PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

Wu, Yun; Wang, Han; Qiu, Ying-Kun; Loh, Xian Jun

doi:10.1039/c6ra08022g

Cited by 66 publications

(47 citation statements)

References 54 publications

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“…Recent advancement in this area is mostly focusing on minima invasive cancer therapy and bioimaging. Our group has been developing thermogelling polyurethanes based on PEG and PPG, with the third hydrophobic component being either poly(L‐lactide) (PLLA), poly([R]‐hydroxybutyrate)(PHB), or poly[(R)‐3‐hydroxybutyrate‐co‐4‐hydroxybutyrate] (P3HB4HB), each with varying degrees of hydrophobicity. Since hydrolysis is the fundamental mechanism for degradation, consequently by changing the third group it is possible to change the duration of time required for biodegradation.…”

Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

“…Biodegradation is important to ensure that the polymer can naturally degrade over time and does not persist within the body. Thermogels with PLLA and PHB were used as drug delivery depot for treating cancerous animal models ,. These drug‐loaded thermogels could effectively inhibit the growth of cancer cells.…”

Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

“…Hydrogels have a high water content, mild processing conditions, and are able to control the release of large macromolecules . Strong interest in hydrogels has developed due to their biocompatibility properties, and it is also possible to modulate the mechanical strength of hydrogels to match biological tissues …”

Section: Introductionmentioning

confidence: 99%

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A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

Ke-min

Liow

Karim

et al. 2018

The Chemical Record

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Chemically crosslinked covalent hydrogels form a permanent and often strong network, and have been extensively used so far in drug delivery and tissue engineering. However, it is more difficult to induce dynamic and highly tunable changes in these hydrogels. Noncovalently formed hydrogels show promise as inherently reversible systems with an ability to change in response to dynamic environments, and have garnered strong interest recently. In this Personal Account, we elucidate a few key attractive properties of noncovalent hydrogels and describe recent developments in hydrogels crosslinked using various different noncovalent interactions. These hydrogels offer huge control for modulating material properties and could be more relevant mimics for biological systems.

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Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

Section: Types Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

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A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

Ke-min

Liow

Karim

et al. 2018

The Chemical Record

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“…From the environmental standpoint, it is also useful to develop biodegradable antibacterial polymers. With regards to biodegradable antibacterial compounds, there is also potential to use polyesters such as poly[(R)-3-hydroxybutyrate], [74][75][76][77][78][79][80][81][82][83] poly(lactic acid), 84,85 poly(e-caprolactone) [86][87][88] or even polycarbonates. 89,90 These polyesters have been extensively used for the development of biomaterials and future work can focus on these polymer backbones and their subsequent modi¯cations.…”

Section: Outlook and Perspectivesmentioning

confidence: 99%

Latest Advances in Antibacterial Materials

Loh

2017

J. Mol. Eng. Mater.

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This paper will update readers on the latest work in the area of antibacterial polymeric systems. There is extensive literature on existing systems. This complexity con¯nes us to the latest antibacterial materials which possess (1) responsive antibacterial activity on their own; (2) antibio¯lm formation and (3) formation of antibacterial polymeric¯lms. The objective of this review is to provide an overview of the antibacterial synthetic polymer¯eld. In this paper, I will analyze the early promise of this technology as well as highlight potential challenges that adopters could face. The primary focus will be the application of materials to the medical industry and to show how these materials can be tailored to create responsive, customized bactericidal materials.

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“…Liposomes have also been used as carriers for the targeted delivery of paclitaxel to the cancer cells . Thermogels are potentially useful for a variety of biomedical applications . In the area of tissue engineering, the encapsulation and differentiation of stem cells were shown by Jeong's group .…”

Section: Introductionmentioning

confidence: 99%

PHB‐Based Gels as Delivery Agents of Chemotherapeutics for the Effective Shrinkage of Tumors

Wang

Qiu

et al. 2016

Adv Healthcare Materials

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106

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Injectable thermogel to deliver chemotherapeutics in a minimally invasive manner and to achieve their long term sustained release at tumor sites to minimize side effects is attractive for chemotherapy and precision medicine, but its rational design remains a challenge. In this work, a copolymer with natural biodegradable poly[(R)-3-hydroxybutyrate] (PHB), hydrophilic poly(ethylene glycol), and temperature sensitive poly(propylene glycol) blocks linked by urethane linkages is designed to show thermogelling characteristics which are beneficial for minimally invasive injection and safe degradation. This thermogelling polymer possesses in vitro biocompatibility with very low cyto-toxicity in HEK293 cells. Furthermore, it is able to form the gel to achieve the controllable release of paclitaxel (PTX) and doxorubicin (DOX) by adjusting polymer concentrations. A rodent model of hepatocarcinoma has been performed to demonstrate the in vivo applications of this PHB-based thermogel. The drug-loaded thermogel has been intratumorally injected and both PTX-loaded and DOX-loaded thermogel have significantly slowed down tumor growth. This work represents the first time that injectable PHB thermogels have possessed good controllable release effect of chemotherapeutics against the in vivo model of tumors and will benefit various applications, including on-demand drug delivery and personalized medicine.

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PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

Abstract: This work represents the first time that poly(PEG/PPG/PLA urethane) has been used for the delivery of drugs to tumours in vivo and the encouraging results point to the potential for further development of this thermogel platform for anti-cancer applications.

Cited by 66 publications

References 54 publications

A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

Latest Advances in Antibacterial Materials

PHB‐Based Gels as Delivery Agents of Chemotherapeutics for the Effective Shrinkage of Tumors

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