2018
DOI: 10.2174/1381612824666180125164429
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Placental Exosomes During Gestation: Liquid Biopsies Carrying Signals for the Regulation of Human Parturition

Abstract: Parturition is defined as the action or process of giving birth to offspring. Normal term human parturition ensues following the maturation of fetal organ systems typically between 37 and 40 weeks of gestation. Our conventional understanding of how parturition initiation is signaled revolves around feto-maternal immune and endocrine changes occurring in the intrauterine cavity. These changes in turn correlate with the sequence of fetal growth and development. These important physiological changes also result i… Show more

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Cited by 51 publications
(33 citation statements)
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“…Currently, there is an ongoing discussion in the literature about the heterogeneity of EVs and the correct nomenclature; however, the majority of studies have focused on small EVs such as exosomes. sEVs (< 200 nm), which are abundant in saliva and are emerging as a potential source for the development of diagnostic tools for a variety of diseases [13][14][15][16], owing to their components-nucleic acids (microRNAs, DNAs and other RNAs), lipids and proteins. Salivary sEVs have not been widely explored as a diagnostic tool in periodontology, probably because the methodology for their isolation is still developing.…”
Section: Introductionmentioning
confidence: 99%
“…Currently, there is an ongoing discussion in the literature about the heterogeneity of EVs and the correct nomenclature; however, the majority of studies have focused on small EVs such as exosomes. sEVs (< 200 nm), which are abundant in saliva and are emerging as a potential source for the development of diagnostic tools for a variety of diseases [13][14][15][16], owing to their components-nucleic acids (microRNAs, DNAs and other RNAs), lipids and proteins. Salivary sEVs have not been widely explored as a diagnostic tool in periodontology, probably because the methodology for their isolation is still developing.…”
Section: Introductionmentioning
confidence: 99%
“…Small extracellular vesicles (sEV) are nano-scaled (<200 nm), stable lipid bilayer membrane surrounded structures that are abundant in biofluids (e.g., saliva and plasma) [1]. sEV have attracted considerable interest as a liquid biopsy source for the discovery of biomarkers, as their cargos (RNA, DNA, and protein) can be considered to be biomolecular "fingerprints" of the releasing cell and its metabolic status [1][2][3][4][5]. Recent reports indicate that salivary sEV are potential diagnostic tools for local conditions such as oral cancer [6], as well as systemic diseases such as inflammatory bowel disease [7] and lung cancer [8].…”
Section: Introductionmentioning
confidence: 99%
“…A number of publications have addressed placental EVs and their potential role in pregnancy and its complications . Several ex vivo (eg, placental perfusion) and in vivo systems have been used as a source of EVs.…”
Section: Discussionmentioning
confidence: 99%