Placental Malaria and the Risk of Malaria in Infants in a High Malaria Transmission Area in Ghana: A Prospective Cohort Study

Asante, Kwaku Poku; Owusu‐Agyei, Seth; Cairns, Matthew; Dodoo, Daniel; Boamah, Ellen Abrafi; Gyasi, Richard K.; Adjei, George; Gyan, Ben; Agyeman-Budu, Akua; Dodoo, Theophilus; Mahama, Emmanuel; Amoako, Nicholas; Dosoo, David; Koram, Kwadwo A.; Greenwood, Brian; Chandramohan, Daniel

doi:10.1093/infdis/jit366

Cited by 47 publications

(80 citation statements)

References 27 publications

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“…However, as reported from the Kintampo Birth Cohort Study conducted in 2010, ITN use among women in the study area was low, 47% [19]. In a previous study conducted in Nigeria in 2012 [20], knowledge about the usefulness of ITNs in preventing malaria and the risk of malaria in pregnancy was concluded as the most likely factor required to increase ITN use.…”

Section: Discussionmentioning

confidence: 92%

“…Malaria parasite prevalence among children below 5 years of age in the study area was about 50% in 2009 and the entomological inoculation rate was about 269 infective bites per person per year [18]. A birth cohort study conducted in 2010 in the study area showed that the prevalence of placental malaria was about 40% [19]. …”

Section: Methodsmentioning

confidence: 99%

“…In the Kintampo study, pregnant women were enrolled into the study and followed up monthly till delivery. During follow-up visits, they were asked whether they slept under an insecticide-treated net the night before the visit in addition to other questions as described elsewhere [19]. Women who did not sleep under ITNs the night before the visit on two or more occasions were purposively selected for this study.…”

Section: Methodsmentioning

confidence: 99%

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Low Utilization of Insecticide-Treated Bed Net among Pregnant Women in the Middle Belt of Ghana

Manu

Boamah-Kaali

Febir

et al. 2017

Malaria Research and Treatment

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Background Malaria in pregnancy leads to low birth weight, premature birth, anaemia, and maternal and neonatal mortality. Use of insecticide-treated nets (ITNs) during pregnancy is one of the proven interventions to reduce the malaria burden. However, Ghana has not achieved its target for ITN use among pregnant women. Methods A qualitative study was conducted in seven communities purposively selected from the middle belt of Ghana. Participants who had delivered in the six months prior to this study were selected. In all, seven focus group discussions and twenty-four in-depth interviews were conducted between June and August 2010. Results Respondents knew of the importance of ITNs and other malaria-preventive strategies. Factors such as financial access and missed opportunities of free distribution denied some pregnant women the opportunity to own or use an ITN. Reasons for not using ITNs during pregnancy included discomfort resulting from heat, smell of the net, and difficulty in hanging the net. Participants maintained their ITNs by preventing holes in the nets, retreatment, and infrequent washing. Conclusion Pregnant women know about the causes and prevention of malaria. However, this knowledge is not transformed into practice due to lack of access to ITNs and sleeping discomforts among other logistical constraints.

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Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Low Utilization of Insecticide-Treated Bed Net among Pregnant Women in the Middle Belt of Ghana

Manu

Boamah-Kaali

Febir

et al. 2017

Malaria Research and Treatment

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“…37 Not at last, MiPexposure is associated with an increased risk of malaria during infancy, 38 which is partly attributed to familial socioeconomic status. 39 Still, cumulative effects of early-life exposure to malaria on the metabolic health in adult age are conceivable.…”

Section: Direct Effects Of Exposure To Mip On Metabolic Traitsmentioning

confidence: 99%

In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study

Bedu-Addo

Alicke

Boakye-Appiah

et al. 2017

Journal of Infection

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Summary Objectives: Malaria in pregnancy (MiP) contributes to fetal undernutrition and adverse birth outcomes, and may constitute a developmental origin of metabolic diseases in the offspring. In a Ghanaian birth cohort, we examined the relationships between MiP-exposure and metabolic traits in adolescence.Methods: MiP at delivery was assessed in 155 mother-child pairs. Among the now teenaged children (mean age, 14.8 years; 53% male), we measured fasting plasma glucose (FPG), body mass index (BMI), and systolic and diastolic blood pressure (BP). Associations of MiP with the adolescents' FPG, BMI, and BP were examined by linear regression.Results: At delivery, 45% were MiP-exposed, which increased FPG in adolescence, adjusted for mother's age at delivery, parity and familial socio-economic status (infected vs. uninfected: mean ΔFPG = 0.20 mmol/L; 95% confidence interval (CI): 0.01, 0.39; p = 0.049). As a trend, this was discernible for BP, particularly for microscopic infections (mean Δsystolic BP = 5.43 mmHg; 95% CI: 0.00, 10.88; p = 0.050; mean Δdiastolic BP = 3.67 mmHg; 95% CI: −0.81, 8.14; p = 0.107). These associations were largely independent of birth weight, gestational age and teenage BMI. Adolescent BMI was not related to MiP. Conclusions:In rural Ghana, exposure to malaria during fetal development contributes to metabolic conditions in young adulthood.

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“…Malaria and respiratory infections are among the top ten diseases reported at health facilities(KNMA, 2013). There is significant poor ill-health among new-borns and infants; low birth weight prevalence is about 10% (Asante et al, 2013), neonatal mortality is 32/1000 live-birth, and infant mortality is 64/1000 child years (Kirkwood et al, 2010a). Health care is basic in the study area and the first point of call for an acute illness is a local chemical shop (Asante et al, 2010).…”

Section: Study Areamentioning

confidence: 99%

Childhood Respiratory Morbidity and Cooking Practices Among Households in a Predominantly Rural Area of Ghana

Asante¹,

Kinney²,

Zandoh³

et al. 2016

AJID

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Background: Household air pollution is a leading risk factor for respiratory morbidity and mortality in developing countries where biomass fuel is mainly used for cooking. Materials and Method: A household cross-sectional survey was conducted in a predominantly rural area of Ghana in 2007 to determine the prevalence of respiratory symptoms and their associated risk factors. Household cooking practices were also assessed as part of the survey. Results: Household heads of twelve thousand, three hundred and thirty-three households were interviewed. Fifty-seven percent (7006/12333) of these households had at least one child less than five years of age. The prevalence of symptoms of acute lower respiratory infections (ALRI) was 13.7% (n= 957, 95% CI 12.8 -15.5%). A majority (77.8%, 95% CI, 77.7 -78.5%) of households used wood as their primary fuel. Majority of respondents who used wood as their primary fuel obtained them by gathering wood from their neighborhood (95.6%, 9177/9595) and used a 3-stone local stove for cooking (94.9%, 9101/9595). In a randomly selected subset of respondents, females were the persons who mostly gathered firewood from the fields (90.8%, 296/326) and did the cooking (94.8%, 384/406) for the household. Conclusion: Symptoms of ALRI reported by caregivers is high in the Kintampo area of Ghana where biomass fuel use is also high. There is the need to initiate interventions that use improved cook stoves and to test the health benefits of such interventions.

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Placental Malaria and the Risk of Malaria in Infants in a High Malaria Transmission Area in Ghana: A Prospective Cohort Study

Cited by 47 publications

References 27 publications

Low Utilization of Insecticide-Treated Bed Net among Pregnant Women in the Middle Belt of Ghana

Low Utilization of Insecticide-Treated Bed Net among Pregnant Women in the Middle Belt of Ghana

In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study

Childhood Respiratory Morbidity and Cooking Practices Among Households in a Predominantly Rural Area of Ghana

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