Placental Expression of VEGF, PlGF and their Receptors in a Model of Placental Insufficiency—Intrauterine Growth Restriction (PI-IUGR)

Regnault, Timothy R. H.; Orbus, Ryan J; Vrijer, Barbra de; Davidsen, Meredith L.; Galan, Henry L.; Wilkening, Randall B.; Anthony, Russell V.

doi:10.1053/plac.2001.0757

Cited by 113 publications

(100 citation statements)

References 63 publications

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“…By contrast, at day 55 p.c. in our sheep FGR pregnancies, VEGF, Ang 1, Ang 2 and Tie 2 expression are all increased within the fetal cotyledon [47,48], indicative of accelerated angiogenesis within these placentae. These data, obtained during early placental development in our FGR pregnancies are not available for human FGR pregnancies, and suggest that accelerated vasculogenesis/angiogenesis during early placental development may set the stage for the abnormal placental vasculature structure, increased placental vascular resistance and impaired placental function described for human and sheep FGR pregnancies.…”

Section: Placental Development In Compromised Pregnanciesmentioning

confidence: 54%

The pregnant sheep as a model for human pregnancy

2008

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Successful outcome of human pregnancy not only impacts the quality of infant life and well-being, but considerable evidence now suggests that what happens during fetal development may well impact health and well-being into adulthood. Consequently, a thorough understanding of the developmental events that occur between conception and delivery is needed. For obvious ethical reasons, many of the questions remaining about the progression of human pregnancy can not be answered directly, necessitating the use of appropriate animal models. A variety of animal models exist for the study of both normal and compromised pregnancies, including laboratory rodents, non-human primates and domestic ruminants. While all of these animal models have merit, most suffer from the inability to repetitively sample from both the maternal and fetal side of the placenta, limiting their usefulness in the study of placental or fetal physiology under non-stressed in vivo conditions. No animal model truly recapitulates human pregnancy, yet the pregnant sheep has been used extensively to investigate maternal-fetal interactions. This is due in part to the ability to surgically place and maintain catheters in both the maternal and fetal vasculature, allowing repeated sampling from non-anesthetized pregnancies. Considerable insight has been gained on placental oxygen and nutrient transfer and utilization from use of pregnant sheep. These findings were often confirmed in human pregnancies once appropriate technologies became available. The purpose of this review is to provide an overview of human and sheep pregnancy, with emphasis placed on placental development and function as an organ of nutrient transfer.

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Section: Placental Development In Compromised Pregnanciesmentioning

confidence: 54%

The pregnant sheep as a model for human pregnancy

2008

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“…PlGFs, angiogenic growth factors, and their receptors are essential for placental vascular development (12). In this study, we examined the expression level of PlGF-1 and PlGF-2 mRNAs in both the normal and PIH placentas at term and found a decreased mRNA level of PlGF-2 in PIH placentas by Northern blots and in situ hybridization.…”

Section: Discussionmentioning

confidence: 96%

“…Ideal placental development requires an adequate and organized interaction of vascular growth factors and their receptors, including VEGF and PlGF; both VEGF and PlGF act through their common tyrosine kinase receptors (12). The expression of VEGF and KDR (PlGFR-2/VEGFR-2) is strongest during early gestation and decrease as pregnancy advances (13)(14)(15) while PlGF and Flt-1 (PlGFR-1/ VEGFR-1) increase towards term (16,17).…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Placenta Growth Factors and Their Receptors In the Normal and Pregnancy-Induced Hypertensive Human Placentas

et al. 2003

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Placental development requires extensive angiogenesis and the invasion of the maternal decidua by the trophoblasts. Adequate and organized interaction of vascular endothelial growth factors (VEGF), placenta growth factors (PlGF), and their receptors are essential for a normal development and function of the placenta. In this study, we evaluated the expressions of PlGFs and their receptors, mRNAs by Northern blotting, in situ hybridization and RT-PCR in the normal and pregnancy-induced hypertensive (PIH) placentas. The expression level of PlGF-2 mRNA was lower in the PIH placentas compared to control as assessed by Northern blotting and in situ hybridization. PlGF mRNA was mainly localized to the vasculosyncytial membrane of placental villi and villous stroma. The expression of PlGF receptor-1 (PlGFR-1) was significantly increased in the PIH placentas compared to the normal ones. These results suggest that the alteration of PlGF-2 and PlGFR-1 mRNA expressions in the placenta are related to the pathogenesis of PIH.

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“…Its regulate physiological and pathological angiogenesis which causes an increase in vascular permeability that mediated after administration of luteinizing hormone (LH) and human chorionic gonadotrophin(HCG) during ovarian stimulation cycles and have been implicated as a major factor in the pathophysiology of OHSS as high concentrations of VEGF have been found in ascites from patients with OHSS (5,6) . VEGF involved in the proliferation of capillaries that accompanies the selection of the preovulatory follicle resulting in an increased supply of nutrients and precursors, and therefore supporting the growth of the dominant follicle and its action required for successful blastocyst implantation in the rhesus monkey (7) and also thought to be important for placental development (8) .…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

The Effect of Different Ovarian Stimulation Protocols on Vascular Endothelial Growth Factor (Vegf) Concentration in the Serum and Follicular Fluid of Women With Pcos Undergoing Icsi/Ivf.

Aboudy¹,

RedaAlKawaz²,

Ani³

2017

IJAR

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Objective:To measure the concentration of vascular endothelial growth factor (VEGF) in serum and follicular fluid of patients with PCOS at day of ova pick up after using of different IVF/ICSI protocols and to assess the pregnancy outcome. Study design: A total of 90 infertile women (55 women with Polycystic ovary syndrome and the other 35 women as a control (non PCOS) undergoing controlled ovarian hyperstimulation for intracytoplasmic sperm injection cycle were prospectively recruited for this study in High Institute of Infertility Diagnosis and Assisted Reproductive Technology / AL-Nahrian University and Kamal ALSamarai Hospital, center of fertility and IVF (Baghdad/Iraq) during the period from December 2015 to the end of April 2017.The fifty five PCOS women were divided into three groups: twenty five (25) infertile women have had PCOS undergoing long Agonist protocol for ICSI cycle, fifteen (15) infertile women have had PCOS undergoing Antagonist protocol for ICSI and fifteen (15) infertile women have had PCOS undergoing short Agonist protocol for ICSI. The controlled group included 35 women were free of signs and symptoms of PCOS with regular cycles and no endocrine abnormalities undergoing ICSI cycle (15 infertile women underwent long agonist protocol, 10 women underwent short agonist and 10 women underwent antagonist protocol). In all patients, serum and follicular fluid VEGF levels were measured on the day of oocyte retrieval by using Enzyme linked immuno sorbent assay.

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Placental Expression of VEGF, PlGF and their Receptors in a Model of Placental Insufficiency—Intrauterine Growth Restriction (PI-IUGR)

Cited by 113 publications

References 63 publications

The pregnant sheep as a model for human pregnancy

The pregnant sheep as a model for human pregnancy

Differential Expression of Placenta Growth Factors and Their Receptors In the Normal and Pregnancy-Induced Hypertensive Human Placentas

The Effect of Different Ovarian Stimulation Protocols on Vascular Endothelial Growth Factor (Vegf) Concentration in the Serum and Follicular Fluid of Women With Pcos Undergoing Icsi/Ivf.

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