Placental macrophage (Hofbauer cell) polarization is independent of maternal allergen-sensitization and presence of chorioamnionitis

Joerink, Maaike; Rindsjö, Erika; Riel, B. van; Alm, Johan; Papadogiannakis, Nikos

doi:10.1016/j.placenta.2011.02.003

Cited by 76 publications

(78 citation statements)

References 36 publications

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“…Our data also showed that conditioned medium from isolated CTB and EVT cells could induce the phenotype of decidual macrophages and the expansion of Treg cells (Bockle et al, 2008;Joerink et al, 2011). (King et al, 2000c;Apps et al, 2009;Morales-Prieto et al, 2012).…”

Section: Macrophages Th Cells and Treg Cellssupporting

confidence: 67%

Immune regulation at the fetal‐maternal interface with focus on decidual macrophages

Svensson‐Arvelund¹

2015

Linköping University Medical Dissertations

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A successful pregnancy requires that the maternal immune system adapts to tolerate the semi-allogeneic fetal-placental unit. This adaptation mainly occurs locally, i.e. at the fetal-maternal interface, where fetal-derived tissues come into close contact with maternal cells in the uterine endometrium (called decidua during pregnancy). decidual macrophages preferentially secreted the monocyte-and Treg cell-associated chemokines CCL2 and CCL18, while Th1-, Th2-and Th17-related chemokines were produced at low levels. These results suggest that decidual macrophages contribute to create the unique decidual cell composition and a tolerogenic immune environment that is compatible with fetal development. Further, by comparing decidual macrophages with different in vitro macrophage subsets, we showed that M-CSF and

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Section: Macrophages Th Cells and Treg Cellssupporting

confidence: 67%

Immune regulation at the fetal‐maternal interface with focus on decidual macrophages

Svensson‐Arvelund¹

2015

Linköping University Medical Dissertations

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“…CD163 was also shown to be expressed by M-CSF-differentiated macrophages, which mimic first-trimester pMw (41). Furthermore, CD163 has been associated with macrophage polarization (42), and the notion of pMw M2 polarization has been largely based on this expression (41,43).…”

Section: Discussionmentioning

confidence: 97%

Placental Macrophages Are Impaired in Chorioamnionitis, an Infectious Pathology of the Placenta

Amara

Gorvel

Baulan

et al. 2013

The Journal of Immunology

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Pregnancy is dependent on maternal–fetal tolerance that may be compromised because of infections or inflammation of the placenta. In this study, we examined whether the context of placental immune tolerance affected the functions of resident macrophages and if their functions were altered during chorioamnionitis, an infectious pathology of the placenta. Macrophages from at-term placentas expressed CD14, exhibited macrophage microbicidal functions, but were less inflammatory than monocyte-derived macrophages. Moreover, placental macrophages spontaneously matured into multinucleated giant cells (MGCs), a property not exhibited by monocyte-derived macrophages, and we detected MGCs of myeloid origin in placental tissue. Compared with placental macrophages, MGCs exhibited a specific phenotype and gene expression signature, consisting of increased cytoskeleton-associated gene expression along with depressed expression of inflammatory response genes. Furthermore, placental macrophages from patients with chorioamnionitis were unable to form MGCs, but this defect was partially corrected by incubating these placental macrophages with control trophoblast supernatants. MGCs formation likely serves to regulate their inflammatory and cytocidal activities in a context that imposes semiallograft acceptance and defense against pathogens.

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“…31,32 Hofbauer cells have many histologic features of macrophages in other organs-they are large (10-30-lm diameter) cells with cytoplasmic processes, and contain large vacuoles, pinocytotic vesicles, and intracytoplasmic granules. They have been characterized as M2/alternatively activated macrophages, 33 and their function includes phagocytosis of fluids and apoptotic materials, antigen presentation in response to infectious agents, and possibly an angiogenic role in early placental vasculogenesis, maintenance of placental water balance, and an endocrine function. Because Hofbauer cells can vary in size and shape, they can easily be confused with mononuclear inflammatory cells, and especially plasma cells, leading to an erroneous diagnosis of chronic lymphocytic or plasmacellular villitis (Figure 1, C).…”

Section: Discussionmentioning

confidence: 99%

Placental Pathology of Zika Virus: Viral Infection of the Placenta Induces Villous Stromal Macrophage (Hofbauer Cell) Proliferation and Hyperplasia

Rosenberg¹,

Yu²,

Hill³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

161

151

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Context.-The placenta is an important component in understanding the fetal response to intrauterine Zika virus infection, but the pathologic changes in this organ remain largely unknown. Hofbauer cells are fetal-derived macrophages normally present in the chorionic villous stroma. They have been implicated in a variety of physiological and pathologic processes, in particular involving infectious agents.Objectives.-To characterize the fetal and maternal responses and viral localization in the placenta following Zika virus transmission to an 11 weeks' gestation fetus. The clinical course was notable for prolonged viremia in the mother and extensive neuronal necrosis in the fetus. The fetus was delivered at 21 weeks' gestation after pregnancy termination.Design.-The placenta was evaluated by using immunohistochemistry for inflammatory cells (macrophages/ monocytes [Hofbauer cells], B and T lymphocytes) and proliferating cells, and an RNA probe to Zika virus. The fetal brain and the placenta were previously found to be positive for Zika virus RNA by reverse transcriptionpolymerase chain reaction.Results.-The placenta demonstrated prominently enlarged, hydropic chorionic villi with hyperplasia and focal proliferation of Hofbauer cells. The degree of Hofbauer cell hyperplasia gave an exaggerated immature appearance to the villi. No acute or chronic villitis, villous necrosis, remote necroinflammatory abnormalities, chorioamnionitis, funisitis, or hemorrhages were present. An RNA probe to Zika virus was positive in villous stromal cells, presumably Hofbauer cells.Conclusions.-Zika virus placental infection induces proliferation and prominent hyperplasia of Hofbauer cells in the chorionic villi but does not elicit villous necrosis or a maternal or fetal lymphoplasmacellular or acute inflammatory cell reaction.

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Placental macrophage (Hofbauer cell) polarization is independent of maternal allergen-sensitization and presence of chorioamnionitis

Cited by 76 publications

References 36 publications

Immune regulation at the fetal‐maternal interface with focus on decidual macrophages

Immune regulation at the fetal‐maternal interface with focus on decidual macrophages

Placental Macrophages Are Impaired in Chorioamnionitis, an Infectious Pathology of the Placenta

Placental Pathology of Zika Virus: Viral Infection of the Placenta Induces Villous Stromal Macrophage (Hofbauer Cell) Proliferation and Hyperplasia

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