Placental Growth Factor Level is Lower in Early-Onset Preeclampsia, while Tumor Necrosis Factor Alpha Level does not Show any Difference between Early and Late Onset Preeclampsia

Abstract

Objective: To analyze the difference of PlGF and TNF-α serum level between early-onset and late-onset preeclampsia.
 
 Method: This is a cross-sectional analytic comparative study comparing serum level of PlGF and TNF-α between groups with earlyand late-onset preeclampsia. Each group consists of 32 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital or its district hospitals in September - November 2012. Statistical analysis was performed with Kolmogorov Smirnov test, Saphiro-Wilk test, and non-parametric Mann-Whitney test.
 
 Result: Mean of PlGF serum level in the group with early-onset preeclampsia is 53.0344±38.07140 pg/ml, while mean of which in the group with late-onset preeclampsia is 241.8063±192.8373 pg/ml (p

Differences in levelFms-Like Tyrosine Kinase-1 (sFlt-1), soluble Endoglin (s-Eng), and Placental Growth Factor (PIGF) between Early Onset Preeclampsia and Late Onset Preeclampsia

“…Conclusions from several studies on antiangiogenic and angiogenic biomarkers by Villa, et al (2013) andRahmiLaila, et al (2016) regarding sFlt-1, is that serum levels of sFlt-1 in early onset PE are higher than late onset PE. The results of the study by Akbar, et al, (2017) found that soluble endoglin (sEng) serum levels were significantly higher in early onset PE compared to late onset PE (47.65 ± 40.17 vs 13.46 ± 9.48), while the mean serum PIGF in the early onset PE group (53.03 ± 38.07 pg / mL) was lower than late onset PE (241.80 ± 192.83 pg / mL) with p <0.0001 (Ekapatria, et al, 2012).…”