Placental apoptosis in recurrent miscarriage

Abstract

Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage (RM). Placental tissue samples were collected from 40 women with RM (study group) and 30 women with sporadic spontaneous abortion (control group). Samples were prepared and stained immunohistochemically with markers for both the apoptotic protein (p53) and anti-apoptotic Bcl-2 antibodies. Our results showed that expression of the apoptotic (p53) protein was significantly increased in the placental tissues of the RM group (p = 0.003). By contrast, the expression of anti-apoptotic (Bcl-2) antibodies was significantly increased in the placental tissues of the control group (p = 0.025). We concluded that placental apoptosis plays a crucial role in pregnancy continuation. However, increased p53 expression in placental tissue in early pregnancy could negatively affect pregnancy continuation.

A Traditional Chinese Medicine Herb Mixture Qingjie Fuzheng Granules Inhibits Hepatocellular Carcinoma Cells Growth by Inducing Apoptosis

“…Perturbed apoptosis regulation is a major causative factor for cancer pathogenesis, including HCC. 7 – 9 In 1972, Kerret and colleagues 10 defined apoptosis as a form of programmed cell death that depends on adenosine triphosphate and is distinct from necrotic cell death. 8 , 9 Many studies have implicated the role of apoptosis in the pathogeneses of multiple diseases in humans and animals.…”

“… 7 – 9 In 1972, Kerret and colleagues 10 defined apoptosis as a form of programmed cell death that depends on adenosine triphosphate and is distinct from necrotic cell death. 8 , 9 Many studies have implicated the role of apoptosis in the pathogeneses of multiple diseases in humans and animals. 11 – 15 In development of anticancer drugs, some of the main approaches used are to develop drugs that inhibit excessive growth of tumor cells or promote apoptosis in tumor cells.…”

Does Enoxaparin treatment have any effects on the placenta in women with unexplained histories of habitual abortion? A case control study

“…Several studies have shown that antiapoptotic Bcl-2 levels are lower in the placenta of patients with habitual abortions than in the normal population. 12,29,30 Furthermore, it has been indicated that Bcl-2 expression, which is low in the early weeks of normal pregnancy, increases during late weeks of pregnancy. This increase may provide continuity for the placenta.…”

“…11 Apoptosis is seen more frequently in the placenta of patients with habitual abortion than in that of patients with spontaneous abortion. 12 In addition, it has been shown that perivillous fibrin deposition, chronic villitis, chronic histiocytic intervillositis, and plasma cell deciduitis are higher in chromosomally normal habitual abortions than in spontaneous abortions. 13,14,15 Previous studies have also shown that placental invasion disorder is high, rather than thrombosis, in patients with habitual abortion.…”

Toxicants Associated with Spontaneous Abortion in the Comparative Toxicogenomics Database (CTD)

“…Apoptosis and cell death is associated with SA. Placentas from women with recurrent SA have increased levels of apoptosis compared to women with normal pregnancies (Atia 2017). Exposures to toxic chemicals such as polycyclic aromatic hydrocarbons induce apoptotic pathways and lead to embryonic loss in animal models, a proposed mechanism explaining higher miscarriage rates in women who smoke (Detmar et al 2006).…”