Placental Inflammatory Response Is Associated With Poor Neonatal Growth: Preterm Birth Cohort Study

Mestan, Karen K.; Yu, Yunxian; Matoba, Nana; Cerda, Sandra; Demmin, Bethany; Pearson, Colleen; Ortiz, Katherin; Wang, Xiaobin

doi:10.1542/peds.2009-0313

Cited by 70 publications

(63 citation statements)

References 30 publications

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“…The authors speculated that release of cytokines and other vasoactive substances in the setting of intrauterine infection might cause vasospasm and alter blood flow to the fetus. Other studies with far smaller sample sizes do not support this finding [103,108] . Recently, a significant association of histological chorioamnionitis with poor early postnatal growth could be demonstrated in a cohort of 256 preterm infants [108] .…”

Section: Chorioamnionitis Fetal Growth Restriction and Poor Neonatalmentioning

confidence: 72%

Chorioamnionitis: Important Risk Factor or Innocent Bystander for Neonatal Outcome?

2010

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Chorioamnionitis as a major risk factor for spontaneous preterm birth, especially at earlier gestational ages, contributes to prematurity-associated mortality and morbidity. A gestation-independent effect of chorioamnionitis on neonatal outcome is much more difficult to assess. The influence of chorioamnionitis on neonatal outcome has become less evident with advances in neonatal care. A short-term beneficial effect of histological, but not clinical chorioamnionitis on incidence and severity of respiratory distress syndrome in preterm infants is evident. This maturational effect is accompanied by a susceptibility of the lung for further postnatal injury, which predisposes for bronchopulmonary dysplasia. Chorioamnionitis is associated with cystic periventricular leukomalacia, intraventricular hemorrhage and cerebral palsy in preterm infants, but its association with noncystic white matter disease is not clear yet. Prenatal inflammation/infection has been shown a risk factor for neonatal sepsis. A single course of antenatal steroids can be regarded safe in clinical as well as histological chorioamnionitis.

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Section: Chorioamnionitis Fetal Growth Restriction and Poor Neonatalmentioning

confidence: 72%

Chorioamnionitis: Important Risk Factor or Innocent Bystander for Neonatal Outcome?

2010

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“…Measures of postnatal growth failure, also referred to as extrauterine growth restriction or extrauterine 7,[29][30][31] at the time of hospital discharge, 32,33 or at 28 days after birth. 34 Measures based on z scores at discharge and the differences between these scores at birth and discharge have also been used.…”

Section: Discussionmentioning

confidence: 99%

Weight Growth Velocity and Postnatal Growth Failure in Infants 501 to 1500 Grams: 2000–2013

et al. 2015

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BACKGROUND: Very low birth weight infants often gain weight poorly and demonstrate growth failure during the initial hospitalization. Although many of the major morbidities experienced by these infants during their initial NICU stays have decreased in recent years, it is unclear whether growth has improved. METHODS: We studied 362 833 infants weighing 501 to 1500 g without major birth defects born from 2000 to 2013 and who were hospitalized for 15 to 175 days at 736 North American hospitals in the Vermont Oxford Network. Average growth velocity (GV; g/kg per day) was computed by using a 2-point exponential model on the basis of birth weight and discharge weight. Postnatal growth failure and severe postnatal growth failure were defined as a discharge weight less than the 10th and third percentiles for postmenstrual age, respectively. RESULTS: From 2000 to 2013, average GV increased from 11.8 to 12.9 g/kg per day. Postnatal growth failure decreased from 64.5% to 50.3% and severe postnatal growth failure from 39.8% to 27.5%. The interquartile ranges for the hospitals participating in 2013 were as follows: GV, 12.3 to 13.4 g/kg per day; postnatal growth failure, 41.1% to 61.7%; and severe postnatal growth failure, 19.4% to 36.0%. Adjusted and unadjusted estimates were nearly identical. CONCLUSIONS: For infants weighing 501 to 1500 g at birth, average GV increased and the percentage with postnatal growth failure decreased. However, in 2013, half of these infants still demonstrated postnatal growth failure and one-quarter demonstrated severe postnatal growth failure.

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“…In human studies, chorioamnionitis has been associated with neonatal death (27,86), early-onset neonatal sepsis (86)(87)(88), intrauterine growth restriction (89), poor neonatal growth (90), neurologic impairment/injury (91,92), intraventricular hemorrhage (86), bronchopulmonary dysplasia (93)(94)(95), patent ductus arteriosus (86,89,93,96), retinopathy of prematurity (89,97,98), cardiovascular abnormalities (99, 100), necrotizing enterocolitis (101,102), and dermatitis (103). However, low gestational age is often a significant contributing factor (104)(105)(106), and therefore, it is difficult to attribute these sequelae solely to chorioamnionitis.…”

Section: Neonatal Sequelae Of Chorioamnionitismentioning

confidence: 99%

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

et al. 2017

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SUMMARY The human Ureaplasma species are the most frequently isolated microorganisms from the amniotic fluid and placentae of women who deliver preterm and are also associated with spontaneous abortions or miscarriages, neonatal respiratory diseases, and chorioamnionitis. Despite the fact that these microorganisms have been habitually found within placentae of pregnancies with chorioamnionitis, the role of Ureaplasma species as a causative agent has not been satisfactorily explained. There is also controversy surrounding their role in disease, particularly as not all women infected with Ureaplasma spp. develop chorioamnionitis. In this review, we provide evidence that Ureaplasma spp. are associated with diseases of pregnancy and discuss recent findings which demonstrate that Ureaplasma spp. are associated with chorioamnionitis, regardless of gestational age at the time of delivery. Here, we also discuss the proposed major virulence factors of Ureaplasma spp., with a focus on the multiple-banded antigen (MBA), which may facilitate modulation/alteration of the host immune response and potentially explain why only subpopulations of infected women experience adverse pregnancy outcomes. The information presented within this review confirms that Ureaplasma spp. are not simply “innocent bystanders” in disease and highlights that these microorganisms are an often underestimated pathogen of pregnancy.

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Placental Inflammatory Response Is Associated With Poor Neonatal Growth: Preterm Birth Cohort Study

Abstract: Placental inflammation is associated with poor neonatal growth. MIR and FIR may be useful markers for identifying infants at risk for postnatal growth failure.

Cited by 70 publications

References 30 publications

Chorioamnionitis: Important Risk Factor or Innocent Bystander for Neonatal Outcome?

Chorioamnionitis: Important Risk Factor or Innocent Bystander for Neonatal Outcome?

Weight Growth Velocity and Postnatal Growth Failure in Infants 501 to 1500 Grams: 2000–2013

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

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