2022
DOI: 10.1016/j.jacadv.2022.100008
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Placental Findings in Pregnancies Complicated by Maternal Cardiovascular Disease

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Cited by 10 publications
(15 citation statements)
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“…Additionally, Wu et al found that placentas from pregnancies complicated by maternal CHD, arrhythmia, cardiomyopathy, connective tissue disease, acquired valvular disease, ischemic heart disease, or vascular disease commonly showed evidence of vascular abnormalities 4 . Within the maternal CHD cohort, Wu et al found no differences in anatomic, infectious, in ammatory, or vascular pathology based on anatomic or physiologic classi cation of CHD 4 . Our study similarly found high rates of maternal vascular malperfusion in pregnancies affected by maternal CHD, though no differences were seen in rates of histopathologic evidence of maternal vascular malperfusion based on cardiovascular risk.…”
Section: Discussionmentioning
confidence: 99%
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“…Additionally, Wu et al found that placentas from pregnancies complicated by maternal CHD, arrhythmia, cardiomyopathy, connective tissue disease, acquired valvular disease, ischemic heart disease, or vascular disease commonly showed evidence of vascular abnormalities 4 . Within the maternal CHD cohort, Wu et al found no differences in anatomic, infectious, in ammatory, or vascular pathology based on anatomic or physiologic classi cation of CHD 4 . Our study similarly found high rates of maternal vascular malperfusion in pregnancies affected by maternal CHD, though no differences were seen in rates of histopathologic evidence of maternal vascular malperfusion based on cardiovascular risk.…”
Section: Discussionmentioning
confidence: 99%
“…Howell et al showed that maternal obesity results in downregulation of placental VEGF/Flt signaling resulting in decreased placental angiogenesis, placental hypoperfusion, and increased risk for pregnancy complications like SGA and pre-eclampsia 9 . Additionally, Wu et al found that placentas from pregnancies complicated by maternal CHD, arrhythmia, cardiomyopathy, connective tissue disease, acquired valvular disease, ischemic heart disease, or vascular disease commonly showed evidence of vascular abnormalities 4 . Within the maternal CHD cohort, Wu et al found no differences in anatomic, infectious, in ammatory, or vascular pathology based on anatomic or physiologic classi cation of CHD 4 .…”
Section: Discussionmentioning
confidence: 99%
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“…Additionally, maternal CHD is associated with adverse pregnancy and neonatal outcomes, such as higher rates of preterm birth, small for gestational age (SGA) birth weights, and neonatal mortality 2 , 3 . Although it remains unclear what mediates the relationship between maternal CHD and these adverse pregnancy and neonatal outcomes, it is biologically plausible that altered placental development and function, as a conduit of the feto-maternal system, drive these outcomes 4 .…”
Section: Introductionmentioning
confidence: 99%