Placebos and other comparative treatments.

Joyce, C. R. B.

doi:10.1111/j.1365-2125.1982.tb01380.x

Cited by 19 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2,15 The trial incorporated an active-treatment control group rather than a placebo control ( Figure 2). 16 Randomization Individuals were randomized in accordance with a computer-generated allocation schedule. Allocation was concealed in sequentially numbered, sealed envelopes that were not opened until randomization, 1 day before enrollment.…”

Section: Interventions and Treatmentsmentioning

confidence: 99%

Safety and Efficacy of 4‐Aminopyridine in Humans with Spinal Cord Injury: A Long‐Term, Controlled Trial

et al. 1999

View full text Add to dashboard Cite

Long-term oral administration of immediate-release 4-AP was associated with improvement in and recovery of sensory and motor function, enhanced pulmonary function, and diminished spasticity in patients with long-standing SCI. 4-Aminopyridine appears to be safe and relatively free from toxicity when administered orally over 3 months. Each patient who received immediate-release 4-AP 30 mg/day showed a response in one or more of the outcome measures.

show abstract

Section: Interventions and Treatmentsmentioning

confidence: 99%

Safety and Efficacy of 4‐Aminopyridine in Humans with Spinal Cord Injury: A Long‐Term, Controlled Trial

et al. 1999

View full text Add to dashboard Cite

show abstract

“…There are, how ever, certain reservations with regard to the need for, and the usefulness and efficacy of randomized clinical trials (RCTs) [34,35], or especially as regards placebo-controlled RCTs, there are doubts as to their legitimacy [36][37][38] and suggestions that they may even be misleading [39],…”

Section: Clinical Impact On the Evaluation Of Drug Response In Patientsmentioning

confidence: 99%

Placebo and Placebo Effect: Their Impact on the Evaluation of Drug Response in Patients

Dobrilla

Scarpignato

1994

Dig Dis

View full text Add to dashboard Cite

Placebo, defined as any therapeutic procedure, without any specific activity, given deliberately to have an effect on a patient, symptom, syndrome or disease, has a great impact in the evaluation of drug response. The possible pathways via which the possible effect brings about clinical and physiological changes remain unknown, but a humoral mechanism seems to be implicated in some placebo effects (e.g. placebo-induced analgesia). The placebo effect depends on many factors, including the type of patient, the personality of the physician, the doctor-patient relationship and the type and even the colour of the drug preparation. Placebo control is important particularly when the disease is characterized by frequent spontaneous periods of acute exacerbation and remission. Functional (such as dyspepsia and irritable bowel syndrome) and organic (such as peptic ulcer and inflammatory bowel disease) gastrointestinal diseases have got great benefit from placebo-controlled clinical trials. In such trials the more effective the placebo is, the more difficult it will be to demonstrate the efficacy of active drug in statistical terms. Nevertheless, provided the use of placebo be ethical for a given condition, placebo-controlled trials are the only objective way of assessing correctly drug response in patients.

show abstract

“…De bijbehorende denkwereld waarin de arts als allesbepaler figureert, is overigens slechts langzamerhand veranderd. Zo doet Joyce, in 1982 , nog steeds of patie¨ntendeelname aan een PDRT eigenlijk alleen een zaak is van de arts en meent hij dat als naar diens oordeel het effect van de behandeling verkleind zou kunnen worden als de patie¨nt verteld wordt dat hij een placebo kan krijgen, dit niet gezegd moet worden.…”

Section: Inleidingunclassified

De rol van ‘informed consent’ in placebo-gecontroleerde, dubbelblinde, gerandomiseerde onderzoeken naar de effectiviteit van psychofarmaca

Burg¹

2001

DITH

View full text Add to dashboard Cite

Placebos and other comparative treatments.

Cited by 19 publications

References 27 publications

Safety and Efficacy of 4‐Aminopyridine in Humans with Spinal Cord Injury: A Long‐Term, Controlled Trial

Safety and Efficacy of 4‐Aminopyridine in Humans with Spinal Cord Injury: A Long‐Term, Controlled Trial

Placebo and Placebo Effect: Their Impact on the Evaluation of Drug Response in Patients

De rol van ‘informed consent’ in placebo-gecontroleerde, dubbelblinde, gerandomiseerde onderzoeken naar de effectiviteit van psychofarmaca

Contact Info

Product

Resources

About