Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children With Chronic Respiratory Problems: Iii. Clinical Findings

Abstract

The role of glucan in stimulation of immune reactions has been studied for decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems. We measured the physical endurance using a 6MWT test and the levels of eNO in 50 children aged 8-12 years and evaluated the effects of 100 mg/d oral dose of glucan. We found significant improvements in physical indurance and exhaled nitric oxide in glucan-treated children. In addition, strong improvements in general conditions were found. Short-term oral application of natural immunomodulator β-glucan enhancers the overall health and regulation of energetic metabolism in children with chronic respiratory problems.

Effects of Dietary Nucleotides on Immune Mechanisms and Physical State in Children with Chronic Respiratory Problems

“…20% of the original level). It was found that the climatotherapy treatment together with speleotherapy, higher physical activity and improved nutrition resulted in significant medical improvements (Vetvicka et al, 2013a;2013b;2013c;Ostojic et al, 2013). As confirmed by other authors (Schuh, 1993), we showed that this improved regime leads to significant improvements of immune functions, lowering of the risk of infections and improvements in the state of current diseases such as respiratory problems or asthma bronchiale (Buka et al, 2006;Davis et al, 2004).…”

“…Nutritional intervention in the form of food supplementation, with nucleotides, micronutrients, bovine colostrum or glucans, in groups with increased physical challenge have become the main research approach of numerous laboratories (Ostojic et al, 2013;Davis et al, 2004;Gunzer et al, 2012;Ostojic and Obrenovic, 2012;Riera et al, 2013;Stier et al, 2014;Wolvers et al, 2006). It is the results of our quest for an increase of immune reactions not only in athletes, but also in clinical medicine (Ciacio et al, 2014) and in possible renovation of damaged mucosal immunity in children exposed to effects of environmental contaminants (Richter et al, 2014;Vetvicka et al, 2013a;2013b;2013c). Based on these trials, several commercial supplements appeared on the market, including Oral Impal from Nestle (Ciacio et al, 2014; Sublingual nucleotides, extract from germinated barley (Ostojic and Obrenovic, 2012) or Immunoactive from Bioiberica Spain (Wolvers et al, 2006).…”

“…At the beginning and the end of the study we also evaluated eNO levels using the American Thoracic Society recommendations (ATSCPSCPFL, 2002) as described in our previous studies (Vetvicka et al, 2013c).…”

“…A long-term focus of our laboratory is the research of how the environmental conditions affect the health of population. We are particularly interested in the possible regeneration of physical status of children exposed to environmental pollution of both internal and external environment (Lee et al, 2013;Richter et al, 2014;Vaclav et al, 2013a;2013b;2013c). We are focused most of all on children with chronic respiratory problems caused by living in industrial regions of northern Bohemia and northern Moravia where the extremely high concentration of environmental contamination helped to gain the term Black Spot of Europe.…”

β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects — Implications for coronavirus disease (COVID-19) immunotherapies

“…Macrophages and monocytes recognize β-glucans by various receptors present on their membrane (Vaclav et al, 2013). This recognition will result in the secretion of cytokines (Netea et al, 2008).…”