Placental baseline conditions modulate the hyperoxic BOLD-MRI response

Sinding, Marianne; Peters, David A.; Poulsen, Sofie S.; Frøkjær, Jens Brøndum; Christiansen, Ole Bjarne; Petersen, Astrid; Uldbjerg, Niels; Sørensen, Anne Scott

doi:10.1016/j.placenta.2017.07.213

Placenta

2017

DOI: 10.1016/j.placenta.2017.07.213

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Placental baseline conditions modulate the hyperoxic BOLD-MRI response

Marianne Sinding

David A. Peters

Sofie S. Poulsen

et al.

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Cited by 19 publications

(63 citation statements)

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“…A promising noninvasive alternative for detecting IPD conditions is magnetic resonance imaging (MRI). MRI can be used to characterize oxygenation in the placenta through quantification of the transverse relaxation rate (

{normalR}_{2}^{*} = 1 / {normalT}_{2}^{*}

) .

{normalR}_{2}^{*}

is known to increase due to local field inhomogeneities caused by deoxyhemoglobin, the form of hemoglobin without oxygen.…”

mentioning

confidence: 99%

“…

{normalR}_{2}^{*}

is known to increase due to local field inhomogeneities caused by deoxyhemoglobin, the form of hemoglobin without oxygen. Thus,

{normalR}_{2}^{*}

is higher (or

{normalT}_{2}^{*}

is lower) in hypoxic tissues than in normoxic tissues . Despite the potential of MRI as a diagnostic tool to detect IPD via

{normalR}_{2}^{*}

mapping, there is limited understanding of the range of placental

{normalR}_{2}^{*}

across gestational age (GA), within the structure of the placenta, and among normal and abnormal pregnancies.…”

mentioning

confidence: 99%

“…Previous investigations of

{normalR}_{2}^{*}

{normalT}_{2}^{*}

mapping in the placenta have been performed typically at later GAs from 20–40 weeks using a 2D breath‐hold (BH) Cartesian

{normalR}_{2}^{*}

mapping technique; with only one very recent study including earlier GAs of 16–40 weeks . If IPD is detected at later GA, intervention may not be possible or may have limited effectiveness .…”

mentioning

confidence: 99%

“…In addition, most investigations of

{normalR}_{2}^{*}

{normalT}_{2}^{*}

mapping in the placenta were performed using 1.5T MRI . Some of these studies showed a significant decrease in nominal placental

{normalT}_{2}^{*}

as GA increased but in one study quantifying

{normalR}_{2}^{*}

, this trend was not significant . Compared to 1.5T, 3T MRI may provide higher sensitivity to changes in

{normalR}_{2}^{*}

for detecting IPD.…”

mentioning

confidence: 99%

See 3 more Smart Citations

3D mapping of the placenta during early gestation using free‐breathing multiecho stack‐of‐radial MRI at 3T

Armstrong

Liu

Martin

et al. 2018

Magnetic Resonance Imaging

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show abstract

{normalR}_{2}^{*} = 1 / {normalT}_{2}^{*}

) .

{normalR}_{2}^{*}

is known to increase due to local field inhomogeneities caused by deoxyhemoglobin, the form of hemoglobin without oxygen.…”

mentioning

confidence: 99%

“…

{normalR}_{2}^{*}

is known to increase due to local field inhomogeneities caused by deoxyhemoglobin, the form of hemoglobin without oxygen. Thus,

{normalR}_{2}^{*}

is higher (or

{normalT}_{2}^{*}

is lower) in hypoxic tissues than in normoxic tissues . Despite the potential of MRI as a diagnostic tool to detect IPD via

{normalR}_{2}^{*}

mapping, there is limited understanding of the range of placental

{normalR}_{2}^{*}

across gestational age (GA), within the structure of the placenta, and among normal and abnormal pregnancies.…”

mentioning

confidence: 99%

“…Previous investigations of

{normalR}_{2}^{*}

{normalT}_{2}^{*}

mapping in the placenta have been performed typically at later GAs from 20–40 weeks using a 2D breath‐hold (BH) Cartesian

