Placebo‐controlled oral challenge with cobalt in patients with positive patch tests to cobalt

Veien, Niels K.; Hattel, Thais; Laurberg, Grete

doi:10.1111/j.1600-0536.1995.tb00453.x

Cited by 48 publications

(36 citation statements)

References 9 publications

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“…Recently, it has been documented that avoidance of prolonged skin contact with nickel-releasing alloys results in a statistically significant decrease in the frequency of hand eczema in nickel-sensitive individuals [24] . The study of orally provoked fiare-ups of nickel dermatitis was pioneered by Christensen and Moller [9], followed up by Kaaber et al [25,26] and Veien et al [27]. In a double-blind study, Christensen and Moller provoked 12 nickel-sensitive individuals with an oral dose of 5.6 mg nickel.…”

Section: Nickelmentioning

confidence: 98%

Systemic Contact Dermatitis

Menné¹,

Veien²

2001

Textbook of Contact Dermatitis

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Section: Nickelmentioning

confidence: 98%

Systemic Contact Dermatitis

Menné¹,

Veien²

2001

Textbook of Contact Dermatitis

Self Cite

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“…It should also be noted that on the other hand, experimental studies have also shown that repeated oral exposure to Ni may prevent diminish sensitization. Sjövall et al (1987), Santucci et al (1988), and Bonamonte et al (2011) (Christensen and Möller., 1975;Kaaber et al, 1978Kaaber et al, , 1979Jordan and King;Veien and Kaaber, 1979;Cronin et al, 1980;Burrows et al, 1981;Bedello et al, 1985;Sertoli et al, 1985;Gawkrodger et al, 1986;Roduner et al, 1987;Veien et al, 1987;Santucci et al, 1988;Möller et al, 1999;Nielsen et al, 1999;Hindsén et al, 2001;Jensen et al, 2003). There appeared a clear indication of increasing reaction rate associated with increasing dose.…”

Section: Sensitizationmentioning

confidence: 99%

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Publication¹

2015

EFS2

119

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EFSA received a request from the Hellenic Food Authority (EFET) for a scientific opinion on the risk to human health from the presence of nickel (Ni) in food, particularly in vegetables. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) decided to extend the risk assessment also to drinking water. The reproductive and developmental toxicity in experimental animals was selected as the critical effect for the assessment of chronic effects of Ni. A tolerable daily intake of 2.8 µg Ni/kg body weight (b.w.) per day was derived from a lower 95 % confidence limit for a benchmark dose at 10 % extra risk (BMDL 10 ) of 0.28 mg/kg b.w. for post-implantation fetal loss in rats. The current dietary exposure to Ni raises concern when considering the mean and 95th percentile chronic exposure levels for all different age groups. The systemic contact dermatitis (SCD) elicited in Ni-sensitive humans after oral exposure to Ni was selected as the critical effect suitable for the assessment of acute effects of Ni. A lowest BMDL 10 of 1.1 µg Ni/kg b.w. was derived for the incidence of SCD following oral exposure to Ni of human volunteers. The CONTAM Panel applied a margin of exposure (MOE) approach and considered an MOE of 10 to be indicative of a low health concern. The MOEs calculated considering the estimated mean and the 95th percentile acute exposure levels were considerably below 10 for all age groups. Overall, the CONTAM Panel concluded that, at the current levels of acute dietary exposure to Ni, there is a concern that Ni-sensitized individuals may develop eczematous flare-up skin reactions. The CONTAM Panel noted the need for mechanistic studies to assess the human relevance of the effects on reproduction and development observed in experimental animals and for additional studies on human absorption of nickel from food, for example in combination with duplicate diet studies. Following a call for data on Ni levels in food and drinking water (water intended for human consumption and mineral waters), a total of 18 885 food samples and 25 700 drinking water samples were available in the final dataset to estimate dietary exposure to nickel. No speciation data were provided. Samples were collected between 2003 and 2012 in 15 different European countries, with almost 80 % of the total collected in one Member State. The most reported analytical methods were inductively coupled plasma-mass spectrometry (ICP-MS) and atomic absorption spectrometry (AAS), that represented 54 % and 42 % of the methods reported, respectively. The highest sensitivity was reported for the analysis of drinking water with a limit of quantification (LOQ) of 0.001 µg/L (for both ICP-MS and AAS). In food, ICP-MS showed the lowest LOQ for the analysis of 'Alcoholic beverages' (0.002 µg/kg) while the lowest LOQ reported with AAS was 1 µg/kg for samples of 'Fish and seafood' and 'Sugar and confectionery'. In the final dataset, left-censored data represented 66 % of the analytical results, with 35 % in food samples and 89 % in drinking water sa...

