Placental characteristics of selective birth weight discordance in diamniotic-monochorionic twin gestations

Paepe, Monique E. De; Shapiro, Steven K.; Young, Lawrence E.; Luks, François I.

doi:10.1016/j.placenta.2010.02.018

Cited by 108 publications

(93 citation statements)

References 30 publications

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“…More importantly, apart from the difference in genetic resemblance, the main determinants of growth discordance appear to be the same in both monochorionic and dichorionic twins, namely placental and chord function. 30,31 The other evident and undisputable difference between monozygotic and dizygotic twins is their degree of relatedness. Although dizygotic twins are genetically related like any full siblings, monozygotic twins share the same genetic setup.…”

Section: Discussionmentioning

confidence: 99%

Birth Weight Predicts Risk of Cardiovascular Disease Within Dizygotic but Not Monozygotic Twin Pairs

et al. 2011

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Background-The widely reported inverse association between birth weight and risk of cardiovascular disease (CVD) has sparked theories about early life determinants of adult disease. Within-twin-pair analysis provides a unique opportunity to investigate whether factors shared within twin pairs influence the association. Methods and Results-In a population-based cohort of like-sexed twins with known zygosity born in Sweden from 1926 to 1958, disease-discordant twin pairs were identified through linkage to the National Inpatient and Cause of Death registers between 1973 and 2006. Co-twin-control analyses were performed on twins discordant for cardiovascular disease (nϭ3884), coronary heart disease (nϭ2668), and stroke (nϭ1372). Overall, inverse associations between birth weight and risk of cardiovascular diseases were seen within dizygotic but not monozygotic twin pairs. In dizygotic twins, the odds ratios for a 1-kg within-pair increase in birth weight were 0.74 (95% confidence interval, 0.56 to 0.98) for coronary heart disease and 0.57 (95% confidence interval, 0.37 to 0.88) for stroke. Conversely, no statistically significant associations were found within monozygotic twins (for coronary heart disease: odds ratio, 1.10; 95% confidence interval, 0.73 to 1.68; for stroke: odds ratio, 0.92; 95% confidence interval, 0.48 to 1.80). Conclusions-We found an association between birth weight and risk of cardiovascular disease within disease-discordant dizygotic but not monozygotic twin pairs. This indicates that the association between birth weight and cardiovascular disease could be a result of common causes, and that factors that vary within dizygotic but not monozygotic twin pairs may help identify them. (Circulation. 2011;123:2792-2798.)

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Section: Discussionmentioning

confidence: 99%

Birth Weight Predicts Risk of Cardiovascular Disease Within Dizygotic but Not Monozygotic Twin Pairs

et al. 2011

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“…10,23,106 Placental and umbilical cord-specific characteristics are found with an increased incidence in twin birthweight discordance. 107 The evaluation of placenta to birthweight ratio or fetal to placental weight ratio (FPR) also provides indirect information on placental development and function during pregnancy. In singleton and twin pregnancies, an abnormal FPR is a good Fetal:placental weight ratio as a function of gestational age in singleton and twin gestations Evolution of fetal to placental weight ratio during gestation in singleton, monochorionic, and dichorionic twin pregnancies.…”

Section: Postpartum Placental Examinationmentioning

confidence: 99%

Anomalies of the placenta and umbilical cord in twin gestations

Hubinont¹,

Lewi

Bernard³

et al. 2015

American Journal of Obstetrics and Gynecology

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“…Several authors reported a strong correlation between VCI and the onset of TTTS [16,17], whereas other studies were not in agreement [15,18,19]. In addition, the correlation among VCI and intrauterine fetal growth restriction and severe birth weight discordance has also been reported [20,21,22]. However, these previous reports were inconclusive regarding the actual incidence of VCI, as well as the natural progression of monochorionic twin pregnancies because they investigated only tertiary referral centers and included a high number of high-risk cases.…”

Section: Introductionmentioning

confidence: 99%

Significance of Velamentous Cord Insertion for Twin-Twin Transfusion Syndrome

et al. 2015

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Introduction: The objective of this study was to evaluate the actual association between velamentous cord insertion (VCI) and twin-twin transfusion syndrome (TTTS) in the native cohort concerning the natural history of monochorionic twin pregnancies. Material and Methods: All monochorionic diamniotic twin pregnancies who received prenatal care from <16 weeks of gestation until delivery at our center between 2004 and 2013 were included in this retrospective cohort study. Macroscopically defined cord insertion site was recorded as velamentous, marginal, or central. The effects of VCI on TTTS and a composite of adverse outcomes, including abortion, death, and neurological morbidities ≤28 days of age, were evaluated with a multiple logistic regression model. Results: A total of 357 monochorionic diamniotic twin pregnancies were analyzed. VCI in both twins was noted in 2.5% of cases and VCI in at least one twin was noted in 22.1% of cases. The incidence of TTTS was 8.4%; the incidence of a composite of adverse outcomes in at least one twin was 9.8%. There was no correlation between VCI and TTTS as well as a composite of adverse outcomes. Discussion: VCI in monochorionic twin pregnancies was not a risk factor for TTTS and severe perinatal morbidities.

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Placental characteristics of selective birth weight discordance in diamniotic-monochorionic twin gestations

Cited by 108 publications

References 30 publications

Birth Weight Predicts Risk of Cardiovascular Disease Within Dizygotic but Not Monozygotic Twin Pairs

Birth Weight Predicts Risk of Cardiovascular Disease Within Dizygotic but Not Monozygotic Twin Pairs

Anomalies of the placenta and umbilical cord in twin gestations

Significance of Velamentous Cord Insertion for Twin-Twin Transfusion Syndrome

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