Placebo treatment versus no treatment

Hróbjartsson, Asbjørn; Pc, Gøtzsche

doi:10.1002/14651858.cd003974

Cited by 30 publications

(22 citation statements)

References 223 publications

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“…Blinding is a cornerstone of randomized clinical trials in drug evaluation (Fergusson, Glass, Waring, & Shapiro, 2004;Gaudino & Herbert, 2005;Hrobjartsson & Gotzsche, 2003. Studies of pharmacotherapies for tobacco dependence have adhered to this tradition.…”

Section: Introductionmentioning

confidence: 99%

Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline

Hall

Gorecki

Reus

et al. 2007

CNTR

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The purpose of this study was to assess the relationship of beliefs about drug assignment and abstinence status in two treatment studies using nortriptyline hydrochloride as an adjunct to smoking cessation. Smokers (N=345) drawn from two clinical trials were asked at the final follow-up (FFU) at 52-64 weeks whether they believed they had received active or placebo drug; responses were obtained from 76% of the sample (n=262). Biochemically verified abstinence was collected at end of treatment (EOT) and FFU. In both studies, participants were correct in guessing drug assignment.At FFU, belief about drug assignment was not related to abstinence for either active or placebo participants. Participants who received active drug and who were smoking at EOT were more likely to believe they had received placebo than active drug participants who were abstinent at EOT. There was no significant relationship between belief about drug and abstinence status for placebo participants at EOT. Baseline variables did not significantly predict correctness of drug identification. Participants who experienced drug side effects not easily attributable to nicotine withdrawal were more likely to identify their drug assignment as nortriptyline. We conclude that experience during the active treatment period, including side effects and treatment success, may be related to belief about drug assignment, that the field would be well served by at least two assessments of blindness in clinical trials, and that discrepancy between these findings and those studying NRT may be due to differences in dependent variables.3

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Section: Introductionmentioning

confidence: 99%

Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline

Hall

Gorecki

Reus

et al. 2007

CNTR

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“…A possible benefit in outcome, particularly for treatment of pain, could not be clearly distinguished from random bias. 8 These data have recently been updated and the original findings confirmed. 9 The other approach is to compare treatments which include care, attention and time but limited medical benefit with placebo treatment.…”

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confidence: 89%

From the Editor

Allan¹

2006

Clinical Medicine

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“…A meta-analysis published by the Cochrane Database of Systematic Reviews in 2004 (Hróbjartsson & Gøtzsche, 2004) reported no evidence for important clinical effects from placebo interventions. Just six years later a follow-up meta-analysis (Hróbjartsson & Gøtzsche, 2010) found sufficient evidence to support the use of placebo as an effective treatment for pain.…”

Section: International Journal Of Transpersonal Studies 133 Placebo Rmentioning

confidence: 99%

A Possible Mechanism of Action for the Placebo Response: Human Biofield Activation Via Therapeutic Ritual

Brook¹,

Fauver

2014

IJTS

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Placebo treatment versus no treatment

Abstract: There was no evidence that placebo interventions in general have clinically important effects. A possible moderate effect on subjective continuous outcomes, especially pain, could not be clearly distinguished from bias.

Cited by 30 publications

References 223 publications

Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline

Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline

From the Editor

A Possible Mechanism of Action for the Placebo Response: Human Biofield Activation Via Therapeutic Ritual

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