2019
DOI: 10.3389/fped.2019.00154
|View full text |Cite
|
Sign up to set email alerts
|

Placental ESRRG-CYP19A1 Expressions and Circulating 17-Beta Estradiol in IUGR Pregnancies

Abstract: Introduction: Sex steroids are regulating factors for intrauterine growth. 17-β Estradiol (E2) is particularly critical to a physiological pregnancy, as increased maternal E2 was correlated to lower fetal weight at delivery. The placenta itself is a primary source of estrogens, synthetized from cholesterol precursors. Cytochrome P450 aromatase (encoded by CYP19A1 gene) is a rate-limiting enzyme for E2 biosynthesis. CYP19A1 transcription is supported by E… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
11
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 21 publications
(12 citation statements)
references
References 64 publications
1
11
0
Order By: Relevance
“…Human placentas were collected immediately after elective cesarean section, cleaned of excess blood and then weighed after discarding the membranes and cord from the disc. Biometric measurements were performed as previously described [ 25 , 26 ]. Briefly, placental area was estimated by calculating the area of an ellipse from the diameters (D × d × π/4).…”
Section: Methodsmentioning
confidence: 99%
“…Human placentas were collected immediately after elective cesarean section, cleaned of excess blood and then weighed after discarding the membranes and cord from the disc. Biometric measurements were performed as previously described [ 25 , 26 ]. Briefly, placental area was estimated by calculating the area of an ellipse from the diameters (D × d × π/4).…”
Section: Methodsmentioning
confidence: 99%
“…CYP19 A1 is one of the multiple enzymes involved in placental steroid biosynthesis and its endocrine function. Its alteration had been detected in pre-eclamptic and intrauterine growth retardation placentas [ 26 , 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…CYP19A1 activity was influenced by 5 μg/L perchlorate, while its activity was inhibited with the highest perchlorate concentration. This might represent the inhibitory effect of ROS on CYP19A1 activity in placenta cells [ 26 , 27 ]. Thereby, the reduction of CYP 19 activity can have harmful consequences during pregnancy.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations