Placental hypoxia inducible factor -1α &amp; CHOP immuno-histochemical expression relative to maternal circulatory syncytiotrophoblast micro-vesicles in preeclamptic and normotensive pregnancies

Verma, S.; Pillay, Preenan; Naicker, Thajasvarie; Moodley, Jagidesa; Mackraj, Irene

doi:10.1016/j.ejogrb.2017.11.004

Cited by 28 publications

(24 citation statements)

References 24 publications

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“…Larger cell debris is also released by the placenta, which includes nuclear aggregates and apoptotic bodies (20–500 µm and 1–4 µm, respectively). These events also occur and are most likely enhanced in the context of PE, as recently shown by Verma et al [ 25 ].…”

Section: Cellular Sources Of Oxidative Stress In the Human Placentmentioning

confidence: 58%

Oxidative Stress in Preeclampsia and Placental Diseases

Aouache

Biquard

Vaiman

et al. 2018

IJMS

433

259

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Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.

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Section: Cellular Sources Of Oxidative Stress In the Human Placentmentioning

confidence: 58%

Oxidative Stress in Preeclampsia and Placental Diseases

Aouache

Biquard

Vaiman

et al. 2018

IJMS

433

259

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“…Recently, ENDOU has been reported to play a role in increased CCAAT-enhancer-binding protein homologous protein (CHOP) protein levels upon stress, (34) and CHOP expression was reported to be upregulated in PE and PE-FGR placentas. (35,36) These findings suggest that ENDOU might be related to the pathogenesis of PE-FGR placentas, although further investigation is needed.…”

Section: Discussionmentioning

confidence: 90%

Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction

Nomoto

Kotani

Miki

et al. 2021

J. Clin. Biochem. Nutr.

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Placental hypoplasia is associated with the pathophysiology of fetal growth restriction and preeclampsia. The placenta consists of differentiated trophoblasts, including cytotrophoblasts, syncytiotrophoblasts, and extravillous trophoblasts. Cytotrophoblasts are thought to have stem-like characteristics and the ability to differentiate into syncytiotrophoblasts and extravillous trophoblasts. However, it is poorly understood whether isolated cytotrophoblasts derived from hypoplastic placentas have specific features compared with those in normal placentas. This study aimed to determine the features of cytotrophoblasts in hypoplastic placentas. Differentially expressed proteins between isolated cytotrophoblasts from hypoplastic placenta with fetal growth restriction and those from the normal placenta were determined by liquid chromatography-tandem mass spectrometry. Among 6,802 proteins, 1,253 and 2,129 proteins were more than 2-fold upregulated and downregulated, respectively. Among them, ENDOU (endonuclease, poly(U) specific), which has high homology with the coronavirus endoribonuclease nonstructural protein 15 (Nsp15), showed a significantly increased expression in cytotrophoblasts from the placenta with fetal growth restriction related to preeclampsia compared with those in normal control placenta. These results provide insight into the pathological mechanisms of placental hypoplasia and additional information on preeclamptic symptoms in cases of SARS-CoV-2 infected placenta, although further investigation is needed.

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“…Standardized sampling in fasting subjects is to be preferred. [32][33][34] Some studies are underpowered; few contain a power calculation. 21,35 There is consensus that both small and medium-large STBEV release in EOPE is greater in women with PE than gestation-matched controls; most studies report that total plasma EV release is also increased.…”

Section: Stbev Release In Pementioning

confidence: 99%

Syncytiotrophoblast Derived Extracellular Vesicles in Relation to Preeclampsia

Cooke¹,

Jones²,

Redman³

et al. 2021

Maternal-Fetal Medicine

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The syncytiotrophoblast, a fused single-cell layer between mother and fetus, constitutively releases extracellular vesicles (STBEV) directly into the maternal circulation. STBEV contain a variety of proteins and RNA which can be targeted to specific cells. In preeclampsia, asymptomatic placental oxidative stress is a precursor to later multi-organ dysfunction in the mother. Increased STBEV release in pre-eclampsiasia is considered a manifestation of syncytiotrophoblast stress, which may play a key role in signaling between fetus and mother. STBEV release in pre-eclampsia changes, both in terms of volume and content. In this review, we outline the latest advances in STBEV isolation and detection. We consider evidence for differential STBEV release, protein cargo and RNA content in pre-eclampsia, highlighting common pitfalls in study design. We summarise studies to date demonstrating STBEV actions on target cells. Ultimately, we consider how STBEV fit into the pathophysiology of the heterogeneous syndrome of pre-eclampsia.The key unifying concept in early-and late-onset pre-eclampsia is syncytiotrophoblast stress. We submit that STBEV are the key stress signal in pre-eclampsia. We believe that further investigation of STBEV release, content, and actions may offer valuable insights into pre-eclampsia pathophysiology and potential new clinical diagnostics and therapeutic targets.

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Placental hypoxia inducible factor -1α & CHOP immuno-histochemical expression relative to maternal circulatory syncytiotrophoblast micro-vesicles in preeclamptic and normotensive pregnancies

Cited by 28 publications

References 24 publications

Oxidative Stress in Preeclampsia and Placental Diseases

Oxidative Stress in Preeclampsia and Placental Diseases

Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction

Syncytiotrophoblast Derived Extracellular Vesicles in Relation to Preeclampsia

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