Placebos should be abandoned

Treasure, Wilfrid

doi:10.1136/bmj.313.7054.427c

Cited by 2 publications

(1 citation statement)

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“…In fact, a placebo effect could not be etymologically anticipated, and injection of any amount of inactive liquid into an inextensible and inflamed tendon is likely to be unacceptable. 16 Randomisation of arms (in the anatomical sense) was deemed appropriate since no residual and differential effect of previous local treatments was hypothesised. Randomisation was achieved by the flipping of a 1 euro coin.…”

Section: Methodsmentioning

confidence: 99%

N of 1, two contemporary arm, randomised controlled clinical trial for bilateral epicondylitis: a new study design

Scudeller

Fante

Perotti

et al. 2011

BMJ

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Objective To investigate the use of a novel study design in analysis of bilateral elbow pain.Design N of 1, two contemporary arm, open label, randomised controlled clinical trial.Setting A clinical epidemiologist at a university hospital in Pavia, Italy. Participants Two elbows with epicondylitis.Interventions Autologous platelet lysate versus "wait and see" strategy.Main outcome measures Visual analogue scale for pain on elbow extension and resisted wrist extension.Results Over six months' follow-up, the patient experienced bilateral improvement in pain, but higher in the treated arm, with a drop in visual analogue scale for pain from 28 to 4 for right (control) arm (drop of 24 points) and from 67 to 10.5 for left (treated) arm (drop of 56.5 points).Conclusions Platelet lysate might (or might not) work. Competing interests and lack of blinding might be relevant issues in the interpretation of trial results. However, the new study design can be applied to a number of conditions such as bilateral sport or trauma injuries, bilateral otitis, or any condition affecting chiral organs or limbs.

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Section: Methodsmentioning

confidence: 99%