic tail interacts with the cytoskeleton via ankyrin (11) and ERM (Ezrin/Radixin/Moesin) proteins (12), which guide CD44 to the leading edge of migrating cells (13). The CD44-HA interaction also stimulates MMP2 and MMP9 production (14) and promotes MMP9 binding to CD44, which supports invasiveness by focalized matrix degradation (14).…”

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confidence: 99%

CD44v6 Coordinates Tumor Matrix-triggered Motility and Apoptosis Resistance

Jung¹,

Groß

Zöller

2011

Journal of Biological Chemistry

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Tumor progression requires a crosstalk with the tumor surrounding, where the tumor matrix plays an essential role. We recently reported that only the matrix delivered by a CD44v6-competent (ASML wt ), but not that of a CD44v6-deficient (ASML-CD44v kd ) rat pancreatic adenocarcinoma line supports metastasis formation. We here describe that this matrix provides an important feedback toward the tumor cell and that CD44v6 accounts for orchestrating signals received from the matrix. ASML wt cells contain more hyaluronan synthase-3 and secrete higher amounts of >50 kDa HA than ASML-CD44v kd cells, which secrete more hyaluronidase. Only the ASML wt -matrix supports migration and apoptosis resistance, which both can be initiated via CD44v6, c-Met, and ␣6␤4 ligand binding and proceed via FAK, PI3K/Akt, and MAPK activation, respectively. However, c-Met-and ␣6␤4-initiated signaling are strongly augmented by the association with CD44v6 as only very weak effects are observed in CD44v6-deficient cells. The same CD44v6-dependent convergence of motility-and apoptosis resistance-related signals also accounts for human tumor lines. Thus, CD44v6 promotes motility and apoptosis resistance via its involvement in assembling a matrix that, in turn, triggers activation of signaling cascades, which proceeds, independent of the initiating receptor-ligand interaction, in a concerted action via CD44v6.

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“…HA binding promotes cell motility and migration, two paramount processes involved on tumour cells dissemination, extravasation of CSCs (Lamontagne and Grandbois, 2008), and metallo-proteases production (Baronas-Lowell et al, 2004).…”

Section: Colon Csc Markersmentioning

confidence: 99%

Colorectal cancer defeating? Challenge accepted!

Franco

Todaro

Dieli³

et al. 2014

Molecular Aspects of Medicine

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Colorectal tumours are actually considered as aberrant organs, within it is possible to notice a different stage of cell growth and differentiation. Their origin is reported to arise from a subpopulation of tumour cells endowed with, just like the healthy stem cells, self-renewal and aberrant multi-lineage differentiation capacity likely to be called colorectal cancer stem cells (CCSCs). Cancer stem cells (CSCs) fate, since their origin, reflects the influences from their microenvironment (or niche) both in the maintenance of stemness, in promoting their differentiation, and in inducing epithelial-mesenchymal transition, responsible of CSCs dissemination and subsequent formation of metastatic lesions. The tumour cells heterogeneity and their immuno-response resistance nowadays probably responsible of the failure of the conventional therapies, make this research field an open issue. Even more importantly, our increasing understanding of the cellular and molecular mechanisms that regulate CSC quiescence and cell cycle regulation, self-renewal, chemotaxis and resistance to cytotoxic agents, is expected to eventually result in tailor-made therapies with a significant impact on the morbidity and overall survival of colorectal cancer patients

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PKC-induced stiffening of hyaluronan/CD44 linkage; local force measurements on glioma cells

Cited by 27 publications

References 50 publications

CD44 Expression Is Predictive of Poor Prognosis in Pharyngolaryngeal Cancer: Systematic Review and Meta-Analysis

CD44 Expression Is Predictive of Poor Prognosis in Pharyngolaryngeal Cancer: Systematic Review and Meta-Analysis

CD44v6 Coordinates Tumor Matrix-triggered Motility and Apoptosis Resistance

Colorectal cancer defeating? Challenge accepted!

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