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“…When the correlation between nickel allergy and systemic disorders was demonstrated, specific elimination diets were developed to reduce the daily nickel-intake, with significant improvement of symptoms in most patients (23). The etiopathogenetic role of nickel in the genesis of systemic disorders is confirmed by the relapse of previous contact lesions (24)(25)(26), appearance of widespread eczematous (14,27) and urticaria-like general lesions (12,19,28) after oral nickel challenge test. A complete nickel avoidance is extremely difficult and, if prolonged, may have nutritional consequences (29)(30), thus calling for the development of new therapeutic strategies.…”

mentioning

confidence: 99%

A Clinical Trial of Oral Hyposensitization in Systemic Allergy to Nickel

Schiavino

Nucera

Alonzi

et al. 2006

Int J Immunopathol Pharmacol

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Nickel allergy is the most common contact allergy. Some nickel-sensitive patients present systemic (cutaneous and/or digestive) symptoms related to the ingestion of high nickel-content foods, which significantly improve after a specific low nickel-content diet. The etiopathogenetic role of nickel in the genesis of systemic disorders is, furthermore, demonstrated by the relapse of previous contact lesions, appearance of widespread eczema and generalized urticaria-like lesions after oral nickel challenge test. The aim of this study is to investigate the safety and efficacy of a specific oral hyposensitization to nickel in patients with both local contact disorders and systemic symptoms after the ingestion of nickelcontaining foods. Inclusion criteria for the recruitment of these patients were (other than a positive patch test) a benefit higher than 80% from a low nickel-content diet and a positive oral challenge with nickel. Based on the previous experiences, our group adopted a therapeutic protocol by using increasing oral doses of nickel sulfate associated to an elimination diet. Results have been excellent: this treatment has been effective in inducing clinical tolerance to nickel-containing foods, with a low incidence of side effects (gastric pyrosis, itching erythema).Nickel allergy is the most common contact allergy because nickel is present in various dailyuse accessories and utensils (coins, pots and pans, watches, earrings, etc.) and its widespread use favors sensitization (I). The prevalence of nickel allergy has shown a constant rise in industrialized countries, about 10-15% (with peaks up to 20%) in females, and 4-7% in males (2-4). Female predominance is probably due to a more frequent exposure to metal jewellery and to the higher incidence of allergic diseases in women.Nickel allergy is a delayed, cell-mediated hypersensitivity, presenting with local eczematous lesions after skin contact with nickel and it can be diagnosed by patch tests. Some reports in literature describe how the use of dental and orthopedic prostheses may provoke generalized eczema (5-6) and urticaria (7-8) in nickel-allergic patients.Nickel is an essential element in the diet: its daily intake is about 300 ug, and vegetables are the main source (9-11). Some cases have been described of nickel-sensitized patients with cutaneous systemic disorders correlated to the ingestion of high nickel-content foods: generalized eczema (12-13), recurrent vesicular hand eczema (pompholyx) (14-15), itching erythema with mild

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Placebo‐controlled oral challenge with cobalt in patients with positive patch tests to cobalt

Cited by 48 publications

References 9 publications

Systemic Contact Dermatitis

Systemic Contact Dermatitis

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

A Clinical Trial of Oral Hyposensitization in Systemic Allergy to Nickel

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