{normalR}_{2}^{*}

mapping technique; with only one very recent study including earlier GAs of 16–40 weeks . If IPD is detected at later GA, intervention may not be possible or may have limited effectiveness .…”

mentioning

confidence: 99%

“…In addition, most investigations of

{normalR}_{2}^{*}

{normalT}_{2}^{*}

mapping in the placenta were performed using 1.5T MRI . Some of these studies showed a significant decrease in nominal placental

{normalT}_{2}^{*}

as GA increased but in one study quantifying

{normalR}_{2}^{*}

, this trend was not significant . Compared to 1.5T, 3T MRI may provide higher sensitivity to changes in

{normalR}_{2}^{*}

for detecting IPD.…”

mentioning

confidence: 99%

See 2 more Smart Citations

3D mapping of the placenta during early gestation using free‐breathing multiecho stack‐of‐radial MRI at 3T

Armstrong

Liu

Martin

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…The NIH Human Placenta Project is the driving force behind recent significant advancements in placental imaging and real-time functional assessment capabilities [5]. Specifically, functional imaging of placental blood flow is generating unique data resources that provide comprehensive in vivo characterization of pregnancies, in addition to documented clinical outcomes [4,6,7]. In turn, the next step is to derive a representative and reproducible comprehensive placental sampling regime to maximize the potential for correlative ex vivo studies.…”

mentioning

confidence: 99%

A Standardized Method for Collection of Human Placenta Samples in the Age of Functional Magnetic Resonance Imaging

et al. 2019

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Current methods for placental tissue collection assess a delivered organ without direct functional correlates; therefore, the four-quadrant biopsy protocol utilized by many researchers may provide reasonable representation of tissue across a large organ, and offer a snapshot for molecular analysis of the placenta. However, the recent impetus to understand the placenta in real time, and the use of functional imaging to comprehend placental biology, warrants a different sampling approach. Here we present a method to standardize placental tissue collection in a format designed to facilitate correlation of in vivo function with ex vivo assessments. Additionally, we draw comparisons to the quadrant biopsy regimen, and highlight a pathological case of placental infarction detected by in utero imaging.

show abstract

Separating fetal and maternal placenta circulations using multiparametric MRI

Melbourne

Aughwane

Sokolska

et al. 2018

Magnetic Resonance in Med

127

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PurposeThe placenta is a vital organ for the exchange of oxygen, nutrients, and waste products between fetus and mother. The placenta may suffer from several pathologies, which affect this fetal‐maternal exchange, thus the flow properties of the placenta are of interest in determining the course of pregnancy. In this work, we propose a new multiparametric model for placental tissue signal in MRI.MethodsWe describe a method that separates fetal and maternal flow characteristics of the placenta using a 3‐compartment model comprising fast and slowly circulating fluid pools, and a tissue pool is fitted to overlapping multiecho T2 relaxometry and diffusion MRI with low b‐values. We implemented the combined model and acquisition on a standard 1.5 Tesla clinical system with acquisition taking less than 20 minutes.ResultsWe apply this combined acquisition in 6 control singleton placentas. Mean myometrial T2 relaxation time was 123.63 (±6.71) ms. Mean T2 relaxation time of maternal blood was 202.17 (±92.98) ms. In the placenta, mean T2 relaxation time of the fetal blood component was 144.89 (±54.42) ms. Mean ratio of maternal to fetal blood volume was 1.16 (±0.6), and mean fetal blood saturation was 72.93 (±20.11)% across all 6 cases.ConclusionThe novel acquisition in this work allows the measurement of histologically relevant physical parameters, such as the relative proportions of vascular spaces. In the placenta, this may help us to better understand the physiological properties of the tissue in disease.

show abstract

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Placental baseline conditions modulate the hyperoxic BOLD-MRI response

Cited by 19 publications

References 1 publication

3D mapping of the placenta during early gestation using free‐breathing multiecho stack‐of‐radial MRI at 3T

3D mapping of the placenta during early gestation using free‐breathing multiecho stack‐of‐radial MRI at 3T

A Standardized Method for Collection of Human Placenta Samples in the Age of Functional Magnetic Resonance Imaging

Separating fetal and maternal placenta circulations using multiparametric MRI

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