Place of Igra Tests (Tests for Interferon-Gamma Determination) in Tuberculosis Infection Diagnosis

Russkikh, O. E.; Kudlаy, D.А.

doi:10.24110/0031-403x-2020-99-6-231-235

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Проблема диагностики особенно затруднена на стадии выраженного иммунодефицита при ограниченных и диссеминированных формах туберкулеза [8]. Перспективными являются лабораторные тесты, действие которых основано на оценке высвобождения интерферона-гамма (ИФН-γ) мононуклеарными клетками крови в результате их взаимодействия со специфическими белками M. tuberculosis (ESAT-6 и CFP-10) [4,7].…”

Section: Rezumat Posibilități Moderne De Diagnosticare a Tuberculozei La Pacienții Cu Infecție Hivunclassified

Modern possibilities of diagnostics of tuberculosis in patients with HIV infection

Kuznetsova¹,

Borodulina²

2021

BulMed

View full text Add to dashboard Cite

The problem of the steady growth of HIV-associated tuberculosis has become increasingly urgent in recent years in Russia. Diagnosis of tuberculosis is particularly difficult at the stage of severe immunodeficiency. Objective. to evaluate the effectiveness of the T-SPOT ® method.TB in the diagnosis of tuberculosis infection in patients with HIV infection. Materials and methods. in the period for 2019-2020, the T-SPOT®.TB results were analyzed in 396 patients. The criteria for inclusion in this study were the age of 18 years and older, the diagnosis of HIV infection, follow-up at the AIDS center. Results. in the group with a positive T-SPOT®.TB and changes on the computed tomogram, the verified diagnosis of tuberculosis was 90.7% of the group with both signs and 75.5% of those with a positive result T-SPOT®.TB. The group with a positive result T-SPOT®.TB and no changes on the CT scan is 16.8% of those with a positive result T-SPOT®.TB,such patients were diagnosed with „latent tuberculosis infection”. Conclusion. T-SPOT®.TB can be used in the diagnostic complex of monitoring patients with HIV infections — as a screening method that allows not only to verify the diagnosis, but also to detect latent tuberculosis.

show abstract

Section: Rezumat Posibilități Moderne De Diagnosticare a Tuberculozei La Pacienții Cu Infecție Hivunclassified

Modern possibilities of diagnostics of tuberculosis in patients with HIV infection

Kuznetsova¹,

Borodulina²

2021

BulMed

View full text Add to dashboard Cite

show abstract

Skin test based on <i>Mycobacterium tuberculosis</i> antigens (ESAT-6 and CFP-10) for the detection of tuberculosis infection in world practice

Russkikh

Savintseva

Kudlay

et al. 2023

Pulʹmonologiâ (Mosk.)

View full text Add to dashboard Cite

According to experts, 2 billion people in the world are infected with the causative agent of tuberculosis. A priority task in the diagnosis of tuberculosis infection is the use of accurate, accessible and scalable tools. The tuberculin skin test (TST), or Mantoux test, and the interferon gamma release assay (IGRA) are currently used to diagnose tuberculosis infection. In 2022, the World Health Organization (WHO) identified a fundamentally new class of skin tests for the early detection of tuberculosis infection, the so-called Mycobacterium tuberculosis antigen-based skin tests (TBST). These tests include Diaskintest (Russia), C-Tb (India), and C-TST (China) and pose an alternative to the tuberculin skin test and the IGRA. The aim of this work was to conduct a systematic review of domestic and foreign literature sources on the use of a new skin test based on M. tuberculosis antigens (ESAT-6 and CFP-10) to detect tuberculosis infection (Diaskintest) in world practice. Conclusion. According to the literature data, including the published results of meta-analyzes on the use of skin tests, it has been shown that recombinant tuberculous allergen test, as a new skin test based on M. tuberculosis antigens (ESAT-6 and CFP-10), or TBST, has high sensitivity and specificity for the detection of tuberculosis infection. Its sensitivity and specificity are significantly higher than those of the tuberculin test. TBST skin test results are comparable to those of IGRA, have a favorable safety profile, combined with high laboratory test specificity and ease of performance and assessment of the result in one cut (cut-off > 0 mm – any size papule is considered positive). Thus, TBST is a valuable tool for early detection of TB infection. Taking into account the volume of scientific clinical studies on recombinant tuberculous allergen test in the world practice, more than 10 years of experience in clinical practice in Russia and the CIS countries, it can be concluded that recombinant tuberculous allergen test is currently the leading test for mass diagnosis of tuberculosis infection not only in Russia, but also in the world.

show abstract

Assessment of specificity of immunologic tests for detection of tuberculosis infection in children with juvenile idiopathic arthritis

Aksenova,

Dementyeva,

Kazakov

et al. 2024

Medicinskij sovet

Self Cite

View full text Add to dashboard Cite

Introduction. The use of genetic engineering biological agents (GEBA) in the treatment of rheumatic diseases over the past decades has led to a significant improvement in the prognosis in this group of patients. However, against the background of anti-tumor necrosis factor α therapy (anti TNF-α), the risk of developing tuberculosis increases tenfold.Aim. To evaluate the specificity and safety of Mantoux test, recombinant tuberculosis allergen (RTA) test, IGRA tests: TB-Feron IGRA, T-SPOT.TB, QuantiFERON-TB GIT in patients from 5 to 18 years of age, who are at risk for the development of tuberculosis, due to the use of immunosuppressive therapy, including GEBP.Materials and methods. This clinical trial is a prospective single-center open-label study with 120 patients under observation. Girls predominated among the patients – 71 (59.2%), the average age was 12 years (95% CI [5.2–17.4]). As part of the treatment of the underlying disease, patients in the vast majority of cases (78.3%) received iFNO-α drugs: etanercept (67 people), adalimumab (25 people), golimumab (2 people).Results and discussion. According to the results of a comprehensive medical examination, including CT scan of the chest organs, the presence of active tuberculosis was not established in any of the patients. A positive result of the RTA sample was registered in 0.8% of the subjects, Mantoux test in 46.6%, T-SPOT.TB – 1.7%, TB-Feron IGRA and QuantiFERON-TB GIT – 0.8% each. During the safety assessment, it was noted that within 28 days after the study, none of the 120 patients had any adverse events. Patients need appropriate screening before starting treatment and regular follow-up examinations.Conclusions. The Mantoux test with 2 TE has low specificity (0.49), and the sample with RTA (0.99), TB-Feron IGRA (0.99), T-SPOT.TB (0.98) and QuantiFERON-TB GIT (0.99) are highly specific and safe as tests for detecting tuberculosis infection in children with juvenile idiopathic arthritis.

show abstract

Place of Igra Tests (Tests for Interferon-Gamma Determination) in Tuberculosis Infection Diagnosis

Cited by 4 publications

References 0 publications

Modern possibilities of diagnostics of tuberculosis in patients with HIV infection

Modern possibilities of diagnostics of tuberculosis in patients with HIV infection

Skin test based on <i>Mycobacterium tuberculosis</i> antigens (ESAT-6 and CFP-10) for the detection of tuberculosis infection in world practice

Assessment of specificity of immunologic tests for detection of tuberculosis infection in children with juvenile idiopathic arthritis

Contact Info

Product

Resources

About