Placebo effects in pain

Colloca, Luana; Horin, Adam P.; Finniss, Damien G

doi:10.1002/9781118455968.ch9

Cited by 2 publications

(2 citation statements)

References 69 publications

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“…Descending modulation of pain involves cortical and subcortical brain structures, typically described as including dorsolateral and medial prefrontal cortices (dlPFC, mPFC), anterior cingulate cortex (ACC), anterior insula, amygdala, and brainstem regions including the periaqueductal grey (PAG), and rostroventromedial medulla (RVM) ( Bushnell et al, 2013 ). Involvement of these descending modulatory circuits has been reported in functional magnetic resonance imaging (fMRI) studies of placebo analgesia ( Colloca et al, 2016 ) and conditioned pain modulation ( Bogdanov et al, 2015 ; Youssef et al, 2016 ). In the diseased state, it is thought that the pain modulatory circuits become dysfunctional, where endogenous analgesic brainstem changes occur ( Mills et al, 2018 ) and maladaptive pain remains ( Sharav and Benoliel, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders

Ayoub

Seminowicz

Moayedi

2018

NeuroImage: Clinical

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Chronic orofacial pain (COFP) disorders are prevalent and debilitating pain conditions affecting the head, neck and face areas. Neuroimaging studies have reported functional and grey matter abnormalities, but not all the studies have reported consistent findings. Identifying convergent abnormalities across COFPs provides a basis for future hypothesis-driven research aimed at elucidating common CNS mechanisms. Here, we perform three coordinate-based meta-analyses according to PRISMA guidelines to elucidate the central mechanisms of orofacial pain disorders. Specifically, we investigated consistent patterns of: (1) brain function to experimental orofacial pain in healthy subjects, (2) structural and (3) functional brain abnormalities in COFP. We computed our coordinate-based meta-analyses using GingerALE. The experimental pain meta-analysis revealed increased brain activity in bilateral thalami, posterior mid-cingulate cortices, and secondary somatosensory cortices, the right posterior parietal cortex extending to the orofacial region of the right primary somatosensory cortex and the right insula, and decreased activity in the right somatomotor regions. The structural COFP meta-analysis identified consistent higher grey matter volume/concentration in the right ventral thalamus and posterior putamen of COFP patients compared to healthy controls. The functional COFP meta-analysis identified a consistent increase in brain activity in the left medial and posterior thalamus and lesser activity in the left posterior insula in COFP, compared to healthy controls. Overall, these findings provide evidence of brain abnormalities in pain-related regions, namely the thalamus and insula, across different COFP disorders. The convergence of thalamic abnormalities in both structure and function suggest a key role for this region in COFP pathophysiology.

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Section: Introductionmentioning

confidence: 99%

A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders

Ayoub

Seminowicz

Moayedi

2018

NeuroImage: Clinical

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“…In this study, the daily owner assessment NRS appeared to be a reliable and reproducible assessment tool. An advantage of daily NRS scoring was that potential bias from assessing isolated timepoints was avoided ( Colloca et al, 2016 ; Sanchis-Mora et al, 2019 ) and the endpoint is translatable across species. However, the disadvantage remains that the assessment of pain being owner dependent is anthropomorphic, therefore inferred by humans and consequently not objective.…”

Section: Alternative Neuropathic Pain Assessment Endpoints To Improvementioning

confidence: 99%

Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research

Fisher¹,

Lanigan

Upton³

et al. 2021

Front. Pharmacol.

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For patients suffering with chronic neuropathic pain the need for suitable novel therapies is imperative. Over recent years a contributing factor for the lack of development of new analgesics for neuropathic pain has been the mismatch of primary neuropathic pain assessment endpoints in preclinical vs. clinical trials. Despite continuous forward translation failures across diverse mechanisms, reflexive quantitative sensory testing remains the primary assessment endpoint for neuropathic pain and analgesia in animals. Restricting preclinical evaluation of pain and analgesia to exclusively reflexive outcomes is over simplified and can be argued not clinically relevant due to the continued lack of forward translation and failures in the clinic. The key to developing new analgesic treatments for neuropathic pain therefore lies in the development of clinically relevant endpoints that can translate preclinical animal results to human clinical trials. In this review we discuss this mismatch of primary neuropathic pain assessment endpoints, together with clinical and preclinical evidence that supports how bidirectional research is helping to validate new clinically relevant neuropathic pain assessment endpoints. Ethological behavioral endpoints such as burrowing and facial grimacing and objective measures such as electroencephalography provide improved translatability potential together with currently used quantitative sensory testing endpoints. By tailoring objective and subjective measures of neuropathic pain the translatability of new medicines for patients suffering with neuropathic pain will hopefully be improved.

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Placebo effects in pain

Cited by 2 publications

References 69 publications

A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders

A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders

Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research

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