Placental, hepatic, and supraclavicular lymph node metastasis in pancreatic adenocarcinoma during pregnancy: A case report

Abstract

The occurrence of coexisting cancer in pregnant women is not a common phenomenon. It complicates approximately 1 in 1000 to 1500 pregnancies. We present a multiparous woman aged 27 years in her 28th week of pregnancy who was admitted to our clinic with right upper quadrant pain and was finally revealed to have multiple metastatic pancreatic adenocarcinoma. To the best of our knowledge, this is the first documented case of pancreatic adenocarcinoma to metastasize both to the placenta and multiple maternal sites (liver, supraclavicular, para-aortic lymph nodes) in a pregnant patient. Unpredictable metastases to the placenta may be encountered and may even lead to definitive diagnosis, as in our case. Therefore, the placenta in any patient with known malignancy should be sent for pathologic evaluation.

Challenges in the management of adenocarcinoma of ampulla of Vater in pregnancy: A case report and review of literature

“… Tica et al [ 39 ] MCN 27 abnormal sonogram 3rd (29) MRI postpartum No complications Huang et al [ 40 ] SPNs 29 Epigastric pain, backache, nausea, and vomiting 2nd (19) US, MRI 2nd (19) Tumor rupture MacDonald et al [ 41 ] SPNs 23 Incidentally abdominal mass by US 2nd (14) US, MRI 2nd (18) No complications Labarca-Acosta et al [ 42 ] Adenocarcinoma 35 Vomiting, pain in the left epigastrium and hypochondrium, general weakness and weight loss. 16 weeks Fine-needle biopsy – Maternal death Aker et al [ 43 ] Adenocarcinoma 27 Right upper quadrant pain, nausea,and vomiting. 2nd (26) ascites cytology Post-partum Fetal death Metastasis to placenta, hepatic, supraclavicular lymph node Davis et al [ 44 ] Adenocarcinoma 34 abdominal pain and failure to gain weight appropriately in pregnancy.…”