Placental and Monocyte-derived Macrophages have Different Secretome

Garcia, Katia; Garcia, Vivian; Pérez, Jorge Sandelis; Duan, Fenghai; Meléndez, Loyda M.

doi:10.1016/j.antiviral.2008.01.073

Cited by 1 publication

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“…[7] Currently, there are only three publications reporting on the HIV-infected macrophage secretome. [7,15,16] These three studies revealed a surprisingly small number of differentially expressed proteins, potentially discouraging the justification of further secretome investigations. Of note, these studies were performed during the early stages of proteomics development when the sensitivity of protein identification was much less than nowadays.…”

Section: Quantitative Proteomics: Experimental Design To Maximize Thementioning

confidence: 99%

HIV and Proteomics: What We Have Learned from High Throughput Studies

Grabowska

Harwood

Ciborowski

2020

Proteomics Clinical Apps

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The accelerated development of technology over the last three decades has driven biological sciences to high-throughput profiling experiments, now broadly referred to as systems biology. The unprecedented improvement of analytical instrumentation has opened new avenues for more complex experimental designs and expands the knowledge in genomics, proteomics, and other omics fields. Despite the collective efforts of hundreds of researchers, gleaning all the expected information from omics experiments is still quite far. This paper summarizes what has been learned from high-throughput proteomics studies thus far, and what is believed should be done to reveal even more valuable information from such studies. It is drawn from the background in using proteomics to study human immunodeficiency virus 1 infection of macrophages and/or T cells, but it is believed that some conclusions will be more broadly applicable.

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