2005
DOI: 10.1016/j.ygyno.2005.03.043
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Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia

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Cited by 32 publications
(30 citation statements)
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“…Thus, the results here presented are novel and may shed some light onto the metabolic alterations occurring in this type of cancer. Indeed, the upregulation of glycolytic enzymes in ovarian cancer [3941] points to an increased production of lactate and, consequently, to the need for upregulation of lactate transport. In harmony with this line of evidence, we found a relevant MCT1 expression in ovarian carcinoma, which warrants further studies on MCT expression in this type of carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the results here presented are novel and may shed some light onto the metabolic alterations occurring in this type of cancer. Indeed, the upregulation of glycolytic enzymes in ovarian cancer [3941] points to an increased production of lactate and, consequently, to the need for upregulation of lactate transport. In harmony with this line of evidence, we found a relevant MCT1 expression in ovarian carcinoma, which warrants further studies on MCT expression in this type of carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…The high-affinity GLUT1 is ubiquitously expressed and responsible for basal cellular glucose uptake. GLUT1 and GLUT4 are frequently overexpressed on cancer cells [12][13][14], facilitating increased glucose uptake.…”
Section: Role Of Glucose and Insulin In Cancer Development And Growthmentioning
confidence: 99%
“…Recently it was shown that the expression of APN in 194 patients with non-small cell lung cancer was associated with increased angiogenesis and poor prognosis [24]. Surowiak et al [25] have shown that APN is present in ovarian cancers, with an elevated expression in specimens unexposed to chemotherapy and Shibata et al [26] have demonstrated an increase in LAP expression in invasive ovarian carcinoma compared to benign and borderline tumors. A recent study by Yamashita et al [27] showed direct involvement of APN in the sensitivity of ten ovarian carcinoma cell lines against paclitaxel, suggesting it to be a target in combination therapy regimens.…”
Section: Discussionmentioning
confidence: 99%