Placental Chorangiosis: The Association with Oxidative Stress and Angiogenesis

Barut, Aykut; Barut, Figen; Kandemır, Nilüfer Onak; Aktunç, Erol; Arıkan, İlker; Harma, Müge; Harma, Mehmet; Gün, Banu Doğan

doi:10.1159/000332370

Cited by 20 publications

(13 citation statements)

References 80 publications

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“…Placental dysfunction may lead to various clinical phenotypes, such as intrauterine growth restriction (IUGR), the delivery of small-for-gestational-age neonates, preterm birth, and preeclampsia [9–15]. A growing body of evidence supports the concept that IUGR may be due to a decreased utero-placental blood flow and subsequent chronic hypoxia and/or ischemia-reperfusion injury of the placenta, as well as a reduced placental transport function [16– 18]. Murine models are commonly used to understand and mimic the mechanisms of disease in human obstetrical syndromes, such as preeclampsia, IUGR, and preterm birth [19–22].…”

Section: Introductionmentioning

confidence: 99%

Quantitative T2 Changes and Susceptibility-Weighted Magnetic Resonance Imaging in Murine Pregnancy

Krishnamurthy

Szalai

Neelavalli³

et al. 2014

Gynecol Obstet Invest

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Objective: To evaluate gestational age-dependent changes in the T2 relaxation time in normal murine placentas in vivo. The role of susceptibility-weighted imaging (SWI) in visualization of the murine fetal anatomy was also elucidated. Methods: Timed-pregnant CD-1 mice at gestational day (GD) 12 and GD17 underwent magnetic resonance imaging. Multi-echo spin echo and SWI data were acquired. The placental T2 values on GD12 and GD17 were quantified. To account for the influence of systemic maternal physiological factors on placental perfusion, maternal muscle was used as a reference for T2 normalization. A linear mixed-effects model was used to fit the normalized T2 values, and the significance of the coefficients was tested. Fetal SWI images were processed and reviewed for venous vasculature and skeletal structures. Results: The average placental T2 value decreased significantly on GD17 (40.17 ± 4.10 ms) compared to the value on GD12 (55.78 ± 8.13 ms). The difference in normalized T2 values also remained significant (p = 0.001). Using SWI, major fetal venous structures like the cardinal vein, the subcardinal vein, and the portal vein were visualized on GD12. In addition, fetal skeletal structures could also be discerned on GD17. Conclusion: The T2 value of a normal murine placenta decreases with advancing gestation. SWI provided clear visualization of the fetal venous vasculature and bony structures.

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Section: Introductionmentioning

confidence: 99%

Quantitative T2 Changes and Susceptibility-Weighted Magnetic Resonance Imaging in Murine Pregnancy

Krishnamurthy

Szalai

Neelavalli³

et al. 2014

Gynecol Obstet Invest

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“…17,11 Barut et al in 2012 studied placental chorangiosis and found that capillary hyperplasia is due to chronic placental low-grade hypoxemia or hypoperfusion. 18…”

Section: Discussionmentioning

confidence: 99%

Histopathological Study of Villous Hypervascularity and Chorangiosis at Different Maternal Hemoglobin Levels

Kiran¹,

Mudassar²,

Adeel³

2018

IJCMR

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Introduction: Placenta has a remarkable reserve capacity to survive in the harmful environment, but some of the damaging factors, especially maternal anemia may have negating effects on placenta which might compromise the fetal well-being. Decreased hemoglobin level in pregnancy is associated with villous hypervascularity and chorangiosis, which can be assessed for diagnostic purposes because it has been considered as a result of placental hypoxia caused by maternal anemia. The objective of this study is to assess the morphological pattern of villous hypervascularity and chorangiosis at different maternal hemoglobin levels. Material and methods:This descriptive study was carried out over a period of 2 years in a tertiary care hospital. Nonprobability convenience sampling was done. Placentas were obtained from 100 full-term pregnant women having different hemoglobin levels. After processing and staining, the slides were examined under light microscope and number of blood vessels were calculated in 10 villi in 10 non-infarcted areas in 3 random fields per each slide under 10X objective. Results:At normal hemoglobin level, all the chorionic villi showed normal number of blood vessels, while at 10.0-10.9 gm/dl, 50% (12 out of 24 cases), at 7-9.9 gm/dl, 36.4% (12 out of 33 cases) and at < 7 gm/dl, 72.2% (13 out of 18 cases) placental specimens showed hypervascularity. Chorangiosis was not seen at hemoglobin level ≥ 10.0 gm/dl while 18.1% (6 out of 33 cases) having hemoglobin level 7-9.9 gm/dl and 27.8% specimens having hemoglobin level ≤ 7.0 gm/dl (5 out of 18 cases) showed chorangiosis Conclusion:In current study number of capillaries per chorionic villi were found to be significantly more at decreasing concentration of hemoglobin, displaying adaptive alterations

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“…The result is consistent with the fact that stillbirth usually occurs after 35 weeks of gestation before labor in ICP. The possible mechanism is that low CRH may diminish the maximum compensatory increase in uteroplacental-fetal circulation in response to uterine stress compared to normal pregnancy [3] and damage the diastolic function of the uteroplacental-fetal vascular unit, thus decreasing placental blood flow, vascular perfusion, and blood oxygen volume reserve, resulting in an increased risk of perinatal hypoxia and death [14,15]. …”

Section: Discussionmentioning

confidence: 99%

Reduced Plasma Corticotropin-Releasing Hormone Levels during Late Gestation in Patients with Intrahepatic Cholestasis of Pregnancy

Huang

Liu²,

He³

et al. 2014

Gynecol Obstet Invest

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Objective: Intrahepatic cholestasis of pregnancy (ICP) may lead to sudden onset of stillbirth, which most likely is related to uteroplacental insufficiency and dysregulation of the fetal blood supply. The relaxing effect of corticotropin-releasing hormone (CRH) on blood vessels was measured to examine the role of CRH in the pathogenesis of ICP. Methods: Eighty normal pregnant women and 80 ICP patients were divided into four groups of 20 cases, respectively, each based on gestational age from week 34 to 37. Radioimmunoassay was used to measure CRH in plasma samples collected from all of the subjects. Results: Plasma CRH increased markedly from week 34 to 37 in both ICP and healthy patients, but the increase was lower in the ICP group. Plasma CRH was 322 ± 61 pg/ml in mild ICP cases at 37 weeks' compared to 1,066 ± 173 pg/ml in controls (p < 0.05), but only 218 ± 128 pg/ml in severe ICP (p < 0.05). Plasma CRH was significantly lower at all other measured time points in patients with severe ICP. In ICP patients, there was a negative correlation between plasma CRH and total bile acid (TBA). Conclusion: A limited increasing CRH level and negative correlation of CRH with TBA were unveiled in ICP patients.

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Placental Chorangiosis: The Association with Oxidative Stress and Angiogenesis

Cited by 20 publications

References 80 publications

Quantitative T2 Changes and Susceptibility-Weighted Magnetic Resonance Imaging in Murine Pregnancy

Quantitative T2 Changes and Susceptibility-Weighted Magnetic Resonance Imaging in Murine Pregnancy

Histopathological Study of Villous Hypervascularity and Chorangiosis at Different Maternal Hemoglobin Levels

Reduced Plasma Corticotropin-Releasing Hormone Levels during Late Gestation in Patients with Intrahepatic Cholestasis of Pregnancy

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