Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

Xu, Xijin; Yekeen, Taofeek A.; Xiao, Qiongna; Wang, Yuangping; Lu, Fangfang; Huo, Xia

doi:10.1016/j.envpol.2013.07.005

Cited by 71 publications

(42 citation statements)

References 39 publications

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“…Growth hormones, such as placental insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) from an e-waste-exposed area, were higher than those from the reference group. This result shows that IGF-1 and IGFBP-3 can be used as monitoring indicators of fetal intrauterine growth and development [34]. Children are susceptible to environmental pollution, and their normal growth and development are disturbed when they are exposed to harmful substances.…”

Section: Developmental Toxicitymentioning

confidence: 96%

E-waste environmental contamination and harm to public health in China

Zeng

Boezen

et al. 2015

Front. Med.

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The adverse effects of electronic waste (e-waste) on the human body have stirred up concern in recent years. China is one of the countries that confront serious pollution and human exposure of e-waste, and the majority of the population is exposed to potentially hazardous substances that are derived from informal e-waste recycling processes. This study reviews recent reports on human exposure to e-waste in China, with particular focus on exposure routes (e.g., inhalation and ingestion) and several toxicities of human (e.g., endocrine system, respiratory system, reproductive system, developmental toxicity, neurotoxicity, and genetic toxicity). Pieces of evidence that associate e-waste exposure with human health effects in China are assessed. The role of toxic heavy metals (e.g., lead, cadmium, chromium, mercury, and nickel) and organic pollutants (e.g., polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyl (PCBs), polycyclic aromatic hydrocarbons (PAHs), polybrominated biphenyls (PBBs), polyhalogenated aromatic hydrocarbons (PHAHs), bisphenol A (BPA)) on human health is also briefly discussed.

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Section: Developmental Toxicitymentioning

confidence: 96%

E-waste environmental contamination and harm to public health in China

Zeng

Boezen

et al. 2015

Front. Med.

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“…Guiyu has a total area of 52 km 2 and a population of 150,000 (Bi et al, 2010;Alabi et al, 2012;Ren et al, 2013;Xu et al, 2013;Liu et al, 2014). It is a rice-growing countryside and its industry has been dominated by e-waste recycling since the early 1980s.…”

Section: Sampling Sitesmentioning

confidence: 99%

Ambient Air Heavy Metals in PM2.5 and Potential Human Health Risk Assessment in an Informal Electronic-Waste Recycling Site of China

Zheng

Yekeen

et al. 2016

Aerosol Air Qual. Res.

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108

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In this study, we characterized the concentration of heavy metals in PM 2.5 in the community with e-waste dismantling, Guiyu, China and assessed potential public health risk associated with heavy metal composition of PM 2.5 for local residents. Daily samples of PM 2.5 were collected with Harvard Impactors on the roof of 3-story buildings from March 2012-April 2013 in Guiyu (n = 133) and seasonal samples were collected in a reference site, Haojiang (n = 33). The concentrations of PM 2.5 mass and heavy metals were analyzed gravimetrically and by graphite furnace atomic absorption spectrometry, respectively. The geometric mean concentrations of PM 2.5 , Pb and Cd in Guiyu were higher than in the reference area (PM 2.5 : 49.9 µg m -3 vs. 37.6 , p < 0.01; Pb: 160 ng m -3 vs. 69 ng m vs. 16 ng m -3 , p > 0.05). The metal concentrations in PM 2.5 from Guiyu were also higher when compared to other Asian cities. We observed higher heavy metal concentrations during winter and spring than summer and fall. Human health risk assessment showed that the total potential cancer risk for both adults and children are higher than the safe acceptable range recommended by the US EPA. Furthermore, the carcinogenic and non-carcinogenic elements in PM 2.5 pose higher public health risk to children than adults. The results indicate that air pollution emitted from informal e-waste recycling activities might be affecting the health of local residents, especially children.

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“…Compared with other sites from Nigeria or China, higher levels of PBDE are found in soil, air, sediment, as well as freshwater fish collected from Guiyu [7,8]. PBDE concentrations in umbilical cord blood are also higher than those from nearby reference areas without e-waste recycling activities [4,9]. The metabolites and environmental derivatives of PBDE have a similar chemical structure as thyroid hormones (TH), especially for thyroxine (T4) [10,11].…”

Section: Introductionmentioning

confidence: 89%

“…A study shows that PBDEs may mimic or compete with TH to disrupt the function of target organs [12]. In addition, epidemiological studies suggest that occupational and environmental exposure to persistent organic pollutants (POPs) might alter insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) levels or their gene expression, which are involved in the insulin-like growth factor (IGF) axis when impact on growth and development [4,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Guiyu, a town with a total area of 52 km 2 and a population of 139,000 (2010) located in Shantou, China, is one of the largest e-waste destinations in the world. More than 6,000 small-scale family-run workshops and nearly 160,000 workers (including approximately 100,000 migrant farmer laborers) are involved in the business of e-waste dismantling and recycling with crude and uncontrolled methods that extensively introduce environmental pollutants into the community [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated Serum Polybrominated Diphenyl Ethers and Alteration of Thyroid Hormones in Children from Guiyu, China

Liu¹

2012

Sixth International Conference on Environmental Mutagens in Human Populations

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Informal electronic waste (e-waste) recycling results in serious environmental pollution of polybrominated diphenyl ethers (PBDEs) and heavy metals. This study explored whether there is an association between PBDEs, heavy metal and key growth-and development-related hormones in children from Guiyu, an e-waste area in southern China. We quantified eight PBDE congeners using gas chromatographic mass spectrometry, lead and cadmium utilizing graphite furnace atomic absorption spectrometry, three thyroids with radioimmunoassay and two types of growth hormones by an enzyme-linked immune-sorbent assay (ELISA) in 162 children, 4 to 6 years old, from Guiyu. In blood, median total PBDE was 189.99 ng/g lipid. Lead and cadmium concentrations in blood averaged 14.53¡4.85 mg dL 21 and 0.77¡0.35 mg L 21 , respectively. Spearman partial correlation analysis illustrated that lead was positively correlated with BDE153 and BDE183. Thyroid-stimulating hormone (TSH) was positively correlated with almost all PBDE congeners and negatively correlated with insulin-like growth factor binding protein-3 (IGFBP-3), whereas free triiodothyronine (FT3) and free thyroxine (FT4) were negatively correlated with BDE154. However, no correlation between the hormones and blood lead or cadmium levels was found in this study. Adjusted multiple linear regression analysis showed that total PBDEs was negatively associated with FT3 and positively associated with TSH. Notably, FT4 was positively correlated with FT3, house functions as a workshop, and father's work involved in e-waste recycling and negatively correlated with vitamin consumptions.

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Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

Cited by 71 publications

References 39 publications

E-waste environmental contamination and harm to public health in China

E-waste environmental contamination and harm to public health in China

Ambient Air Heavy Metals in PM2.5 and Potential Human Health Risk Assessment in an Informal Electronic-Waste Recycling Site of China

Elevated Serum Polybrominated Diphenyl Ethers and Alteration of Thyroid Hormones in Children from Guiyu, China

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